E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

Cell

Volumn 79, Issue 5, 1994, Pages 885-892

  Bain, Gretchen ^a   Maandag, Els C Robanus ^b   Izon, David J ^b   Amsen, Derk ^b   Kruisbeek, Ada M ^b   Weintraub, Bennett C ^a   Krop, Ian ^d   Schlissel, Mark S ^d   Feeney, Ann J ^c   van Roon, Marian ^b   van der Valk, Martin ^b   te Riele, Hein P J ^b   Berns, Anton ^b   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HOMOZYGOSITY; IMMUNOGENETICS; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ANIMALIA;

EID: 0027992622     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90077-9     Document Type: Article

References (53)

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2. H rearrangement by promoter-enhancer approximation
3. Development of the primary antibody repertoire
4. Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta-cells and lymphocytes
5. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
6. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
7. H locus
8. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
9. Cell type specific contacts to immunoglobulin enhancers in nuclei
10. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
11. B-lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo
12. Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells
13. Lack of N regions in fetal and neonatal mouse immunoglobulin V-d-J junctional sequences
14. H junctions occuring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies
15. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate
16. Resolution and characterization of pro-B and pre- pro-B cell stages in normal mouse bone marrow
17. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germ line colonization by cultured cells
18. E2A expression nuclear localization and in vivo formation of DNA- and non-DNA-binding species during B-cell development
19. Recombination fragment assay for gene targeting based on the PCR reaction assay
20. A critical role of λ5 protein in B cell development
21. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP
22. Characterization of a monoclonal antibody which detects all murine alpha-beta T cell receptors
23. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
24. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility
25. μ-containing transcripts initiate heterogeneously within the lgH enhancer region and contain a novel 5′-nontranslatable exon
26. RAG-1-deficient mice have no mature B and T lymphocytes
27. A series of mammalian expression vectors and characterization of their expression of a reporter gene in stably and transiently transfected cells
28. A new DNA binding and dimerization motif in immunoglobulin enhancer binding daughterless MyoD and myc proteins
29. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
30. B-cell-and myocyte-specific E2-box-binding factors contain E12/E47-like subunits
31. Structure and function of helix-loop-helix proteins
32. preB1 gene
33. Localization of E2A mRNA expression in developing and adult rat tissues
34. Modulation of the lgH enhancers cell type specificity through a genetic switch
35. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement
36. Helix loop helix transcription factor-E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
37. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription
38. Multiple nuclear factors interact with the immunoglobulin μ chain enhancer sequences
39. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
40. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
41. Restoration of T-cell development in RAG-2 deficient mice by functional TCR transgenes
42. Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells
43. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1 deficient mice
44. The immunoglobulin heavy-chain enhancer functions as the promoter for l-mu sterile transcription
45. Constitutive expression of the Id1 gene impairs mouse B cell development
46. Functional analysis of the murine T-cell receptor β enhancer and characteristics of its DNA-binding proteins
47. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
48. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
49. In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer
50. Identification of a pancreatic β-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific gene expression its possible relationship to other cellular factors that bind to a common insulin gene sequence
51. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation
52. Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis erythropoiesis chondrogenesis or neurogenesis
53. The helix-loop-helix gene E2A is required for B cell formation