A Randomized Controlled Trial of Influenza Vaccine in the Elderly: Scientific Scrutiny and Ethical Responsibility

JAMA: The Journal of the American Medical Association

Volumn 272, Issue 21, 1994, Pages 1700-1701

  Patriarca, Peter A ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE;

AGED; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EDITORIAL; ELDERLY CARE; HUMAN; INFECTION PREVENTION; INFLUENZA; INFLUENZA VACCINATION; MEDICAL ETHICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPONSIBILITY;

EID: 0027987224     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1994.03520210084039     Document Type: Article

References (19)

1. Couch RB, Kasal TR, Glezen WP, et al. Influenza: its control in persons and populations. J Infect Dis. 1986;153:431-440.
2. Glezen WP. Serious morbidity and mortality associated with influenza epidemics. Epidemiol Rev. 1982;4:25-44.
3. Williams WW, Hickson MA, Kane MA, Kendal AP, Spika JS, Hinman AR. Immunization policies and vaccine coverage among adults: the risk of missed opportunities. Ann Intern Med. 1988;108:616-625.
4. Strassburg MA, Greenland S, Sorvillo FJ, Lieb LE, Habel LA. Influenza in the elderly: report of an outbreak and a review of vaccine effectiveness reports. Vaccine. 1986;4:38-44.
5. Eickhoff TC, Sherman IL, Serfling RE. Observations on excess mortality associated with epidemic influenza. JAMA. 1961;176:776-782.
6. Advisory Committee on Immunization Practices (ACIP). Prevention and Control of influenza: part I, vaccines. MMWR Morb Mortal Wkly Rep. 1994;43(RR-9):1-13.
7. Dutch Health Council Committee on Vaccination Against Influenza. Vaccination Against Influenza: 1991-1992 Season. The Hague, the Netherlands: Dutch Health Council; 1991:15.
8. Monto AS. Influenza vaccines for the elderly. N Engl J Med. 1994;331:807-808.
9. Govaert ThME, Thijs CTMCN, Masurel N, Sprenger MJW, Dinant GJ, Knottnerus JA. The efficacy of influenza vaccination in elderly individuals: a randomized double-blind placebo-controlled trial. JAMA. 1994;272:1661-1665.
10. Barker WH, Mullooly JP. Effectiveness of inactivated influenza vaccine among non-institutionalized elderly persons. In: Kendal AP, Patriarca PA, eds. Options for the Control of Influenza. New York, NY: Alan R Liss Inc; 1986:169-182.
11. Patriarca PA, Weber JA, Parker RA, et al. Efficacy of influenza vaccine in nursing homes: reduction in illness and complications during an influenza A (H3N2) epidemic. JAMA. 1985;253:1136-1139.
12. Saah AJ, Neufield R, Rodstein M, et al. Influenza vaccine and pneumonia mortality in a nursing home population. Arch Intern Med. 1986;146:2353-2357.
13. Gross PA, Quinnan GV, Rodstein M, et al. Association of influenza immunization with reduction in mortality in an elderly population. Arch Intern Med. 1988;148:562-565.
14. Couch RB. Advances in influenza virus vaccine research. Ann N Y Acad Sci. 1993;685:803-812.
15. Couch RB, Kasal JA. Immunity to influenza in man. Annu Rev Microbiol. 1983; 37:529-549.
16. Gross PA, Hermogenes A, Sacks HS, Levandowski RA. The protective efficacy of influenza vaccine in the elderly: a meta-analysis. In: Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy (October 7, 1994; Orlando, Fla). Washington, DC: American Society for Microbiology; 1994:265.
17. Nichol KL, Margolis KL, Wuorenma J, Von Sternberg T. The efficacy and cost-effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med. 1994;331:778-784.
18. Mullooly JP, Bennett MD, Hornbrook MC, et al. Cost-effectiveness of influenza programs for the elderly in a health maintenance organization. Ann Intern Med. In press.
19. Office of Technology Assessment. Cost-effectiveness of Influenza Vaccination. Washington, DC: Office of Technology Assessment; 1981.