Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats

Stroke

Volumn 25, Issue 8, 1994, Pages 1666-1673

  Blot, S ^a,b   Arnal, J F ^b   Xu, Y ^b   Gray, F ^c   Michel, J B ^b  

^a ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^b INSERM   (France)

^c INSERM U367 ^*  (France)

Author keywords

Hypertension; Nitric oxide; Rats; Spinal cord

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; ASTROCYTE; BLOOD VESSEL TONE; BLOOD VESSEL WALL; BRAIN INFARCTION; CONTROLLED STUDY; DEGENERATION; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; HYPERTENSION; MACROPHAGE; MALE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RAT; SPINAL CORD; STROKE;

AMINO ACID OXIDOREDUCTASES; ANIMALS; ARGININE; ARTERIES; BRAIN; HYPERTENSION; INFARCTION; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; SPINAL CORD;

EID: 0027993474     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/01.STR.25.8.1666     Document Type: Article

References (54)

1. Arnold WP, Mittal CK, Katsuki S, Murad F. Nitric oxide activates guanylate cyclase and increases guanosine 3’:5’-cyclic mono-phosphate levels in various tissue preparations. Proc Natl Acad Sci USA. 1977;74:3203-3207.
2. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524-526.
3. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEBJ. 1992;6:3051-3064.
4. Moncada S, Higgs EA. Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest. 1991;2136 1-374.
5. Murphy S, Simmons ML, Agullo L, Garcia A, Feinstein DL, Galea E, Reis DJ, Minc-Golomb D, Schwartz JP. Synthesis of nitric oxide in CNS glial cells. Trends Neuroscl 1993;16:323-328.
6. Farad FM, Heistad DD. Regulation of cerebral blood vessels by humoral and endothelium-dependent mechanisms: update on humoral regulation of vascular tone. Hypertension. 1991;17:917-922.
7. Rees DD, Palmer RM, Moncada S. The role of endotheliumderived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA. 1989;86:3375-3378.
8. Prado R, Watson BD, Kuluz J, Dietrich WD. Endothelium-derived nitric oxide synthase inhibition: effects on cerebral blood flow, pial artery diameter, and vascular morphology in rats. Stroke. 1992;23:1118-1124.
9. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 1990;347:768-770.
10. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991;351:714-718.
11. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH. Nitric oxide synthase protein and mRNA are discretety localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 1991;7:615-624.
12. Valtschanoff JG, Weinberg RJ, Rustioni A. NADPH diaphorase in the spinal cord of rats. J Comp Neurol 1992;21:209-222.
13. Terenghi G, Riveros-Moreno V, Hudson LD, Ibrahim NBN, Polak JM. Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal ganglia of man and rat. J Neurol Sci. 1993;118:34-37.
14. Schmidt HHHW, Gagne GD, Nakane M, Pollock JS, Miller MF, Murad F. Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanyryl cyclase, and novel para novel functions for nitrinergic signal transduction. J Histochem Cytochem. 1992;40:1439-1456.
15. Nakane M, Ichikawa M, Deguchi T. Light and electron microscopic demonstration of guanylate cyclase in rat brain. Brain Res. 1983;273:9-15.
16. Togashi H, Sakuma I, Yoshioka M, Kobayashi T, Yasuda H, Kitabake A, Saito H, Gross SS, Levi R. A central nervous system action of nitric oxide in blood pressure regulation. J Pharmacol Exp Ther. 1992;262:343-347.
17. Faraci FM, Breese KR. Nitric oxide mediates vasodilatation in response to activation of A’-methyl-D-aspartate receptors in brain. Ore Res.1993;72:476-480.
18. Toda N, Ayajiki K, Okamura T. Neural mechanism underlying basilar arterial constriction by intracistemal L-NNA in anesthetized dogs. Am J PhysioL 1993;265:H103-H107.
19. Toda N, Okamura T. Role of nitric oxide in neuralh/ induced cerebroarterial relaxation. J Pharmacol Exp Ther. 1991;258:1027-1032.
20. Faraci FM, Brian JEJ. Nitric oxide and the cerebral circulation. Stroke. 1994;25:692-703.
21. Okamoto K, Yamori Y, Nagaoka A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res. 1974;34/35(suppl I):I-143-I-153.
22. Yamori Y, Horie R, Akiguchi I, Kihara M, Nara Y, Lovenberg W. Symptomatical classification in the development of stroke in stroke-prone spontaneously hypertensive rats. Jpn Circ J. 1982;46:274-283.
23. Rees DD, Schulz R, Hodson HF, Palmer RMJ, Moncada S. Identification of some novel inhibitors of the vascular nitric oxide synthase in vivo and in vitro. In: Moncada S, Higgs EA, eds. Nitric Oxide From L-Arginine: A Bioregulatory System. Amsterdam, the Netherlands: Elsevier Science Publishing Co, Inc; 1990:485- 487.
