Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions

Journal of Biological Chemistry

Volumn 269, Issue 46, 1994, Pages 28702-28707

  Leteurtre, François ^a   Fujimori, Akira ^a   Tanizawa, Akihiko ^a,c   Chhabra, Adhuna ^a   Mazumder, Abhijit ^a   Kohlhagen, Glenda ^a   Nakano, Hirofumi ^b   Pommier, Yves ^a,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; SAINTOPIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CROSS RESISTANCE; DNA CLEAVAGE; DNA FLANKING REGION; DRUG DNA INTERACTION; ENZYME ACTIVE SITE; PRIORITY JOURNAL;

BASE SEQUENCE; BENZ(A)ANTHRACENES; CATALYSIS; DNA PRIMERS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HUMANS; HYDROLYSIS; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; TYROSINE;

EID: 0027988123     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Champoux, J. (1990) in DNA Topology and Its Biological Effects (Wang, J. C., and Cozarelli, N. R., eds) pp. 217-242, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
2. Liu, L. F. (1989) Annu. Rev. Biochem. 58, 351-375
3. Wang, J. C. (1987) Biochim. Biophys. Acta 909, 1-9
4. Rose, D., and Holm, C. (1993) Mol. Cell. Biol. 13, 3445-3455
5. Lindsley, J. E., and Wang, J. C. (1993) J. Biol. Chem. 268, 8096-8104
6. Roca, J., and Wang, J. C. (1992) Cell 71, 833-840
7. Robinson, M. J., and Osheroff, N. (1991) Biochemistry 30, 1807-1813
8. Pommier, Y., and Kohn, K. W. (1989) in Developments in Cancer Chemotherapy (Gazer, R. I., ed) pp. 175-196, CRC Press, Inc., Boca Raton, FL
9. Pommier, Y., and Tanizawa, A. (1993) in Cancer Chemotherapy (Hickman, J., and Tritton, T., eds) pp. 214-250, Blackwell Scientific Publications Ltd., Oxford
10. Svejstrup, J. Q., Christiansen, K., Gromova, I. I., Andersen, A. H., and Westergaard, O. (1991) J. Mol. Biol. 222, 669-678
11. Lima, C. D., Wang, J. C., and Mondragon, A. (1994) Nature 367, 138-146
12. Sorensen, B. S., Sinding, J., Andersen, A. H., Alsner, J., Jensen, P. B., and Westergaard, O. (1992) J. Mol. Biol. 228, 778-786
13. Robinson, M. J., Corbett, A. H., and Osheroff, N. (1993) Biochemistry 32, 3638-3643
14. Corbett, A. H., Hong, D., and Osheroff, N. (1993) J. Biol. Chem. 268, 14394-14398
15. Beck, W. T., Danks, M. K., Wolverton, J. S., Kim, R., and Chen, M. (1993) Adv. Enzyme Regul. 33, 113-127
16. Alsner, J., Svejstrup, J. Q., Kjeldsen, E., Sorensen, B. S., and Westergaard, O. (1992) J. Biol. Chem. 267, 12408-12411
17. Pommier, Y., Leteurtre, F., Fesen, M. R., Fujimori, A., Bertrand, R., Solary, E., Kohlhagen, G., and Kohn, K. W. (1994) Cancer Invest. 12, 530-542
18. Capranico, G., Palumbo, M., Tinelli, S., Mabilia, M., Pozzan, A., and Zunino, F. (1994) J. Mol. Biol. 235, 1218-1230
19. Fosse, P., Rene, B., Le Bret, M., Paoletti, C., and Saucier, J.-M. (1991) Nucleic Acids Res. 19, 2861-2868
20. Freudenreich, C. H., and Kreuzer, K. N. (1993) EMBO J. 12, 2085-2097
21. Jaxel, C., Capranico, G., Kerrigan, D., Kohn, K. W., and Pommier, Y. (1991) J. Biol. Chem. 266, 20418-20423
22. Capranico, G., De Isabella, P., Tinelli, S., Bigioni, M., and Zunino, F. (1993) Biochemistry 32, 3038-3046
