-
7
-
-
0020631378
-
Modifications of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding ability towards anti-serum to the enzyme activity
-
659, 67
-
(1983)
Biochem Biophys Commun
, vol.111
-
-
Koide, A.1
Kobayashi, S.2
-
8
-
-
0021015864
-
Enzyme therapy II. Effect of covalent attachment of polyethylene glycol on biochemical parameters and immunological determinants of beta-glucosidase and α-galactosidase
-
337, 47
-
(1983)
J Appl Biochem
, vol.5
-
-
Weider, K.J.1
Davis, F.F.2
-
20
-
-
0019372191
-
Suppression of reaginic antibodies with modified allergens. III. Preparation of tolerogenic conjugates of common allergens with monomethoxypolyethylene glycols of different molecular weights by the mixed anhydride method
-
(1981)
Int Arch Appl Immunol
, vol.64
, pp. 84-99
-
-
Wie, S.I.1
Wie, C.W.2
Lee, W.Y.3
-
23
-
-
0023883750
-
Preparation of polyethylene glycol tissue plasminogen activator adducts that retain functional activity: characteristics and behaviour in three animal species
-
1641, 7
-
(1988)
Blood
, vol.71
-
-
Berger, H.1
Pizzo, S.V.2
-
27
-
-
85025885070
-
-
Hakimi J, Rosen P. Polyethylene glycol protein conjugates. 1992 European Patent Application Number 92104729.6
-
-
-
-
29
-
-
84951694838
-
-
Thompson RC, Armes LG, Evans RJ, et al. Pegylation of polypeptides. 1992 International Patent Application Number WO 92/16221
-
-
-
-
30
-
-
0020617905
-
Modification of batroxobin with activated polyethylene glycol: reduction of binding ability towards anti-batroxobin and retention of defibrinogenation activity in the circulation of preimmunized dogs
-
1467, 73
-
(1985)
Life Sci
, vol.33
-
-
Nishimura, H.1
Takahashi, K.2
Sakurai, K.3
-
36
-
-
0020607315
-
A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of Superoxide dismutase, lactoferrin and alpha 2-macroglobulin
-
(1983)
Anal Biochem
, vol.131
, pp. 25-33
-
-
Beauchamp, C.O.1
Gonias, S.L.2
Menopacer, D.P.3
-
41
-
-
0018755543
-
Experimental enzyme therapy: suppression of allergic reactions in preimmunized animals by administration of exogenous enzymes in the form of dextran conjugates
-
(1979)
J Appl Biochem
, vol.1
, pp. 88-94
-
-
Marshall, J.1
Humphreys, J.2
-
45
-
-
0019275185
-
Modification of haemoglobin upon covalent coupling to dextran-enhanced stability against acid denaturation and reduced affinity for haptoglobin
-
732, 6
-
(1980)
Can J Biochem
, vol.58
-
-
Tarn, S.C.1
Wong, T.F.2
-
46
-
-
0025300389
-
Reduction of immunogenicity by covalent modification of murine and rabbit immunoglobulins with oxidised dextrans of low molecular weight
-
3638, 45
-
(1990)
Cancer Res
, vol.50
-
-
Fagnani, R.1
Hagan2
Bartholomew, R.3
-
50
-
-
84951694842
-
-
Ginger LG, Mather AN. Streptokinase chemically bonded to a carbohydrate matrix. 1980 US patent no. 3639213
-
-
-
-
52
-
-
84951694843
-
-
Ida Y, Kitamura M, Chikamori L, et al. Urokinase derivative and its production method. Japanese patent no. 113488
-
-
-
-
59
-
-
0026512810
-
Evaluation of antibody-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug-carriers. 2.Body distribution of anti Thy-1.2 antibody, anti-transferrin receptor antibody B3/25 and transferrin conjugates in DBA2 mice and activity of conjugates containing daunomycin against L1210 leukaemia in vivo
-
(1992)
J Controlled Release
, vol.18
, pp. 25-38
-
-
Flanagan, P.A.1
Kopeckova, P.2
Subr, V.3
-
65
-
-
84951694846
-
-
Hashida M, Takakura Y, Matsumoto S, et al. Development of macromolecular prodrugs of mitomycin C suitable for local injected therapy. Proceedings of the International Congress on Chemotherapy, Kyoto; 1985: 357–8
-
-
-
-
71
-
-
84951694847
-
-
Decher G, Emmelius M, Ringsdorf H. Synthesis and antitumour activity of daunorubicine-containing polymers. Abstract presented at the 26th Microsymposium on Polymers in Medicine and Biology, Prague Czechoslovakia 1984; 40–1
-
-
-
-
75
-
-
0025874282
-
Toxicity and antitumour activity against solid tumours of micelle-forming polymeric anticancer drug and its extremely long circulation in blood
-
3229, 36
-
(1991)
Cancer Res
, vol.51
-
-
Yokoyama, M.1
Okano, T.2
Sakurai, Y.3
-
79
-
