Involuntary stepping after chronic spinal cord injury: Evidence for a central rhythm generator for locomotion in man

Brain

Volumn 117, Issue 5, 1994, Pages 1143-1159

  Calancie, Blair ^a,b   Needham shropshire, Belinda ^a,b   Jacobs, Patrick ^a,b   Willer, Keith ^a,b   Zych, Gregory ^c   Green, Barth A ^a,b  

^a UNIVERSITY OF MIAMI   (United States)

^b Department of Neurological Surgery ^*  (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Central rhythm generator; Locomotion; Spinal cord injury

Indexed keywords

ADULT; ARTICLE; CASE REPORT; CERVICAL SPINAL CORD; ELECTROMYOGRAM; FACILITATION; HIP; HUMAN; INVOLUNTARY MOVEMENT; LEG MUSCLE; LOCOMOTION; MALE; PRIORITY JOURNAL; SENSORY STIMULATION; SPINAL CORD INJURY; SUPINE POSITION;

ADULT; BRAIN; ELECTROMYOGRAPHY; EVOKED POTENTIALS; HUMANS; LEG; LOCOMOTION; MALE; MOTOR CORTEX; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCLE, SMOOTH; SPINAL CORD INJURIES;

EID: 0027994873     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/117.5.1143     Document Type: Article

References (57)

