In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

Biochemical Pharmacology

Volumn 48, Issue 10, 1994, Pages 1989-1992

  Sakata, Atsushi ^a   Tamai, Ikumi ^a   Kawazu, Kouichi ^a   Deguchi, Yoshiharu ^a   Ohnishi, Toshimasa ^a   Saheki, Akira ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

active transport; blood brain barrier; cyclosporin A; ischemia; multidrug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; GLYCOPROTEIN P; QUINIDINE; RADIOISOTOPE; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DEPLETION; DRUG TRANSPORT; HIPPOCAMPUS; MALE; MICRODIALYSIS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; VERTEBRAL ARTERY STENOSIS;

ADENOSINE TRIPHOSPHATE; ANIMAL; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CYCLOSPORINE; MALE; P-GLYCOPROTEIN; RATS; RATS, INBRED F344; SUPPORT, NON-U.S. GOV'T;

EID: 0027998226     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90601-7     Document Type: Article

References (27)

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5. In vitro and in vivo assessment of the blood-brain barrier permeability of cyclosporin A and FK-506
6. Influence of blood components on the tissue uptake indices of cyclosporin in rat
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