HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney

Kidney International

Volumn 45, Issue 1, 1994, Pages 48-57

  Ryan, Michael J ^a   Johnson, Gretchen ^a   Kirk, Judy ^a   Fuerstenberg, Sally M ^a   Zager, Richard A ^a,b   Torok Storb, Beverly ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL CULTURE; CELL LINE; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0028010818     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1994.6     Document Type: Article

References (48)

1. ABCOUWER S, ROBINSON PS, GOOCHEE CF, CROW MT: Generation of human embryonic kidney cells with extended in vitro life span through viral oncogene transfection. Bio/Technol 7:939-946, 1989
2. CHANG SE: In vitro transformation of human epithelial cells. Biochim Biophys Acta 823:161-194, 1986
3. NANUS, DM, LYNCH SA, PULIVARTHI HR, ANDERSON SM, JHANWAR SC, ALBINO AP: Transformation of human kidney proximal tubule cells by a src-containing retrovirus. Oncogene 6:2105-2111, 1991
4. GRAHAM FL, SMILEY J, RUSSELL WC, NAIRN R: Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36:59-72, 1977
5. ROBINSON PS, GOOCHEE CF: Kidney-specific enzyme expression by human kidney cell lines generated through oncogene transfection. J Cell Physiol 148:54-59, 1991
6. HOWLEY PM: Role of human papillomaviruses in human cancer. Cancer Res 51:5019s-5022s, 1991
7. VOUSDEN K: Human papillomavirus oncoproteins. Semin Cancer Biol 1:415-424, 1990
8. HAWLEY-NELSON P, VOUSDEN KH, HUBBERT NL, LOWY DR, SCHILLER JT: HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 8:3905-3910, 1989
9. HALBERT CL, DEMERS GW, GALLOWAY DA: The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J Virol 65:473-478, 1991
10. PIRISI L, CREEK KE, DONIGER J, DIPAOLO JA: Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 9:1573-1579, 1988
11. DÜRST M, DZARLIEVA-PETRUSEVSKA RT, BOUKAMP P, FUSENIG NE, GISSMANN L: Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene 1:251-256, 1987
12. PIRISI L, YASUMOTO S, FELLER M, DONIGER J, DIPAOLO JA: Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J Virol 61:1061-1066, 1987
13. PHELPS WC, YEE CL, MÜNGER K, HOWLEY PM: The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. Cell 53:539-547, 1988
14. STOREY A, PIM D, MURRAY A, OSBORN K, BANKS L, CRAWFORD L: Comparison of the in vitro transforming activities of human papillomavirus types. EMBO J 7:1815-1820, 1988
15. MÜNGER K, WERNESS BA, DYSON N, PHELPS WC, HARLOW E, HOWLEY PM: Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J 8:4099-4105, 1989
16. LEVINE A, MOMAND J, FINLAY CA: The p53 tumor suppressor gene. Nature 351:453-456, 1991
17. SCHEFFNER M, WERNESS BA, HUIBREGTSE JM, LEVINE AJ, HOWLEY PM: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136, 1990
18. BLANTON RA, COLTRERA MD, GOWN AM, HALBERT CL, MCDOUGALL JK: Expression of the HPV16 E7 gene generates proliferation in stratified squamous cell cultures which is independent of endogenous p53 levels. Cell Growth Differ 3:791-802, 1992
19. ZAGER RA, SCHIMPF BA, GMUR DJ: Physiological pH effects on posthypoxic proximal tubular injury. Circ Res 72:837-846, 1993
20. MILLER AD, BENDER MA, HARRIS EAS, KALEKO M, GELINAS RE: Design of retrovirus vectors for transfer and expression of the human β-globin gene. J Virol 62:4337-4345, 1988
21. RUTENBURG AM: Histochemical demonstration of alkaline phosphatase using naphthol AS phosphate: Comparison with the substituted naphthol AS phosphates. Annal D Histochimie 11:139-149, 1966
22. RUTENBURG AM, KIM H, FISCHBEIN JW, HANKER JS, WASSERKRUG HL, SELIGMAN AM: Histochemical and ultrastructural demonstration of γ-glutamyl transpeptidase activity. J Histochem Cytochem 17:517-526, 1969
23. BURSTONE MS: Histochemical comparison of napthol AS phosphates for the demonstration of phosphatases. J Natl Cancer Inst 20:601-616, 1958