1. Amemiya M, Yamaguchi T. Fictive locomotion of the forelimb evoked by stimulation of the mesencephalic locomotor region in the decerebrate cat. Neurosci Lett 1984; 50: 91-6
2. Barbeau H, Rossignol S. Recovery of locomotion after chronic spinalization in the adult cat. Brain Res 1987; 412: 84-95
3. Barbeau H, Chau C, Rossignol S. Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res Bull 1993; 30: 387-93
4. Barker AT, Jalinous R, Freston IL. Non-invasive magnetic stimulation of human motor cortex [letter]. Lancet 1985; 1: 1106-7
5. Baxendale RH, Ferrell WR. The effect of knee joint afferent discharge on transmission in flexion reflex pathways in decerebrate cats. J Physiol (Lond) 1981; 315: 231-42
6. Brown MC, Engberg I, Matthews PBC. The relative sensitivity to vibration of muscle receptors of the cat. J Physiol (Lond) 1967; 192: 773-800
7. Bussel B, Roby-Brami A, Azouvi P, Biraben A, Yakovleff A, Held JP. Myoclonus in a patient with spinal cord transection. Possible involvement of the spinal stepping generator. Brain 1988; 111: 123-515
8. Bussel B, Roby-Brami A, Yakovleff A, Bennis N. Late flexion reflex in paraplegic patients. Evidence for a spinal stepping generator. [Review], Brain Res Bull 1989; 22: 53-6
9. Calancie B, Nordin M, Wallin U, Hagbarth K-E. Motor-unit responses in human wrist flexor and extensor muscles to transcranial cortical stimuli. J Neurophysiol 1987; 58: 1168-85
10. Capaday C, Stein RB. Amplitude modulation of the soleus H-reflex in the human during walking and standing. J Neurosci 1986; 6: 1308-13
11. Chandler SH, Baker LL, Goldberg LJ. Characterization of synaptic potentials in hindlimb extensor motoneurons during L-DOPA- induced fictive locomotion in acute and chronic spinal cats. Brain Res 1984; 303: 91-100
12. Conway BA, Hultbom H, Kiehn O. Proprioceptive input resets central locomotor rhythm in the spinal cat. Exp Brain Res 1987; 68: 643-56
13. de Guzman CP, Roy RR, Hodgson JA, Edgerton VR. Coordination of motor pools controlling the ankle musculature in adult spinal cats during treadmill walking. Brain Res 1991; 555: 202-14
14. Dietz V, Quintem J, Berger W. Corrective reactions to stumbling in man: functional significance of spinal and transcortical reflexes. Neurosci Lett 1984; 44: 131-5
15. Dietz V, Quintem J, Sillem M. Stumbling reactions in man: significance of proprioceptive and pre-programmed mechanisms. J Physiol (Lond) 1987; 386: 149-63
16. Dobkin BH, Edgerton VR, Fowler E. Sensory input during treadmill training alters rhythmic locomotor EMG output in subjects with complete spinal cord injury [abstract]. Soc Neurosci Abstr 1992; 18: 1403
17. Duysens J, Tax AAM, Trippel M, Dietz V. Phase-dependent reversal of refiexly induced movements during human gait. Exp Brain Res 1992; 90: 404-14
18. Duysens J, Tax AAM, Trippel M, Dietz V. Increased amplitude of cutaneous reflexes during human running as compared to standing. Brain Res 1993; 613: 230-8
19. Eidelberg E, Story JL, Meyer BL, Nystel J. Stepping by chronic spinal cats. Exp Brain Res 1980; 40: 241-6
20. Eidelberg E, Walden JG, Nguyen LH. Locomotor control in macaque monkeys. Brain 1981; 104: 647-63
21. Finch L, Barbeau H, Arsenault B. Influence of body weight support on normal human gait: development of a gait retraining strategy. Phys Ther 1991; 71: 842-55
22. Fleshman JW, Lev-Tov A, Burke RE. Peripheral and central control of flexor digitorum longus and flexor hallucis longus motoneurons: the synaptic basis of functional diversity. Exp Brain Res 1984; 54: 133-19
23. Floeter MK, Sholomenko GN, Gossard J-P, Burke RE. Disynaptic excitation from the medial longitudinal fasciculus to lumbosacral motoneurons: modulation by repetitive activation, descending pathways, and locomotion. Exp Brain Res 1993; 92: 407-19
24. Forssberg H. A developmental model of human locomotion. In: Grillner S, Stein PSG, Stuart DG, Forssberg H, Herman RM, editors. Neurobiology of vertebrate locomotion. Wenner-Gren Center International Symposium Series, Vol. 45. Basingstoke: Macmillan, 1986: 485-504
25. Forssberg H, Grillner S. The locomotion of the acute spinal cat injected with clonidine i.v. Brain Res 1973; 50: 184-6
26. Fung J, Stewart JE, Barbeau H. The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects. J Neurol Sci 1990; 100: 85-93
27. Garcin R, Rondot P, Guiot G. Rhythmic myoclonus of the right arm as the presenting symptom of a cervical cord tumour. Brain 1968; 91: 75-84
28. Gossard J-P, Cabelguen J-M, Rossignol S. Phase-dependent modulation of primary afferent depolarization in single cutaneous primary afferents evoked by peripheral stimulation. Brain Res 1990; 537: 14-23
