The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds

Toxicology Letters

Volumn 70, Issue 1, 1994, Pages 1-22

  Okey, Allan B ^a   Riddick, David S ^a   Harper, Patricia A ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Ah receptor; Dioxins

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; AROMATIC HYDROCARBON RECEPTOR; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN;

HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; REVIEW;

ANIMAL; BINDING SITES; CELL LINE; CLONING, MOLECULAR; DNA; GENE EXPRESSION REGULATION; HUMAN; HYDROCARBONS, HALOGENATED; PHYLOGENY; RECEPTORS, ARYL HYDROCARBON; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TETRACHLORODIBENZODIOXIN;

ANIMALIA; RODENTIA;

EID: 0028006520     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(94)90139-2     Document Type: Review

References (125)

1. Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
2. Cancer mortality among workers in chemical plant contaminated with dioxin
3. US government orders new look at dioxin
4. More pieces in the dioxin puzzle
5. Dioxin toxicity: new studies prompt debate, regulatory action
6. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.
7. 2,3,7,8-Tetrachlorodibenzo-thorn-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
8. Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)
9. Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action
10. The Ah receptor and the mechanism of dioxin toxicity.
11. The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands
12. Cloning of a factor required for activity of the Ah (dioxin) receptor
13. cDNA cloning and structure of mouse putative Ah receptor
14. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.
15. The steroid and thyroid hormone receptor superfamily
16. Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse.
17. r 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor
18. Association of the Ah receptor with the 90-kDa heat shock protein.
19. Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7
20. Structure and function of the Ah receptor for 2,3,7,8- tetrachlorodibenzo-p-dioxin: species difference in molecular properties of the receptors from mouse and rat hepatic cytosols
21. Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin
22. Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats
23. b−3 alleles
24. 3H]tetrachloro-dibenzo-p-dioxin
25. 3H]tetrachlorodibenzo-p-dioxin
26. Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten.
27. Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor
28. Characterization of multiple forms of the Ah receptor: comparison of species and tissues
29. Ribonuclease inhibits Ah receptor transformation in vitro.
30. Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting.
31. Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.
32. Superinduction of CYP1A1 transcription by cycloheximide. Role of the DNA binding site for the liganded Ah receptor.
33. ATP promotes the appearance of two DNA-binding forms of the Ah receptor
34. Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.
35. Comparison of the nuclear and cytosolic forms of the Ah receptor from Hepa 1c1c7 cells: Charge heterogeneity and ATP binding properties
36. Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment.
37. P450 Genes: Structure, Evolution, and Regulation
38. Molecular genetics of the P-450 superfamily
39. Enzyme induction in the cytochrome P-450 system
40. Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.
41. Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex.
42. Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.
43. Regulation of CYP1A1 expression.
44. 1) gene structure and induction by dioxin
45. The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.
46. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.
47. Classification of members of the Ah gene battery
48. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: A new hypothesis on the role of P-450 in dioxin toxicity
49. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase.
50. The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects
51. 1-450 by 3-meth-ylcholanthrene
52. Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.
53. 6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
54. Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: Structure-activity relationships as Ah receptor agonists and partial antagonists
55. Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
56. 125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes
57. Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
58. The mechanism of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
59. Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor.
60. Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor
61. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: I. Similarities to Staphylococcus aureus Cowan Strain I (SAC) in the in vitro T-dependent antibody response
62. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity: II. B cell activation
63. Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans
64. The aryl hydrocarbon (Ah) receptor
65. Use of artificial intelligence in structure—affinity correlations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor ligands
66. Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.
67. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
68. Production ofahreceptor ligands in rat fecal suspensions containing tryptophan or indole‐3‐carbinol
69. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation
70. Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.
71. Ultraviolet photoproducts of tryptophan can act as dioxin agonists.
72. Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.
73. Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor
74. Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.
75. The stability of dioxin-receptor ligands influences cytochrome P450IA1 expression in human keratinocytes
76. Comparative in vitro transformation of the aromatic hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene
77. Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species
78. Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer
79. The receptor and dioxin toxicity: From rodent to human tissues
80. Ah receptor for 2,3,7,8- tetrachlorodibenzo-p-Dioxin: Ontogeny in chick embryo liver
81. 3H]2,3,7,8-tetrachlorodibenzo-p-dioxin binding to Ah receptor in a rainbow trout hepatoma cell line
82. 125I]iodo-7,8-dibromodibenzo-p-dioxin in cell culture
83. Nondetectable concentrations of human placental ah receptors are associated with potent induction of microsomal benzo6a9pyrene hydroxylase in individuals exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans
84. Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
85. Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines
86. In vitro transformation of the human Ah receptor and its binding to a dioxin response element.
87. Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.
88. Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental Ah receptor—A QSAR analysis
89. 7-Substituted-2,3-dichlorodibenzo-p-dioxins as competitive ligands for the Ah receptor: Quantitative structure-activity relationships (QSARs) and a comparison of human receptor with Ah receptor from rodents
90. In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines*1
91. Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180
92. Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
93. 3H]2,3,7,8- tetrachlorodibenzo-p-dioxin and relationship to the activity of aryl hydrocarbon hydroxylase
94. Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line Hep G2
95. Detection and characterization of Ah receptor in tissue and cells from human tonsils
96. 125I]2-iodo-7,8-dibromodibenzo-p-dioxin
97. Ah receptor for 2,3,7,8- tetrachlorodibenzo-p-dioxin: a population study with human placentas
98. Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin
99. Factors affecting the toxicity of dioxin-like toxicants: a molecular approach to risk assessment of dioxins
100. Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.
101. Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.
102. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.
103. Differential gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Noncoordinate regulation of a TCDD-induced aldehyde dehydrogenase and cytochrome P-450c in the rat.
104. Superinduction of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase by the inhibition of protein synthesis
105. Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase in hepatoma cells
106. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.
107. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.
108. Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.
109. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17β-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression
110. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action
111. Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta
112. 2 in a human keratinocyte cell line involves both transcriptional and post-transcriptional control
113. Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1
114. Receptors of polycyclic aromatic hydrocarbons
115. Induction of 7-ethoxycoumarin O-deethylase activity in cultured human epithelial cells by 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD): Evidence for TCDD receptor
116. Filtration assay for quantitation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) specific binding to whole cells in culture
117. Decrease in cold tolerance of aged rats caused by the enhanced endogenous adenosine activity
118. Induction of aryl hydrocarbon hydroxylase and demonstration of a specific nuclear receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in two human hepatoma cell lines
119. 1-450 expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines
120. 3H]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
121. The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line
122. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
123. Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors
124. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) enhances terminal differentiation of cultured human epidermal cells
125. Characterization of a specific binding protein for 2,3,7,8-tetrachlorodibenzo-p-dioxin in human thymic epithelial cells.