Human papillomaviruses

Annual Review of Microbiology

Volumn 48, Issue , 1994, Pages 427-447

  Zur Hausen, Harald Z ^a   De Villiers, Ethel Michele ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

cell immortalization; cervical cancer; genetic instability; HPV epidemiology; malignant progression

Indexed keywords

CELL IMMORTALIZATION; CELL TRANSFORMATION; HUMAN; IMMUNE RESPONSE; PAPILLOMA VIRUS; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH; UTERINE CERVIX CANCER; VIRUS DETECTION; VIRUS INFECTION; WART VIRUS;

CANCER VIRUS; HUMAN PAPILLOMAVIRUS TYPES; PAPILLOMAVIRUS;

EID: 0027985695     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.mi.48.100194.002235     Document Type: Review

References (123)

1. Archard H, Heck J, Stanley H. 1965. Focal epithelial hyperplasia: an unusual oral mucosal lesion found in Indian children. Oral Surg. 20:201-12
2. Band V, De Caprio JA, Delmolina L, Kulesa V, Sager R. 1991. Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J. Virol. 65:6671-76
3. Band V, Zaychowski D, Kulesa V, Sager R. 1990. Human papillomavirus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc. Natl. Acad. Sci. USA. 87:463-67
4. Barr BBB, Beriton EC, McLaren K, Bunney MH, Smith JW, et al. 1988. Human papillomavirus infection in skin cancer in renal allograft recipients. Lancet 1:124-29
5. Bartsch D, Boye B, Baust C, zur Hausen H, Schwarz E. 1992. Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor β gene in non-tumorigenic and tumorigenic HeLa hybrid cells. EMBO J. 11:2283-91
6. Bauknecht T, Angel P, Royer H-D, zur Hausen H. 1992. Indentification of a negative regulatory domain in the human papillomavirus type 18 promoter: intersection with the transcriptional repressor YY1. EMBO J. 11:4607-17
7. Beaudenon S, Praetorius F, Kremsdorf D, Lutzner M, Worsaae N, et al 1987. A new type of human papillomavirus associated with oral focal epithelial hyperplasia. J. Invest. Dermatol. 88:130-35
8. Bernard HU, Chan SY, Delius H. 1994 Evolution of papillomaviruses. Curr. Top. Microbiol. Immunol. 86:34-53
9. Böhm S, Wilczynski SP, Pfister H, Iftner T. 1993. The predominant m-TNA class in HPV 16-infected genital neoplasias does not encode the E6 or the E7 protein. Int. J. Cancer 55:791-98
10. Boiron M, Levy JP, Thomas M, Friedman JC, Bernard J. 1964. Some properties of bovine papilloma virus. Nature 201:423-24
11. Bosch F, Schwarz E, Boukamp P, Fusenig NE, Bartsch D, zur Hausen H. 1990. Suppression in vivo of human papillomavirus type 18 E6-E7 gene expression in nontumorigenic HeLafibroblast hybrid cells. J. Virol. 64:4743-54
12. Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Sheurlen W, zur Hausen H. 1984. A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 3:1151-57
13. Brandsma JL, Abramson AL. 1989. Association of papillomavirus with cancers of the head and neck. Arch. Otolaryngol. 115:621-25
14. Byrne JC, Tsao MS, Fraser RS, Howley PM. 1987. Human papillomavirus 11 DNA in a patient with chronic laryngotrachiobronchial papillomatosis and metastatic squamous cell carcinoma of the lung. New Eng. J. Med. 317:873-78
15. Chang F, Syrjänen S, Nuntinen J, Kärjä J, Syrjänen K. 1990. Detection of human papillomavirus (HPV) DNA in oral squamous cell carcinomas by in situ hybridization and polymerase reaction. Arch. Dermatol. Res. 282:493-97
16. Chang F, Syrjänen S, Syrjänen K. 1993. Demonstration of human papillomavirus (HPV) type 30 in esophageal squamous-cell carcinomas by in situ hybridization. Int. J. Cancer 55:171-73
17. Chang F, Syrjänen S, Wang L, Syrjänen K. 1992. Infectious agents in the etiology of esophageal cancer. Gastroenterology 103:1336-48
18. Chang SE. 1986. In vitro transformation of human epithelial cells. Biochim. Biophys. Acta 823:161-94
19. Chen T-M, Pecoraro G, Defendi V. 1993. Genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells. Cancer Res. 53:1167-71