23. Pommier, Y., Capranico, G., Orr, A., and Kohn, K. W. (1991) Nucleic Acids Res. 19, 5973-5980
24. Pommier, Y., Kohn, K. W., Capranico, G., and Jaxel, C. (1993) in Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy (Andoh, T., Ikeda, H., and Oguro, M., eds) pp. 215-227, CRC Press, Inc., Boca Raton, FL
25. Wassermann, K., Markovits, J., Jaxel, C., Capranico, G., Kohn, K. W., and Pommier, Y. (1990) Mol. Pharmacol. 38, 38-45
26. Yamashita, Y., Kawada, S., Fujii, N., and Nakano, H. (1991) Biochemistry 30, 5838-5845
27. Poddevin, B., Riou, J.-F., Lavelle, F., and Pommier, Y. (1993) Mol. Pharmacol. 44, 767-774
28. Riou, J.-F., Fosse, P., Nguyen, C. H., Larsen, A. K., Bissery, M.-C., Grondard, L., Saucier, J.-M., Bisagni, E., and Lavelle, F. (1993) Cancer Res. 53, 5987-5993
29. Janin, Y. L., Croisy, A., Riou, J.-F., and Bisagni, E. (1993) J. Med. Chem. 36, 3686-3692
30. Larsen, A. K., Grondard, L., Couprie, J., Desoize, B., Comoe, L., Jardillier, J.-C., and Rinu, J.-F. (1993) Biochem. Pharmacol. 46, 1403-1412
31. Fujimori, A., Harker, G., Hoki, Y., Kohlhagen, G., and Pommier, Y. (1994) Proc. Am. Assoc. Cancer Res. 35, 363
32. Minford, J., Pommier, Y., Filipski, J., Kohn, K. W., Kerrigan, D., Mattern, M., Michaels, S., Schwartz, R., and Zwelling, L. A. (1986) Biochemistry 25, 9-16
33. Leteurtre, F., Kohlhagen, G., Fesen, M., Tanizawa, A., Kohn, K., and Pommier, Y. (1994) J. Biol. Chem. 269, 7893-7900
34. Wittig, B., Wölfl, S., Dorbic, T., Vahrson, W., and Rich, A. (1992) EMBO J. 11, 4653-4663
35. Tanizawa, A., Kohn, K. W., and Pommier, Y. (1993) Nucleic Acids Res. 21, 5157-5166
36. Fujii, N., Yamashita, Y., Saitoh, Y., and Nakano, H. (1993) J. Biol. Chem. 268, 13160-13165
37. Leteurtre, F., Fesen, M., Kohlhagen G., Kohn, K. W., and Pommier, Y. (1993) Biochemistry 32, 8955-8962
38. Yu, B., Ichinose, I., Bonham, M., and Zajac-Kaye, M. (1993) J. Biol. Chem. 268, 19586-19592
39. Chou, R., Churchill, J., Flubacher, M., Mapstone, D., and Jones, J. (1990) Cancer Res. 50, 3199-3206
40. Chou, R., Churchill, J., Flubacher, M., Mapstone, D., and Jones, J. (1991) Am. J. Anat. 191, 312-320
41. Pommier, Y., Capranico, G., Orr, A., and Kohn, K. W. (1991) J. Mol. Biol. 222, 909-924
42. Froelich-Ammon, S., Gale, K. C., and Osheroff, N. (1994) J. Biol. Chem. 269, 7719-7725
43. Capranico, G., Kohn, K. W., and Pommier, Y. (1990) Nucleic Acids Res. 18, 6611-6619
44. Spitzner, J. R., and Muller, M. T. (1988) Nucleic Acids Res. 16, 5533-5556
45. Harker, G., Kapoor, R., Slade, D., Fujimori, A., and Pommier, Y. (1994) Proc. Am. Assoc. Cancer Res. 35, 456
46. Kjeldsen, E., Mollerup, S., Thomsen, B., Bonven, B. J., Bolund, L., and Westergaard, O. (1988) J. Mol. Biol. 202, 333-342
47. Thomsen, B., Mollerup, S., Bonven, B. J., Frank, R., Blocker, H., Nielsen, O. F., and Westergaard, O. (1987) EMBO J. 6, 1817-1823
48. Porter, S. E., and Champoux, J. J. (1989) Nucleic Acids Res. 17, 8521-8532
49. Fujii, N., Yamashita, Y., Chiba, S., Uosaki, Y., Saitoh, Y., Tuji, Y., and Nakano, H. (1993) J. Antibiot. (Tokyo) 46, 1173-1174