Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Nature Genetics

Volumn 7, Issue 4, 1994, Pages 536-540

  Issa, Jean Pierre J ^a   Ottaviano, Yvonne L ^a   Celano, Paul ^a   Hamilton, Stanley R ^a   Davidson, Nancy E ^a   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR;

AGING; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CARCINOMA CELL; CELL DIFFERENTIATION; COLON CANCER; COLON MUCOSA; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; RECEPTOR GENE; TUMOR SUPPRESSOR GENE;

AGING; BASE SEQUENCE; COLON; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; GENE EXPRESSION; HUMANS; METHYLATION; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, ESTROGEN;

EID: 0028001087     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng0894-536     Document Type: Article

References (43)

1. Bird, A.P. CpG-rich islands and the function of DNA methylation. Nature321, 209-213 (1986).
2. Migeon, B.R. Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa. Genet. Res. 56, 91-98 (1990).
3. Singer-Sam, J. & Riggs, A.D. X chromosome inactivation and DNA methylation. EXS 64, 358-384 (1993).
4. Ferguson-Smith, A.C., Sasaki, H., Cattanach, B.M. & Surani, M.A. Parental-origin-specific epigenetic modification of the mouse H19 gene.Nature 362, 751-755 (1993).
5. Bartolomei, M.S., Webber, A.L., Brunkow, M.E. & Tilghman, S.M. Epigenetic mechanisms underlying the imprinting of the mouse H19gene. Genes Devel. 7, 1663-1673 (1993).
6. Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362-365 (1993).
7. Hayashizaki, Y. et al. Identification of an imprinted U2af binding protein related sequence on mouse chromosome 11 using the RLGS method.Nature Genet. 6, 33-40 (1994).
8. Stoger, R. et al. Maternal-specific methylation of the imprinted mouseIgf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 73, 61-71 (1993).
9. de Bustros, A. et al. The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia. Proc. natn. Acad. Sci. U.S.A. 85, 5693-5697 (1988).
10. Jones, P.A. et al. De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc. natn. Acad. Sci. U.S.A. 87, 6117-6121 (1990).
11. Makos, M. et al. Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer. Proc. natn. Acad. Sci. U.S.A. 89, 1929-1933 (1992).
12. Sakai, T. et al. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am. J. hum. Genet. 48, 880-888 (1991).
13. Oberlé, I. et al. Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science 253, 1097-1102 (1991).
14. Hansen, R.S., Gartler, S.M., Scott, C.R., Chen, S.-H. & Laird, D.C. Methylation analysis of CGG sites in the CpG island of the human FMR1 gene. Hum. molec. Genet. 1, 571-578 (1992).
15. Ottaviano, Y.L., Issa, J.-P.J., Farl, F.F., Smith, H.S., Baylim, S.B. & Davidson, N.E. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.Cancer Res. 54, 2552-2555 (1994).
16. Greene, G.L. et al. Sequence and expression of human estrogen receptor complementary DNA. Science 231, 1150-1154 (1986).
17. Green, S. et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320, 134-139 (1986).
18. Piva, R., Gambari, R., Zorzato, F., Kumar, L. & del Senno, L. Analysis of upstream sequences of the human estrogen receptor gene. Biochem. Biophys. res. Commun. 183, 996-1002 (1992).
19. Colby, W.W., Chen, E.Y., Smith, D.H. & Levinson, A.D. Identification and nucleotide sequence of a human locus homologous to the v-myconcogene of avian myelocytomatosis virus MC29. Nature 301, 722-725 (1983).
20. Neugut, A.I., Jacobson, J.S. & DeVivo, I. Epidemiology of colorectal adenomatous polyps. Cancer Epidemiol. Biomarkers & Prevention 2, 159-176 (1993).
21. Meggough, F., Lointier, P. & Saez, S. Sex steroid and 1, 25-dihydroxyvitamin D3 receptors in human colorectal adenocarcinoma and normal mucosa. Cancer Res. 51, 1227-1233 (1991).