29. Graham Brown T. The intrinsic factors in the act of progression in the mammal. Proc R Soc Lond [Biol] 1911; 84: 308-19
30. Grillner S. Control of locomotion in bipeds, tetrapods, and fish. In: Brookhart JM, Mountcastle VB, Brooks VB, editors. Handbook of physiology. Sect. 1, Vol. 2, Pt. 2. Bethesda (MD): American Physiological Society, 1981: 1179-236
31. Grillner S, Zangger P. On the central generation of locomotion in the low spinal cat. Exp Brain Res 1979; 34: 241-61
32. Grillner S, Stein PSG, Stuart DG, Forssberg H, Herman RM, editors. Neurobiology of vertebrate locomotion, Wenner-Gren Center International Symposium Series, Vol. 45. Basingstoke: Macmillan, 1986
33. Halliday AM. The electrophysiological study of myoclonus in man. Brain 1967; 90: 241-84
34. Hultbom H, Petersen N, Brownstone R, Nielsen J. Evidence of Active spinal locomotion in the marmoset (Callithrix Jacchus) [abstract]. Soc Neurosci Abstr 1993; 19: 539
35. Inman VT, Ralston HJ, Todd F. Human walking. Baltimore (MD): Williams and Wilkins, 1981
36. Kuhn RA. Functional capacity of the isolated human spinal cord. Brain 1950; 73: 1-51
37. LaBella LA, Niechaj A, Rossignol S. Low-threshold, short-latency cutaneous reflexes during Active locomotion in the ‘semi-chronic’ spinal cat. Exp Brain Res 1992; 91: 236-48
38. Loubser PG, Narayan RK, Sandin KJ, Donovan WH, Russell KD. Continuous infusion of intrathecal baclofen: long-term effects on spasticity in spinal cord injury. Paraplegia 1991; 29: 48-64
39. Lovely RG, Gregor RJ, Roy RR, Edgerton VR. Weight-bearing hindlimb stepping in treadmill-exercised adult spinal cats. Brain Res 1990; 514: 206-18
40. Miller S, Van Der Burg J, Van Der Meche FGA. Coordination of movements of the hindlimbs and forelimbs in different forms of locomotion in normal and decerebrate cats. Brain Res 1975; 91: 217-37
41. Mills KR, Murray NMF. Corticospinal tract conduction time in multiple sclerosis. Ann Neurol 1985; 18: 601-5
42. Pearson KG, Collins DF. Reversal of the influence of group lb afferents from plantaris on activity in medial gastrocnemius muscle during locomotor activity. J Neurophysiol 1993; 70; 1009-17
43. Pearson KG, Rossignol S. Fictive motor patterns in chronic spinal cats. J Neurophysiol 1991; 66: 1874-87
44. Pearson KG, Ramirez JM, Jiang W. Entrainment of the locomotor rhythm by group lb afferents from ankle extensor muscles in spinal cats. Exp Brain Res 1992; 90: 557-66
45. Rack PMH, Ross HF, Thilmann AF. The ankle stretch reflexes in normal and spastic subjects. The response to sinusoidal movement. Brain 1984; 107: 637-54
46. Roby-Brami A, Bussei B. Long-latency spinal reflex in man after flexor reflex afferent stimulation. Brain 1987; 110: 707-25
47. Rossi A, Mazzocchio R, Scarpini C. Clonus in man: a rhythmic oscillation maintained by a reflex mechanism. Electroencephalogr Clin Neurophysiol 1990; 75: 56-63
48. Rossignol S, Gauthier L. An analysis of mechanisms controlling the reversal of crossed spinal reflexes. Brain Res 1980; 182: 31-45
49. Schmidt BJ, Meyers DER, Fleshman JW, Tokuriki M, Burke RE. Phasic modulation of short latency cutaneous excitation in flexor digitorum longus motoneurons during Active locomotion. Exp Brain Res 1988; 71: 568-78
50. Shefchyk SJ, Jordan LM. Excitatory and inhibitory postsynaptic potentials in a-motoneurons produced during Active locomotion by stimulation of the mesencephalic locomotor region. J Neurophysiol 1985a; 53: 1345-55
51. Shefchyk SJ, Jordan LM. Motoneuron input-resistance changes during fictive locomotion produced by stimulation of the mesencephalic locomotor region. J Neurophysiol 1985b; 54: 1101-8
52. Shefchyk SJ, Stein RB, Jordan LM. Synaptic transmission from muscle afferents during fictive locomotion in the mesencephalic- cat. J Neurophysiol 1984; 51: 986-97
53. Shik ML, Orlovskii GN, Severin FV. Locomotion of the mesencephalic cat elicited by stimulation of the pyramids. Biophysics 1968; 13: 143-52
54. Silfverskibld BR Rhythmic myoclonias including spinal myoclonus. Adv Neurol 1986; 43: 275-85
55. Stewart JE, Barbeau H, Gauthier S. Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients. Can J Neurol Sci 1991; 18: 321-32
56. Wainberg M, Barbeau H, Gauthier S. The effects of cyproheptadine on locomotion and on spasticity in patients with spinal cord injuries. J Neurol Neurosurg Psychiatry 1990; 53: 754-63
57. Yamaguchi T. Muscle activity during forelimb stepping in decerebrate cats. Jpn J Physiol 1992; 42: 489-99