Single-dose ciprofloxacin for the treatment of uncomplicated gonorrhea: A worldwide summary

Sexually Transmitted Diseases

Volumn 21, Issue 6, 1994, Pages 345-352

  Echols, Roger M ^a,b,c   Heyd, Allen ^a,b,c   O’keeffe, Brian J ^a,b,c   Schacht, Peter ^a,b,c  

^a BAYER CORPORATION   (United States)

^b Bayer plc UK   (United Kingdom)

^c BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMPICILLIN; CEFTRIAXONE; CIPROFLOXACIN; PENICILLIN G; PROBENECID; SPECTINOMYCIN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GONORRHEA; HUMAN; MAJOR CLINICAL STUDY; MALE; NEISSERIA GONORRHOEAE; ORAL DRUG ADMINISTRATION; PHARYNGITIS; RANDOMIZED CONTROLLED TRIAL; URETHRITIS; UTERINE CERVICITIS;

ANTIBIOTICS--ADMINISTRACTION AND DOSAGE; CLINICAL RESEARCH; CLINICAL TRIALS; DEVELOPED COUNTRIES; DEVELOPING COUNTRIES; DISEASES; DRUGS; GONORRHEA; HEALTH; INFECTIONS; LITERATURE REVIEW; PUBLIC HEALTH; REPRODUCTIVE TRACT INFECTIONS; RESEARCH REPORT; SAFETY; SEXUALLY TRANSMITTED DISEASES; TREATMENT;

ADULT; CIPROFLOXACIN; CLINICAL TRIALS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FEMALE UROGENITAL DISEASES; GONORRHEA; HUMANS; MALE; MALE UROGENITAL DISEASES; PENICILLIN RESISTANCE; PHARYNGEAL DISEASES; RECTAL DISEASES; TETRACYCLINE RESISTANCE; TREATMENT OUTCOME;

EID: 0027997535     PISSN: 01485717     EISSN: 15374521     Source Type: Journal    
DOI: 10.1097/00007435-199411000-00009     Document Type: Article

References (42)

