The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

Neuroscience

Volumn 62, Issue 1, 1994, Pages 265-271

  Patchev, V K ^a   Shoaib, M ^a   Holsboer, F ^a   Almeida, O F X ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA PREGNANOLONE; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; MESSENGER RNA; METHOXAMINE; TETRAHYDROPROGESTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HORMONE RELEASE; HYPOTHALAMUS; IN SITU HYBRIDIZATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; TISSUE CULTURE;

ANIMAL; ANTI-ANXIETY AGENTS; ANXIETY; CORTICOTROPIN-RELEASING HORMONE; GENE EXPRESSION; HYPOTHALAMUS; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PREGNANOLONE; RATS; RATS, WISTAR; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T;

EID: 0027990941     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(94)90330-1     Document Type: Article

References (48)

1. Sexual dimorphism in regulation of type II corticosteroid receptor immunoreactivity in the rat hippocampus
2. Adrenergic mechanisms in the control of corticotropin secretion
3. Neurosteroids: an overview
4. A receptor
5. Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brain
6. Altered expression of hypothalamic neuropeptide mRNA in food-restricted and food-deprived rats
7. Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin-releasing factor and stress
8. Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test
9. The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone
10. A supramolecular complex
11. Thymic hormone-containing cells. VII. Adrenals and gonads control the in vivo secretion of thymulin and its plasmatic inhibitor
12. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety and stress responses?
13. Anxiolytic and anxiogenic drugs: changes in behaviour and endocrine responses
14. Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers
15. Progestin receptors in the thymus of ovariectomized immature rats
16. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanisms of action
17. Biochemistry, molecular biology, and physiology of the glucocorticoid receptor
18. The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia
19. Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/β-lipotropin precursor mRNA in the pituitary in rats
20. Cloning and sequence analysis of cDNA for rat corticotropin-releasing factor precursor
21. Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice
22. 1-adrenergic receptors in the secretion of hypothalamic corticotropin-releasing hormone during stress
23. The role of corticotropin-releasing factor in behavioural responses to stress
24. Gene expression for estrogen and progesterone receptor mRNAs in rat brain and possible relations to sexually dimorphic functions
25. Progestin receptors in rat brain: distribution and properties of cytoplasmic progestin-binding sites
26. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
27. Second messenger regulation of mRNA for corticotropin-releasing factor
28. CRF-containing neurons in the hypothalamic paraventricular nucleus: regulation, especially by catecholamines
29. Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain
30. Physiology and pharmacology of corticotropin-releasing factor
31. Neuroactive steroids
32. Increased plasma concentrations, hypothalamie content and in vitro release of arginine vasopressin in inflammatory disease-prone, hypothalamic corticotropin-releasing hormone-deficient Lewis rats
33. Adrenalectomy and experimental hypercorticalism modulate the basal, corticotropin-releasing hormone- and arginine-vasopressin-stimulated release of hypothalamic beta-endorphin
34. Regulation of hypophysiotropic actions mediating ACTH secretion
35. Neurosteroids act on recombinant human GABA receptors
36. Synthesis, metabolism and pharma[;cological activity of 3α-hydroxy steroids which potentiate GABA receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes
37. Stress-induced elevations of τ-aminobutyric acid type A receptor-active steroids in the rat brain
38. Mediation by corticotropin-releasing factor (CRF) of adenohypophysial hormone secretion
39. Expression and estrogen regulation of progesterone receptor mRNA in neurons of the mediobasal hypothalamus: an in situ hybridization study
40. Progesterone receptor mediated effects of neurosteroids
41. Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvo-cellular neurosecretory neurons: anatomic, peptide, and steroid specificity
42. Changes in hypothalamo-corticotrope axis after bilateral adrenalectomy: evidence for a median eminence site of glucocorticoid action
43. In vitro study of immunoreactive eorticotropin-releasing factor from the rat hypothalamus
44. Glucocorticoid receptors: evidence for a second non-glucocorticoid binding site
45. Further evidence for a central stimulatory action of catecholamines on adrenocorticotropin release in the rat
46. GABA modulation of CRF-41 secretion from rat hypothalamus in vitro
47. Sexual dimorphism of glucocorticoid binding in rat brain
48. Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy in rats