-
84951694848
-
-
Horpel G, Klesse W, Ringsdorf H, et al. Micelle forming coand block copolymers for sustained drug release. IUPAC Proceedings of the International Symposium on Macromolecules, Amherst, Massachusetts 1982; 346
-
-
-
-
99
-
-
0026118760
-
SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
-
(1991)
Adv Drug Delivery Rev
, vol.6
, pp. 181-202
-
-
Maeda, H.1
-
100
-
-
0021908189
-
Conjugation of poly(sty-rene-co-maleic acid) derivatives to the antitumour protein neocarzinostatin: Pronounced improvements in pharmacological properties
-
455, 61
-
(1985)
J Med Chem
, vol.28
-
-
Maeda, H.1
Ueda, M.2
Morinaga, T.3
-
101
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy; mechanism of tumoritropic accumulation of proteins and the antitumour agent SMANCS
-
6387, 92
-
(1986)
Cancer Res
, vol.6
-
-
Matsumura, Y.1
Maeda, H.2
-
106
-
-
0021354472
-
Controlled biodegradability of polymers — key to drug delivery systems
-
(1984)
Biomaterials
, vol.5
, pp. 19-25
-
-
Kopecek, J.1
-
117
-
-
84951694852
-
-
Mattijssen V, de Mulder PHM, van den Broek P, et al. Intratumoural immunotherapy with PEG-IL2, preclinical and clinical studies. Abstract from the 4th International Conference of Anticancer Research. Greece 1992; 1872
-
-
-
-
122
-
-
84912874082
-
Perirenal transplant quantitation of free radical scavenger enzyme activity (FRSEA)- the effect of a single dose of PEG-SOD and renal failure
-
abstract
-
(1990)
J Urology
, vol.143
, pp. 287A
-
-
Bretan, P.N.1
Pipperger, C.E.2
Meng, X.3
-
128
-
-
0026118764
-
Preparation, in vivo properties, and proposed clinical use of polyoxyethylene-modified tissue plasminogen activator and streptokinase
-
153, 66
-
(1991)
Adv Drug Delivery Rev
, vol.6
-
-
Pizzo, S.V.1
-
129
-
-
0027253357
-
The conjugation of proteins with polyethylene glycol and other proteins. Altering properties of proteins to enhance their therapeutic potential
-
(1993)
Adv Drug Delivery Rev
, vol.10
, pp. 91-114
-
-
Katre, N.V.1
-
132
-
-
0023683508
-
Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
-
15064, 70
-
(1988)
J Biol Chem
, vol.263
-
-
Knauf, M.J.1
Bell, D.P.2
Hirtzer, P.3
-
136
-
-
0023450012
-
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distributions and rate of excretion after subcutaneous intraperitoneal and intravenous administration to rats
-
1341, 58
-
(1987)
J Biomed Mater Res
, vol.21
-
-
Seymour, L.W.1
Duncan, R.2
Strohalm, J.3
-
137
-
-
85025893379
-
-
Seymour LW, Miyamoto Y, Maeda H, et al. Influence of molecular weight on passive tumour-accumulation of a soluble macromolecular drug-carrier. Eur J Cancer. In press
-
-
-
-
139
-
-
0028158713
-
Evaluation of poly(glutamic acid, alanine, tyrosine) (1:1:1) as a lung-specific drug delivery system. 1. Biocompatibility and studies on biodistribution in the rat. S.T.P
-
(1994)
Pharma Sciences
, vol.4
, pp. 87-94
-
-
Sgouras, D.N.F.1
Duncan, R.2
-
150
-
-
85025907450
-
-
Seymour LW, Ulbrich K, Strohalm J, et al. Studies on the tumour kinetics of doxorubicin delivered as a soluble conjugate with N-(2-hydroxypropyl)methacrylamide copolymers. Second European Symposium on Controlled Drug Delivery; April 1–3 1992: Noordwijk Aan Zee, Netherlands, 1992
-
-
-
-
153
-
-
0024398880
-
Biocompatibility of N-(2-hydroxypropyl)methacrylamide copolymers containing adriamycin. Immunogenicity, effect on haematopoietic stem cells in bone marrow in vivo and effect of mouse splenocytes and human peripheral blood lymphocytes in vitro
-
335, 42
-
(1989)
Biomaterials
, vol.10
-
-
Rihova, B.1
Ulbrich, K.2
Strohalm, J.3
-
154
-
-
0026603586
-
Selective tumor localisation and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
-
891, 6
-
(1992)
Cancer Res
, vol.52
-
-
Gabizon, A.1
-
156
-
-
0027831928
-
Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies
-
152, 31
-
(1993)
J Drug Targeting
, vol.1
-
-
Pimm, M.V.1
Perkins, A.C.2
Duncan, R.3
-
157
-
-
0025855856
-
Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers following intravenous administration in the rat
-
546, 9
-
(1991)
Br J Cancer
, vol.63
-
-
Wedge, S.R.1
Duncan, R.2
Kopeckova, P.3
|