1.56 Å structure of mature truncated human fibroblast collagenase

Proteins: Structure, Function, and Bioinformatics

Volumn 19, Issue 2, 1994, Pages 98-109

  Spurlino, John C ^a   Smallwood, Angela M ^a   Carlton, Dennis D ^a   Banks, Tracey M ^a   Vavra, Karen J ^a   Johnson, Jeffrey S ^a   Cook, Ewell R ^a   Falvo, Joseph ^a   Wahl, Robert C ^a   Pulvino, Tricia A ^a   Wendoloski, John J ^a   Smith, Douglas L ^a  

^a EASTMAN KODAK COMPANY   (United States)

Author keywords

crystallography; high resolution; hydroxamate; metalloproteinase; X ray; zinc

Indexed keywords

CALCIUM; COLLAGENASE; COLLAGENASE INHIBITOR; HYDROXAMIC ACID; METALLOPROTEINASE; THERMOLYSIN; ZINC;

ARTICLE; COLLAGEN DEGRADATION; COLLAGEN METABOLISM; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY ANALYSIS; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; COMPUTER GRAPHICS; ENZYMOLOGY; FIBROBLAST; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; COLLAGENASES; COMPUTER GRAPHICS; CRYSTALLOGRAPHY, X-RAY; FIBROBLASTS; HUMAN; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; ZINC;

EID: 0028007891     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.340190203     Document Type: Article

References (28)

1. Matrix metalloproteinases and their inhibitors in connective tissue remodeling
2. The collagenase gene family in humans consists of at least four members
3. Matrix metalloproteinases. A review
4. The collagen substrate specificity of human skin fibroblast collagenase
5. Comparison of human stromelysin and collagenase by cloning and sequence analysis
6. Metal ion stabilization of the conformation of a recombinant 19‐kDa catalytic fragment of human fibroblast collagenase
7. Software for a diffractometer with multi‐wire area detector
8. The use of an imagining proportional counter in macromolecular crystallography
9. Stereochemically restrained refinement of macromolecular structures
10. CHAIN–A crystallographic modeling program J
11. Iodination of a single tyrosine in crystals of α‐chymotrypsin
12. Occurence and role of cis peptide bonds in protein structures
13. Ribbon models of macromolecules
14. 73 active‐site zinc complex in latency and a “cysteine switch” mechanism for activation
15. Structural comparison suggests that thermolysin and related neutral proteases undergo hinge‐bending motion during catalysis
16. The protein data bank: A computer based archival file for macro‐molecular structures
17. Exploring structural homology of proteins
18. Structure of astacin and implications for activation of astacins and zinc‐ligation of collagenases
19. First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases
20. Characterization of zinc‐binding sites in human stromelysin‐l: Stoichiometry of the catalytic domain and the identification of a cysteine ligand in the proenzyme
21. Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis
22. Tertiary templates for proteins
23. Structural basis of the action of thermolysin and related zinc peptidases
24. Binding of N‐carboxymethyl dipeptide inhibitors to thermolysin determined by x‐ray crystallography: A novel class of transition‐state analogues for zinc peptidases