Dipeptidyl carboxypeptidase-1 gene polymorphism paradox in hypertension explained by ‘deletion depletion’

Journal of Hypertension

Volumn 12, Issue 10, 1994, Pages 1199-1200

  Morris, Brian J ^a   Zee, Robert Y L ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME POLYMORPHISM; GENE DELETION; GENE INSERTION; HUMAN; HYPERTENSION; LETTER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0028004278     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: None     Document Type: Letter

References (8)

1. Zee RYL, Lou Y-K, Griffiths LR, Morris BJ: Association of a polymorphism of the angiotensin l-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun 1992, 184:9–15.
2. Morris BJ, Zee RYL, Ying L-H, Griffiths LR: Independent, marked associations of alíeles of the insulin receptor and dipeptidyl carboxypeptidase-1 genes with essential hypertension. Clin Sci 1993, 85:189–195.
3. Schmidt S, van Hooft IMS, Grobbee DE, Ganten D, Ritz E: Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. Hypertens 1993, 11:345–348.
4. Harrap SB, Davidson HR, Connor JM, Soubrier F, Corvol P, Fraser R, et al: The angiotensin l-converting enzyme gene and predisposition to high blood pressure. Hypertension 1993, 21:455–460.
5. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel J-M: Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1992 1:72–75.
6. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin l-converting enzyme gene accounting for half of the variance of serum enzyme levels. J Clin Invest 1990, 86:1343–1346.
7. Cambien F, Poirer O, Lecerf L, Evans A, Cambou J-P, Arveiler D, et al: Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992, 359:641–644.
8. Morris BJ, Zee RYL, Schrader AP: Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest 1994, 94:1085-1089.