20. Connor ME, Stern PL. 1990. Loss of MHC class 1 expression in cervical carcinomas. Int. J. Cancer 46 :1029-34
21. Cromme FV, Meijer CJLM, Snijders PJF, Uyterlinde A, Kenemans P, et al. 1993. Analysis of MHC class I and II expression in relation to presence of HPV genotypes in pre-malignant and malignant cervical lesions. Br. J. Cancer 67:1372-80
22. Cromme FV, Snijders PJ, van den Brule AJC, Kenemans P, Meijer CJLM, Walboomers JMM. 1993. MHC class 1 expression in HPV 16 positive cervical carcinomas is post-transcriptionally controlled and independent from c-myc overexpression. Oncogene 8:2969-75
23. Crook, T, Morgenstern JP, Crawford L, Banks L. 1989. Continued expression of HPV 16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV 16 plus EJ-ras. EMBO J. 8:513-19
24. Crook T, Storey A, Almond D, Osborn K, Crawford L. 1988. Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells. Proc. Natl. Acad. Sci. USA 85:8820-24
25. Crook T, Wrede D, Vousden K. 1991. p53 point mutation in HPV negative human cervical carcinoma cell lines. Oncogene 6:873-75
26. Crum CP. 1992. Carcinoma of the vulva: epidemiology and pathogenesis. Obstet. Gynecol. 79:448-54
27. Das BC, Gopalkriscna, Das DK, Sharma JK, Singh V, Luthra UK. 1993. Human papillomavirus DNA sequences in adenocarcinoma of the uterine cervix in Indian women. Cancer 72:147-53
28. Delius H, Hofmann B. 1994. Primer-directed sequencing of human papillomavirus types. Curr. Top. Microbiol. Immunol. 86:13-31
29. de Villiers E-M. 1989. Papillomaviruses in cancers and papillomas of the aerodigestive tract. Biomed. Pharmacother. 43:31-36
30. de Villiers E-M. 1994. Human pathogenic papillomaviruses: an update. Curr. Top. Microbiol. Immunol. 86:1-12
31. de Villiers E-M, Wagner D, Schneider A, Wesch H, Miklaw H, Wahrendorf J, et al. 1987. Human papillomavirus infection in women with and without abnormal cervical cytology. Lancet 2:703-6
32. de Villiers E-M, Weidauer H, Otto H, zur Hausen H. 1985. Papillomavirus DNA in human tongue carcinomas. Int. J. Cancer 36:575-78
33. DiLorenzo TP, Tamsen A, Abramson AL, Steinberg BM. 1992. Human papillomavirus type 6a DNA in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is charcterized by a partial duplication. J. Gen Virol. 73:423-28
34. DiPaolo JA, Woodworth CD, Popescu NC, Koval DL, Lopez JV, Doniger J. 1990. HSV-2-induced tumorigenicity in HPV 16-immortalized human genital keratinocytes. Virology 177:777-79
35. DiPaolo JA, Woodworth CD, Popescu NC, Notario V, Doniger J. 1989. Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral ras. Oncogene 4:395-99
36. Donehower LA, Harvey M, Hagle BL, McArthur MJ, Montgomery CA Jr, et al. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215-21
37. Drews RE, Chan VT-W, Schnipper LE. 1992. Oncogenes result in genomic alterations that activate a transcriptionally silent dominantly selectable reporter gene (neo). Mol. Cell. Biol. 12:198-206
38. Dürst M., Bosch FX, Glitz D, Schneider A, zur Hausen H. 1991. Inverse relationship between human papillomvirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV positive human cell lines. J. Virol. 65:796-804
39. Dürst M, Dzarlieva-Petrusevska RT, Boukamp P, Fusenig NE, Gissmann L. 1987. Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene 1:251-56
40. Dürst M, Gallahan D, Jay G, Rhim JS. 1989. Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene. Virology 173:767-71
41. Durst M, Gissmann L, Ikenberg H, zur Hausen H. 1983. A new papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80:3812-15
42. Durst M, Glitz D, Schneider A, zur Hausen H. 1992. Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: analysis by in situ hybridization. Virology 189:132-40
43. Egan SE, Weinberg RA. 1993. The pathway to signal achievement. Nature 365:781-83
