Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases

Biochemical Pharmacology

Volumn 48, Issue 10, 1994, Pages 1979-1981

  Alanko, Juha ^a   Kurahashi, Yuko ^a   Yoshimoto, Tanihiro ^a   Yamamoto, Shozo ^a   Baba, Kimiye ^a,b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

arachidonic acid; cyclooxygenase; falcarindiol; leukocytes; platelets

Indexed keywords

FALCARINDIOL; ISOENZYME; LIPOXYGENASE; PANAX NOTOGINSENG EXTRACT; PANAXYNOL; PLANT EXTRACT; POLYACETYLENE DERIVATIVE; PROSTAGLANDIN SYNTHASE; SAPOSHNIKOVIAE RADIX EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME INHIBITION; HERBAL MEDICINE; HUMAN; HUMAN CELL; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SHEEP; SWINE; THROMBOCYTE;

ANIMAL; DRUGS, CHINESE HERBAL; FATTY ALCOHOLS; HUMAN; LIPOXYGENASE INHIBITORS; SHEEP; SUPPORT, NON-U.S. GOV'T;

EID: 0027985790     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90598-3     Document Type: Article

References (12)

1. Studies on Chinese traditional medicine “Fang-Feng” (I) Structures and physiological activities of polyacetylene compounds from Saposhnikoviae radix
2. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng
3. Enzymes in the arachidonic acid cascade
4. “Enzymatic” lipid peroxidation: reactions of mammalian lipoxygenases
5. Mammalian lipoxygenases: molecular structures and functions
6. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
7. Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties
8. The Lipoxygenase of Reticulocytes. Purification, Characterization and Biological Dynamics of the Lipoxygenase; Its Identity with the Respiratory Inhibitors of the Reticulocyte
9. Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity and its reactivity with hydroperoxyeicosatetraenoic acid
10. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acid
11. Enzyme inhibition by acetylenic compounds
12. 4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes