How to diagnose cobalamin deficiency

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 54, Issue S219, 1994, Pages 61-76

  Nexø, Ebba ^a   Hansen, Mads ^b   Rasmussen, Karsten ^a   Lindgren, Anders ^c   Gräsbeck, Ralph ^d  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

Atrophic gastritis; Homocysteine; Methylmalonate; Pernicious anemia; Plasma; Transcobalamin Cobalamin

Indexed keywords

COBALAMIN; HOMOCYSTEINE; METHYLMALONIC ACID; CYANOCOBALAMIN; GASTRIN; PEPSINOGEN;

ANEMIA; ATROPHIC GASTRITIS; CONFERENCE PAPER; HUMAN; NEUROPSYCHIATRY; PERNICIOUS ANEMIA; PRIORITY JOURNAL; VITAMIN DEFICIENCY; BLOOD; CYANOCOBALAMIN DEFICIENCY; HISTORY; HISTORY OF MEDICINE; METABOLISM; REVIEW; SCHILLING TEST;

GASTRINS; HISTORY OF MEDICINE, 19TH CENT.; HISTORY OF MEDICINE, 20TH CENT.; HOMOCYSTEINE; HUMAN; METHYLMALONIC ACID; PEPSINOGENS; SCHILLING TEST; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 0028000118     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365519409088580     Document Type: Article

References (58)

1. Soluble and membrane-bound vitamin B12 transport proteins
2. The neurology of cobalamin - review article
3. The conquest of pernicious anemia
4. Clinical spectrum and diagnosis of cobalamin deficiency
5. Neurologic aspects of cobalamin deficiency
6. Neuropsychiatric consequences of cobalamin deficiency
7. The neuropsychiatry of megaloblastic anemia
8. What are the psychiatric manifestations of vitamin B12 deficiency?
9. Prevalence of cobalamin deficiency in the Framingham elderly population
10. Low serum cobalamin levels in a population study of 70- and 75-year-old subjects. Gastrointestinal causes and hematological effects
11. Vitamin B-12 abnormalities in HIV-infected patients
12. Pernicious anaemia as a cause of infertility
13. Guidelines on the investigation and diagnosis of cobalamin and folate deficiences
14. Measurement of serum cobalamin
15. Cobalamin Assays
16. Cobalamin analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin
17. 12 using measurement of serum concentration
18. Cobalamin analogues in plasma. An in vitro phenomenon?
19. Construction and use of a RIA-gram
20. Homogeneous Enzyme-Linked assay for vitamin B12
21. Nonisotopic binding assay for measuring vitamin B12 and folate in serum
22. Variation with age of reference values for P-Cobalamin
23. Cobalamin-binding capacity of haptocorrin and transcobalamin: Age-correlated reference intervals and values from patients
24. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin
25. Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people
26. Levels of iron, vitamin B12 and folic acid and their binding proteins during pregnancy
27. Inherited disorders of vitamin B12 utilization
28. Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B12 (cobalamin) absorption in patients with AIDS
29. New assay for the rapid determination of plasma holotranscobalamin II levels: Preliminary evaluation in cancer patients
30. Correlations between holotranscobalamin II, holo-haptocorrin, and total B12 in serum samples from healthy subjects and patients
31. Measurement of TC-cobalamin, a marker of cobalamin deficiency.[Abstract]
32. Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry
33. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method
34. Methylmalonic acid concentrations in serum of normal subjects: Biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin
35. The usefulness of determination of methylmalomic acid in serum or urine for clinical evaluation of cobalamin deficiency is not invalidated by heterozygotes for methylmalonic-acidaemia
36. Concentrations of methylmalonic acid in serum and urine are not increased in diabetes mellitus [Abstract]
37. Methylmalonic acid concentration in serum not affected in hepatic disease
38. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid
39. Methylmalonic acid in renal insufficiency. Evidence of accumulation and implications for diagnosis of cobalamin deficiency
40. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamine and folate deficiencies
41. Diagnosis of cobalamin deficiency II: Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations
42. Studies on methylmalonic acid in humans. JX Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid
43. Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations
44. Total homocysteine in plasma or serum: methods and clinical applications
45. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum
46. Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry
47. Elevation of serum cystathionine levels in patiens with cobalamin and folate deficiency
48. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status
49. Decreased serum homocysteine in pregnancy
50. Inhibitory effect of eggs on vitamin B)2 absorption: Description of a simple ovalbumin Co-vitamin B12 absorption test
51. Dual isotope Schilling test for measuring absorption of food-bound and free vitamin B12 simultaneously
52. Serum pepsinogens I and II and gastric acid output, effect of gastritis
53. The ratio of pepsinogen A to pepsinogen C: A sensitive test for atrophic gastritis
54. Gastric morphology, function and immunology in first-degree relatives of probands with pernicious anaemia and controls