Determination of itraconazole and its active metabolite in plasma by column liquid chromatography

Therapeutic Drug Monitoring

Volumn 16, Issue 6, 1994, Pages 596-601

  Poirier, Jean Marie ^a   Lebot, Martine ^a   Descamps, Philippe ^b   Levy, Monique ^a   Heymol, Georges ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b Hopital Boucicaut   (France)

Author keywords

Active metabolite; Itraconazole; Liquid chromatography; Therapeutic drug monitoring

Indexed keywords

4 [4 [4 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 2,4 DIHYDRO 2 (3 METHYLBUTYL) 3H 1,2,4 TRIAZOL 3 ONE; ACICLOVIR; AMIKACIN; AMITRIPTYLINE; AMOXICILLIN; AMPHOTERICIN B; ANTIFUNGAL AGENT; BROMAZEPAM; BUPRENORPHINE; CEFTAZIDIME; CHLORMEZANONE; CIPROFLOXACIN; CISAPRIDE; CISPLATIN; CLORAZEPATE; CODEINE; CYCLOSPORIN; DEXCHLORPHENIRAMINE; DRUG METABOLITE; ETHAMBUTOL; FLUCONAZOLE; FLUNITRAZEPAM; FOSFOMYCIN; FUROSEMIDE; GANCICLOVIR; HYDROXYITRACONAZOLE; ISONIAZID; ITRACONAZOLE; METOCLOPRAMIDE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; HUMAN; LIQUID LIQUID EXTRACTION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SPECTROFLUOROMETRY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADMINISTRATION, ORAL; ANTIFUNGAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPARATIVE STUDY; DRUG MONITORING; HUMAN; ITRACONAZOLE; LEUKEMIA; REPRODUCIBILITY OF RESULTS;

EID: 0027987938     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/00007691-199412000-00011     Document Type: Article

References (20)

1. Espinel-Ingroff A, Shadomy S, Gebhart RJ. In vitro studies with R51.211 (itraconazole). Antimicrob Agents Chemother1984;26:5-9.
2. Van Custen J, Van Gerven F, Janssen PAJ. Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models. Rev Infect Dis1987;9:15-32.
3. Dupont B. Itraconazole therapy in aspergillosis: study in 49 patients. J Am Acad Dermatol1990;23:607-14.
4. Van’t Wout JW, Novakova I, Verhagen CAH, et al. The efficacy of itraconazole against systemic fungal infections in neutropenic patients: a randomised comparative study with amphotericin B. J Infect1991;22:45-52.
5. Denning DW, Tucker RM, Hanson LH, Stevens DA. Treatment of invasive aspergillosis with itraconazole. Am J Med1989;86:791-800.
6. Van Peer A, Woestenborghs R, Heykants J, et al. The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects. EurJ Clin Pharmacol1989; 36:423-6.
7. Heykants J, Van Peer A, Van de Velde V, et al. The clinical pharmacokinetics of itraconazole: an overview. Mycoses1989;22:67-87.
8. Tricot G, Joosten E, Boogaetrs MA, et al. Ketoconazole vs itraconazole for antifungal prophylaxis in patients with severe granulocytopenia: preliminary results of two non-randomised studies. Rev Infect Dis1987;9:757-63.
9. Van Custen J. The in vitro antifungal spectrum of itraconazole. Mycoses1989;32:7-13.
10. Woestenborghs R, Lorreyne W, Heykants J. Determination of itraconazole in plasma and animal tissues by high-performance liquid chromatography. J Chromatogr1987; 413:332-7.
11. Babhair SA. High performance liquid chromatography assay of itraconazole in human plasma. J Liq Chromatogr1988; 11:3261-9.
12. Remmel RP. Assay of itraconazole in leukemic patient plasma by reversed-phase small-bore liquid chromatography. J Chromatogr1988;432:388-94.
13. Warnock DW, Turner A, Burke J. Comparison of high performance liquid chromatographic and microbiological methods for determination of itraconazole. J Antimicrob Chemother1988;21:93-100.
14. Badcock NR. Micro-scale method for itraconazole in plasma by reversed-phase high-performance liquid chromatography. J Chromatogr1990;525:478-83.
15. Allenmark S, Edebo A, Lindgren K. Determination of itraconazole in serum with high-performance liquid chromatography and fluorescence detection. J Chromatogr1990;532: 203-6.
16. Smith DE, Midgley J, Allan M, et al. Itraconazole versus ketoconazole in the treatment of oral and oesophageal can-didosis in patients infected with HIV. AIDS1991;5:1367-71.
17. Wishart JM. The influence of food on the pharmacokinetics of itraconazole in patients with superficial fungal infection. J Am Acad Dermatol1987;17:220-3.
18. Smith D, Van de Velde V, Woestenborghs R, Gazzard BG. The pharmacokinetics of oral itraconazole in AIDS patients. J Pharm Pharmacol1992;44:618-9.
19. Hardin TC, Graybill JR, Fetchick R, et al. Pharmacokinetics of itraconazole following oral administration to normal volunteers. Antimicrob Agents Chemother1988;32:1310-3.
20. Lake-Bakaar G, Winston T, Lake-Bakaar D, et al. Gastrop-athy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med1988;109: 471-3.