24. NACHLAS MM, MONIS B, ROSENBLATT D, SELIGMAN AM: Improvement in the histochemical localization of leucine aminopeptidase with a new substrate L-leucyl-4-methoxy-2 naphthylamide. J Biophys Biochem Cytol 7:261-264, 1960
25. MOREL F: Sites of hormone action in the mammalian nephron. Am J Physiol 240:F159-F164, 1981
26. MARX SJ, FEDAK SA, AURBACH GD: Separation and characterization of a hormone-responsive renal plasma membrane reaction. J Biol Chem 24:3913-3918, 1972
27. CHUNG SD, ALAVI N, LIVINGSTON D, HILLER S, TAUB M: Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium. J Cell Biol 95:118-126, 1982
28. BECK JC, SACKTOR B: The sodium electrochemical potential-mediated uphill transport of D-glucose in renal brush border membrane vesicles. J Biol Chem 253:5531-5535, 1978
29. KINNE R, MURER H, KINNE-SAFRAN E, THEES M, SACHS G: Sugar transport by renal plasma membrane vesicles. Characterization of the systems in the brush-border microvilli and basal-lateral plasma membranes. J Membr Biol 21:375-395, 1975
30. INMAN WH, COLOWICK SP: Growth factor stimulation of sugar uptake. Meth Enzymol 146:399-402, 1987
31. MALSTRÖM K, STANGE G, MURER H: Identification of proximal tubular transport functions in the established kidney cell line, OK. Biochim Biophys Acta 902:269-277, 1987
32. MISFELDT DS, SANDERS JM: Transepithelial glucose transport in cell culture. Am J Physiol 240:C92-C95, 1981
33. WILSON PD, ANDERSON RJ, BRECKON RD, NATHRATH W, SCHRIER RW: Retention of differentiated characteristics by cultures of defined rabbit kidney epithelia. J Cell Physiol 130:245-254, 1987
34. ZAGER RA: Combined mannitol and deferoxamine therapy for myohemoglobinuric renal injury and oxidant tubular stress. J Clin Invest 90:711-719, 1992
35. PRICE P, MCMILLAN TJ: Use of the tetrazolium assay in measuring the response of human tumor cells in ionizing radiation. Cancer Res 50:1392-1396, 1990
36. MOSSMAN T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Meth 65:55-63, 1983
37. SLATER TF, SAWYER B, STRAULI UD: Studies on succinate-tetrazolium reductase systems. III. Points of coupling of four different tetrazolium salts. Biochim Biophys Acta 77:383-393, 1963
38. TOUTAIN H, VAUCLIN-JACQUES N, FILLASTRE JP, MOLLIN JP: Biochemical, functional, and morphological characterization of a primary culture of rabbit proximal tubule cells. Exp Cell Res 194:9-18, 1991
39. KEMPSON SA, MCATEER JA, AL-MAHROUQ HA, DOUSA TP, DOUGHERTY GS, EVAN AP: Proximal tubule characteristics of cultured human renal cortex epithelium. J Lab Clin Med 113:285-296, 1989
40. WILSON PD, DILLINGHAM MA, BRECKON R, ANDERSON RJ: Defined human renal tubular epithelia in culture: Growth, characterization, and hormonal response. Am J Physiol 248:F436-F443, 1985
41. ROMERO MF, DOUGLAS JG, ECKERT RL, HOPFER U, JACOBBERGER JW: Development and characterization of rabbit proximal tubular epithelial cell lines. Kidney Int 42:1130-1144, 1992
42. LUNA LG (EDITOR): Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology (3rd ed), New York, McGraw Hill, 1968, p. 171
43. FRANKE WW, WEBER K, OSBORN M, SCHMID E, FREUDENSTEIN C: Antibody to prekeratin: Decoration of tonofilament-like arrays in various cells of epithelial character. Exp Cell Res 116:429-445, 1978
44. SCHLEGEL R, BANKS-SCHLEGEL S, PINKUS GS: Immunohistochemical localization of keratin in normal human tissues. Lab Invest 42:91-96, 1980
45. GIGI O, GEIGER B, ESHHAR Z, MOLL R, SCHMID E, WINTER S, SCHILLER DL, FRANKE WW: Detection of a cytokeratin determinant common to diverse epithelial cells by a broadly based crossed reacting monoclonal antibody. EMBO J 11:1429-1437, 1982
46. LAZARIDES E: Intermediate filaments: A chemically heterogeneous, developmentally regulated class of proteins. Annu Rev Biochem 51:219-250, 1982
47. 1 in epithelial basement membranes. Cell 65:599-610, 1991
48. FRANTZ CN, DUERST RE, RYAN DH, GELSOMINO NL, CONSTINE LS, GREGORY PK: Anti-neuroblastoma monoclonal antibodies which do not bind to bone marrow cells. Prog Clin Biol Res 175:485-499, 1985