1. Schwarcz SK, Zenilman JM, Schnell D, et al. National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. JAMA 1990; 264: 1413-1417.
2. Lind I. Epidemiology of antibiotic resistant Neisseria gonorrhoeae in industrialized and developing countries. Scand J Infect Dis 1990; 69: 77-82.
3. Centers for Disease Control. Plasmid-mediated antimicrobial resistance in Neisseria gonorrhoeae-United States, 1988-1989. MMWR 1990; 39: 284-293.
4. Otubu JA, Imade GE, Sagay AS, Towobola OA. Resistance of recent Neisseria gonorrhoeae isolates in Nigeria and outcome of single-dose treatment with ciprofloxacin. Infect 1992; 20: 339-341.
5. Kam KM, Lai CF, Egglestone S, Chan CB. Patterns of antibiotic susceptibility of gonococci isolated in Hong Kong 1987-1990. Sex Transm Dis 1992; 19: 284-287.
6. Korting HC, Abeck D, Zaba R. Increase of the relative frequency of penicillinase-producing Neisseria gonorrhoeae strains to more than five per cent in Munich. Int J Med Microbiol 1990; 272: 313-317.
7. Centers for Disease Control. Sentinel surveillance for antimicrobial resistance in Neisseria gonorrhoeae-United States, 1988-1991. MMWR 1993; 42: 29-39.
8. Centers for Disease Control. 1993 Sexually transmitted diseases treatment guidelines. MMWR 1993; 42: 1-102.
9. Moran JS, Zenilman JM. Therapy for gonococcal infections: options in 1989. Rev Infect Dis 1990; 12 (suppl 6): S633-S644.
10. Barry AL, Jones RN, Thornsberry C, Ayers LW, Gerlach EH, Sommers HM. Antibacterial activities of ciprofloxacin, norfloxacin, oxolinic acid, cinoxacin, and nalidixic acid. Antimi-crob Agents Chemother 1984; 25: 633-637.
11. Peeters M, Van Dyck E, Piot P. In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae. Antimicrob Agents Chemother 1984; 26: 608-609.
12. Wise R, Andrews JM, Edwards LJ. In vitro activity of Bay o 9867, a new quinolone derivative, compared with those of other antimicrobial agents. Antimicrob Agents Chemother 1983; 23: 559-564.
13. Aznar J, Caballero MC, Lozano MC, et al. Activities of new quinolone derivatives against genital pathogens. Antimicrob Agents Chemother 1985; 27: 76-78.
14. Hart CA, How SJ, Hobson D. Activity of ciprofloxacin against genital tract pathogens. Br J Vener Dis 1984; 60: 316-318.
15. Lozano MC, Palomares JC, Prados R, Perea EJ. In vitro activity of 14 antimicrobial agents against Neisseria gonorrhoeae from Spain [letter]. Genitourin Med 1987; 63: 215-216.
16. Lyon MD, Smith KR, Saag MS, Cobbs CG. Brief Report: in vitro activity of ciprofloxacin against Neisseria gonorrhoeae. Am J Med 1987; 82 (suppl 4A): 40-41.
17. Kaukoranta-Tolvanen S-SE, Renkonen O-VJ. In vitro susceptibility of Neisseria gonorrhoeae to RO 23-6240 and ciprofloxacin. Eur J Clin Microbiol 1987; 6: 315-317.
18. Easmon CSF, Woodford N, Ison CA. The activity of the 4 quinolone RO 236240 and the cephalosporins RO 158074 and RO 195247 against penicillin sensitive and resistant gonococci. J Antimicrob Chemother 1987; 19: 161-165.
19. Handsfield HH, McCutchan JA, Corey L, Ronald AR. Evaluation of new anti-infective drugs for the treatment of uncomplicated gonorrhea in adults and adolescents. Clin Infect Dis 1992; 15 (suppl 1): S123-S130.
20. Hook EW III, Jones RB, Martin DH, et al. Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women. Antimicrob Agents Chemother 1993; 37: 1670-1673.
21. Roddy RE, Handsfield HH, Hook EW. Comparative trial of single-dose ciprofloxacin and ampicillin plus probenecid for treatment of gonococcal urethritis in men. Antimicrob Agents Chemother 1986; 30: 267-269.
22. Bryan JP, Hira SK, Brady W, et al. Oral ciprofloxacin versus ceftriaxone for the treatment of urethritis from resistant Neisseria gonorrhoeae in Zambia. Antimicrob Agents Chemother 1990; 34: 819-822.
23. Scott GR, McMillan A, Young H. Ciprofloxacin versus ampicillin and probenecid in the treatment of uncomplicated gonorrhea in men. J Antimicrob Chemother 1987; 20: 117-121.
24. Belli I, Castro JM, Casco YR. Ciprofloxacin in the treatment of uncomplicated gonococcal urethritis. In: Arango JC, Bernardo FC, Belli I, et al., eds. Ciprofloxacin: A New Era in Antibiotics. Stuttgart, Germany: Schwer Verlag GmbH; 1988: 75-77.
25. Lassus A, Karppinen L, Ingervo L, et al. Ciprofloxacin versus amoxicillin and probenecid in the treatment of uncomplicated gonorrhea. Scand J Infect Dis 1989; 60 (suppl): 58-61.
26. Traisupa A. The role of ciprofloxacin in sexually transmitted diseases. Int J Clin Pract 1990; 6 (suppl 1): 47-50.
27. Balachandran T, Roberts AP, Evans BA, Azadian BS. Single dose therapy of anogenital and pharyngeal gonorrhea with ciprofloxacin. Int J STD & AIDS 1992; 3: 49-51.
28. Loo PS, Ridgway GL, Oriel JD. Single dose ciprofloxacin for treating gonococcal infections in men. Genitourin Med 1985; 61: 302-305.
29. Shahmanesh M, Skulka SR, Phillips I, Westwood A, Thin RN. Ciprofloxacin for treating urethral gonorrhea in men. Genitourin Med 1986; 62: 86-87.
30. Belli L, Castro JM, Casco R. Ciprofloxacin in the treatment of non-complicated gonococcal urethritis. Recent Advances in Chemotherapy. In: Proceedings of the 14th International Congress of Chemotherapy; Kyoto, Japan; 1985: 1687-1688.
31. da L’Exposto F, Duncan MO, Dangor Y, Fehler HG, Leibowitz L, Ballard RC. In vitro activity and clinical efficacy of ciprofloxacin for the treatment of gonorrhea and associated infections. Presented at the 15th International Congress of Chemotherapy; July 19-24, 1987; Istanbul, Turkey. Abstract 1201.
32. Perea EJ, Prados R, de Miguel C, Aznar J. Single-dose ciprofloxacin treatment of gonococcal urethritis. Proc Exc Med 1985; Ser 34: 338-341.
33. Avonts D, Fransen L, Vielfont J, Stevens A, Hendrickx K, Piot P. Treating uncomplicated gonococcal infection with 250 mg or 100 mg ciprofloxacin in a single oral dose. Genitourin Med 1988; 64: 134-137.
34. Stolz E, Tegelberg-Stassen MJAM, vd Hoek JCS, Wagenvoort JHT. Clinical efficacy of ciprofloxacin in gonorrhea. Proc Exc Med 1985; Ser 34: 336-337.
35. Szarmach H, Weuta H, Podziewski J, Skarzynski J, Wronski A. Ciprofloxacin in acute male gonorrhea. Arzneim Forsch Drug Res 1986; 36: 1840-1842.
36. Aznar J, Prados F, Rodriguez-Pichardo A, et al. Comparative clinical efficacy of two different single-dose ciprofloxacin treatments for uncomplicated gonorrhea. Sex Transm Dis 1986; 13: 169-171.
37. Martin DH, Mroczkowski TF, Dalu ZA, et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. N Engl J Med 1992; 327: 921-925.
38. Handsfield HH, McCormack WM, Hook EW III, et al. Acomparison of single-dose cefixime with ceftriaxone as treatment for uncomplicated gonorrhea. N Engl J Med 1991; 325: 1337-1341.
39. Drug Topics Red Book 1993. Oradell, NJ: Medical Economics, 1993.
40. Jephcott AE, Turner A. Ciprofloxacin resistance in gonococci. Lancet 1990; 335: 165.
41. Yeung KH, Dillon JR. Norfloxacin resistant Neisseria gonorrhoeae in North America. Lancet 1990; 336: 759.
42. Clendennen TE, Echeverria P, Saengeui S, Kees ES, Boslego JW, Wignall FS. Antimicrobial susceptibility survey of Neisseria gonorrhoeae in Thailand. Antimicrob Ag Chemother 1992; 36: 1682-1687.