22. Dawson, P.M. et al. Oestrogen receptors in colorectal carcinoma. J. clin. Pathol. 43, 149-151 (1990).
23. Thomas, M.L., Xu, X., Norfleet, A.M. & Watson, C.S. The presence of functional estrogen receptors in Intestinal epithelial cells. Endocrinology132, 426-430 (1993).
24. Corradino, R.A., Smith, C.A., Krook, L.P. & Fullmer, C.S. Tissue-specific regulation of shell gland calbindin D28K biosynthesis byestradiol in precociously matured, vitamin D-depleted chicks. Endocrinology 132, 193-198 (1993).
25. Arjandi, B.H., Salih, M.A., Herbert, D.C., Sims, S.H. & Kalu, D.N. Evidence for estrogen receptor-linked calcium transport in the intestine. Bone & Mineral 21, 63-74 (1993).
26. Brommage, R., Binacua, C. & Carrie, A.L. Ovulation-associated increase in intestinal calcium absorption during the rat estrous cycle is blunted by ovariectomy. Biol. Reprod. 49, 544-548 (1993).
27. Watts, C.K.W., Parker, M.G. & King, R.J.B. Stable transfection of the oestrogen receptor gene into a human osteosarcoma cell line. J. steroid Biochem. 34, 483-490 (1989).
28. Maminta, M.L., Molteni, A. & Rosen, S.T. Stable expression of the human estrogen receptor in HeLa cells by infection: effect of estrogen on cell proliferation and c-myc expression. Molec. cell. Endocrinol. 78, 61-69 (1991).
29. Ma, Z.Q. et al. Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proc. natn. Acad. Sci. U.S.A.90, 3740-3744 (1993).
30. Garcia, M., Derocq, D., Freiss, G. & Rochefort, H. Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proc. natn. Acad. Sci. U.S.A. 89, 11538-11542 (1992).
31. Zajchowski, D.A., Sager, R. & Webster, L. Estrogen inhibits the growth of estrogen receptor-negative, but not estrogen receptor-positive, human mammary epithelial cells expressing a recombinant estrogen receptor.Cancer Res. 53, 5004-5011 (1993).
32. Jiang, S.-Y. & Jordan, V.C. Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J. natn. Cancer Inst. 84, 580-591 (1992).
33. Holliday, R. The inheritance of epigenetic defects. Science 238, 163-70 (1987).
34. Uehara, Y., Ono, T., Kurishita, A., Kokuryu, H. & Okada, S. Age-dependent and tissue-specific changes of DNA methylation within and around the c-fos gene in mice. Oncogene 4, 1023-1028 (1989).
35. Ghazi, H., Gonzales, F.A. & Jones, P.A. Methylation of CpG-island-containing genes in human sperm, fetal and adult tissues. Gene 114, 203-210 (1992).
36. Atillasoy, E. & Holt, P.H. Gastrointestinal proliferation and aging. J. Gerontol. 48, B43-B49 (1993).
37. Antequera, F., Boyes, J. & Bird, A. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62, 503-514 (1990).
38. Tata, J.R., Baker, B.S., Machuca, I., Rabelo, E.M.L. & Yamauchi, K. Autoinduction of nuclear receptor genes and its significance. J. steroid Biochem. & molec. Biol. 46, 105-119 (1993).
39. Sapolsky, R.M., Vogelman, J.H., Orentreich, N. & Altmann, J. Senescent decline in serum dehydroepiandrosterone sulfate concentrations in a population of wild baboons. J. Gerontol. 48, 196-200 (1993).
40. Furner, S.E., Davis, F.G., Nelson, R.L. & Haenszel, W. A sase-control study of large bowel cancer and hormone exposure in women. Cancer Res. 49, 4936-4940 (1989).
41. Chute, C.G. et al. A prospective study of reproductive history and exogenous estrogens on the risk of colorectal cancer in women.Epidemiol. 2, 201-207 (1991).
42. Gerhardswon de Verdier, M. & London, S. Reproductive factors, exogenous female hormones, and colorectal cancer by subsite. Canc. Caus. Cont. 3, 355-360 (1992).
43. Weigel, R.J. & deConinck, E.C. Transcriptlonal control of estrogen receptor in estrogen receptor-negative breast carcinoma. Cancer Res. 53, 3472-3474 (1993).