Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients

Molecular Brain Research

Volumn 26, Issue 1-2, 1994, Pages 113-122

  Ulloa, Luis ^a   Montejo de Garcini, Esteban ^a   Gómez Ramos, Pilar ^a   Morán, María A ^a   Avila, Jesús ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Cytoskeletal disorder; Proline dependent phosphorylation

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; PROTEIN KINASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; FETUS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMAL; AXONS; BLOTTING, WESTERN; BRAIN; CELL NUCLEUS; COMPARATIVE STUDY; FEMALE; FETUS; HUMAN; MALE; MICROSCOPY, IMMUNOELECTRON; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGE; NEUROFIBRILLARY TANGLES; OLFACTORY BULB; PHOSPHOPROTEINS; PHOSPHORYLATION; PROLINE-DIRECTED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RATS; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; TAU PROTEINS;

EID: 0028003725     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(94)90081-7     Document Type: Article

References (66)

1. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
2. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
3. Evidence that transmitter containing dystrophic neurites precede paired helical filament and Alz50 formation within senile plaques in the amygdala of non-demented elderly and patients with Alzheimer's disease
4. Microtubule-associated protein MAP1B
5. ERKS: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
6. Occurrence of neuropil threads in senile brain and in Alzheimer's disease
7. 396 in Alzheimer's disease recapitulates phosphorylation during development and contributes to reduced microtubule binding
8. An immunocytochemical and biochemical study of the microtubule associated protein tau during postlesion afferent reorganization in the hippocampus of adult rat
9. Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer's type
10. A casein kinase II related activity is involved in phosphorylation of microtubule associated protein MAP1B during neuroblastoma cell differentiation
11. Mitogen activated protein (MAP) kinase transforms Tau protein into an Alzheimer-like state
12. Association of microtubule associated protein MAP1B with growing axons in cultured hippocampal neurons
13. The abnormal phosphorylation of tau protein at ser 202 in Alzheimer disease recapitulates phosphorylation during development
14. P42 MAP kinase phosphorylation sites in microtubule associated protein tau are dephosphorylated by protein phosphatase 2A1: implications for Alzheimer's disease
15. Phosphoprotein phosphatase activities in Alzheimer disease brain
16. Solubilization and fractionation of paired helical filaments
17. Microtubule-associated protein tau: a component of Alzheimer paired helical filaments
18. Abnormal phosphorylation of the microtubule-associate protein tau in Alzheimer cytoskeletal pathology
19. Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease
20. Down regulation at cdc2 upon terminal differentiation of neurons
21. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease
22. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease
23. Characterization of brain microtubule proteins were prepared by selective removal of mitochondrial and synaptosomal components
24. Diagnosis of Alzheimer's disease
25. Alzheimer's disease a cell biological perspective
26. Microtubule-associated protein tau is a major antigenic component of paired helical filaments in Alzheimer's disease
27. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease
28. Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease
29. Dystrophic peptidergic neurites in senile plaques of Alzheimer's disease hippocampus precede formation of paired helical filaments
30. Neuritic pathology and dementia in Alzheimer's disease
31. Dystrophic neurites precede neurofibrillary tangle formation and mark the progression of dementia in Alzheimer's Disease
32. The distribution and phosphorylation of the microtubule associated protein MAP1B in growth cones
33. Patterns of aberrant sprouting in Alzheimer's disease
34. Analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer's disease
35. Progressive deposition of paired helical filaments (PHF) in the brain characterized the evolution of dementia in Alzheimer's disease
36. Collagenous structures present in brain contains epitopes shared by collagen and microtubule associated protein tau
37. Quantitation and characterization of tau factor porcine tissues
38. Cholinesterase histochemistry in the human brain: effect of various fixation and storage conditions
39. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
40. A possible fetal antigen of Mr. 70000 in neurofibrillary tangles
41. Altered levels of microtubule proteins in brains of Alzheimer's disease patients
42. Differences between tau protein of Alzheimer's paired helical filaments case and normal tau revealed by epitope analyses of monoclonal antibodies 423 and 7.51
43. High molecular weight microtubule associated proteins bind to actin lattices (Hirano bodies)
44. The distribution of tangles, plaques and related immunohistochemical marks, in healthy aging and Alzheimer's disease
45. MAP5 a novel brain microtubule associated protein under strong developmental regulation
46. Phosphorylated MAP1B, also MAP5 and MAP1X, is involved in axonal growth and neuronal mitosis
47. Difference in distribution of microtubule associated proteins 5a and 5b during the development of cerebral cortex and corpus callosum cats: dependence on phosphorylation
48. Microtubule associated protein MAP1B molecular structure, localization and phosphorylation dependent expression in developing neurons
49. MAP1A and MAP1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS
50. Microtubule assembly in the absence of added nucleotides
51. The molecular pathology of Alzheimer's disease
52. Measurement of protein using bicinchoninic acid
53. Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule associated protein 5
54. Some morphometric aspects of the brain in senile dementia of the Alzheimer type
55. Observation of the brain of demented old people
56. In situ localization of microtubule associated protein in RNA in the developing and adult rat brain
57. Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells
58. Heterogeneity in the phosphorylation of microtubule associated protein MAP1B during rat brain development
59. Dephosphorylation of distinct sites on microtubule associated protein MAP1B by protein phosphatases 1, 2A and 2B
60. The adult rat olfactory system expresses microtubule associated proteins found in the developing brain
61. Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology
62. Plaques, tangles and dementia: a quantitative study
63. Subunit structure of paired helical filaments in Alzheimer's disease
64. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
65. Neurofibrillary tangles of Alzheimer's disease share antigenic determinants with the axonal microtubule-associated protein tau
66. Proline-directed kinase systems in Alzheimer's disease pathology