24. Peterson DA, Peterson DC, Archer S, Weir EK. The nonspecificity of specific nitric oxide synthase inhibitors. Biochem Biophys Res Commun. 1992;187:797-801.
25. Lambert LE, Whitten JP, Baron BM, Cheng HC, Doherty NS, McDonald IA. Nitric oxide synthesis in the CNS, endothelium and tnacrophages differs in its sensitivity to inhibition by arginine analogues. Life Sci 1991;48:69-75.
26. Arnal J-F, Warm L, Michel J-B. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J Clin Invest 1992;90:647-652.
27. j. Immunology. 1985;4:589-599.
28. Gabbiani G, Schmid E, Winter S, Chaponnier C, de Chastonnay C, Vandekerkhove J, Webert K, Franck WW. Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin. Proc Natl Acad Sci USA. 1981;78:298-302.
29. Cordell JL, Falini B, Erbcr WN, Gash AK, Abdulaziz Z. MacDonald S. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP method). J Histochem Cytochem. 1984;32:219-229.
30. Kaplan E, Meier P. Non parametric estimation from incomplete observations, J Am Sut Assoc, 1958;53:457-481.
31. Baylis C, Mitruka B, Deng A, Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomeralar damage. J Clin Invest. 1992;90:278-281.
32. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zalz R. Chronic inhibition of nitric oxide synthesis: a new model of arterial hypertension. Hypertension. 1992;20:298-303.
33. Morton JJ, Beattie EC, Speins A, Gulliver F, Persistent hypericnsion following inhibition of nitric oxide formation in the young Wistar rat: role for renin and vascular hypertrophy. J Hypertens. 1993;ll:1083-1088.
34. Graham Dl. Hypoxia and vascular disorders. In: Hume AJ, Duchen LW, eds. Greenfield’s Neuropathology London, England: Edward Arnold Publishers, Ltd; 1992:153-268.
35. Fredriksson K, Auer RN, Kalimo H, Nordborg C, Olsson Y, Johansson BB. Cerebrovascular lesions in stroke-prone spontaneously hypertensive rats. Acta Neuwpathol (Bed). 1985;68:284-294.
36. Tagami M, Nara Y, Kubota A, Sunaga T, Maezawa H, Fujino H, Yamori Y. Ultrastructural characteristics of occluded perforating arteries in stroke-prone spontaneously hypertensive rats. Stroke. 1987;18:733-740.
37. Tagami M, Kubota A, Kitamura J, Nara Y, Yamori Y. Electron microscopic studies of ruptured and occluded arteries in stroke-prone spontaneously hypertensive rats. J Hypertens. 1986; 4(suppl 3):S413-S415.
38. Steiner AL, Ferrendelli JA, Kipnis DM. Radioimmunoassay for cyclic nucleotides. J Biol Chem. 1972;247:1121-1124.
39. Garthwaite J, Garthwaite G, Palmer RMJ, Moncada S. NMDA receptor activation induces nitric oxide synthesis from argininc in rat brain slices. Eur J Pharmacol 1989;172:413-416.
40. Kontos HA. Nitric oxide and nitrosothiols in cerebrovascular and neuronal regulation. Stroke. 1993;24(suppl I):I-155-I-158.
41. Wu W, Li L. Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion. Neurosci Lett. 1993;153:121-124.
42. c-Nitro-L-arginine methyl ester and other alkyl esters of arguiine are muscarinic receptor antagonists. Ore Res. 1993;72:387-395.
43. Gaily JA, Read Montague P, Reeke JNJ, Edelman GM. The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system. Proc Natl AcadSciUSA. 1990;87:3547-3551.
44. Hope BT, Michael GJ, Knigge KM, Vincent SR. Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA. 1991;88:2811-2814.
45. Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH. Possible origins and distribution of immu-noreactive nitric oxide synthase-containing nerve fibers in rat and human cerebral arteries. J Cereb Blood Flow Metab. 1993;13:70-79.
46. Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann NeuroL 1992;32:297-311.
47. Tanaka K, Fukuuchi Y, Gomi S, Mihara B, Shirai T, Nogawa S, Nozaki H, Nagata E. Inhibition of nitric oxide synthesis impairs autoregulation of local cerebral blood flow in the rat. Ncumreport. 1993;4:267-270.
48. Tanaka K, Gotoh F, Gomi S. Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat. Neurosci Lett. 1991;127:129-132.
49. Faraci FM. Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol 1990;255:H1216-H1221.
50. Iadecola C. Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link? Trends Neurosci 1993;16:206-214.
51. Kovach AGB, Szabo C, Benyo Z, Csaki C, Greenberg JH, RerWch M. Effects of N°-nitro-L-arginuie and L-arginine on regional cerebral blood flow in the cat. J Physio! (Lond). 1992;449:183-196.
52. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pat ho physiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
53. Garg UC, Hassid A. Nitric oxide generating vasodilators and 8-bromo cyclic GMP inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774-1777.
54. Radomski NW, Palmer RMJ, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987;338:1057-1058.