44. Euvrard S, Chardonnet Y, Pouteil-Noble C, Kanitakis J, Chignol MC, et al. 1993. Association of skin malignancies with various and multiple carcinogenic and noncarcinogenic human papillomavirus in renal transplant recipients. Cancer 72:2198-2206
45. Fairley CK, Chen S, Tabrizi SN, Leeton K, Quinn MA, Garland SM. 1992. The absence of genital human papillomavirus DNA in virginal women. Int. J. STD AIDS 3:414-17
46. Friedmann JM, Fialkow PJ. 1976. Viral "tumorigenesis" in man: cell markers in condylomata acuminata. Int. J. Cancer 17:57-61
47. Fu Y-S, Braun L, Shah KV, Lawrence WP, Robboy SJ. 1983. Histologic, nuclear DNA and human papillomavirus studies of cervical condylomas. Cancer 52:1705-11
48. Fu Y-S, Reagan JW, Richart RM. 1981. Definition of precursors. Gynecol. Oncol. 12:220-31
49. Furihata M, Ohtsuki Y, Ogoshi S, Takahashi A, Tamiya T, Ogata T. 1993. Prognostic significance of human papillomavirus genomes (type-16, -18) and aberrant expression of p53 protein in human esophageal cancer. Int. J. Cancer 54:226-30
50. Gissmann L, Pfister H, zur Hausen H. 1977. Human papilloma viruses (HPV): characterization of four different isolates. Virology 76:569-80
51. Gissmann L, zur Hausen H. 1976. Human papilloma viruses: physical mapping and genetic heterogeneity. Proc. Natl. Acad. Sci. USA 73:1310-13
52. Glew SS, Stern PL. 1992. HLA antigens and cervical carcinoma. Nature 356:22
53. Gomez A, Calle C, Arala G, Pindborg JT. 1969. Focal epithelial hyperplasia in a half-breed familial of Colombians. J. Am. Dent. Assoc. 79:663-67
54. Greenhalgh DA, Welty DJ, Player A, Yuspa SH. 1990. Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma. Proc. Natl. Acad. Sci. USA 87:643-47
55. Gutman LT, Claire K, Herman-Giddens ME, Johnston WW, Phelps WC. 1992. Evaluation of sexually abused and non-abused young girls for intravaginal human papillomavirus infection. Am. J. Dis. Child. 146:694-99
56. Halbert CL, Demers, GW, Galloway DA. 1991. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J. Virol. 65:473-78
57. Han R, Breitburd F, Marche PN, Orth G. 1992. Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes. Nature 356:66-68
58. Helland A, Borresen AL, Kaern J, Ronningen KS, Thorsby E. 1992. HLA antigens and cervical cancer. Nature 356:23
59. Henke RP, Guerin-Reverchon I, Milde-Longosch K, Strömme-Koppang H, Löning T. 1989. In situ detection of human papillomavirus types 13 and 32 in focal epithelial hyperplasia of the oral mucosa. J. Oral Pathol. Med. 18:419-21
60. Higgins CD, Uzelin DM, Phillips GE, McEnvoy P, Marin R, Burrell CJ. 1992. Transcription patterns of human papillomavirus type 16 in genital intraepithelial neoplasia: evidence for promoter usage within the E7 open reading frame during epithelial differentiation. J. Gen. Virol. 73:2047-57
61. Howley PM. 1991. Role of humanpapillomaviruses in human cancer. Cancer Res. 51:5019-22
62. Hurlin PJ, Kaur P, Smith P, Perez-Reyes N, Blanton RA, McDougall JK. 1991. Progression of human papillomavirus type 18 immortalized human keratinocytes to a malignant phenotype. Proc. Natl. Acad. Sci. USA 88:570-74
63. Iftner T, Oft M, Böhm S, Wilczynski SP, Pfister H. 1992. Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium. J. Virol. 66:4639-46
64. Jablonsku S, Fabjanska L, Formas I. 1966. On the viral aetiology of epidermodysplasia verruciformis. Dermatologica 132:369
65. Jablonska S, Majewski S. 1994. Epidermodysplasia verruciformis: immunological and clinical aspects. Curr. Top. Microbiol. Immunol. 86:157-75
66. Jablonska S, Milewski B. 1957. Kenntnis der Epidermodysplasia verruciformis. Dermatologica 115:1-22
67. Jürgensmeier JM, Schmitt CP, Viesel E, Höfler P, Bauer G. 1994. TGFβ treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis. Cancer Res. 54:393-98
68. Kahn T, Scwarz E, zur Hausen H. 1986. Molecular cloning and characterization of the DNA of a new human papillomavirus (HPV 30) from a laryngeal carcinoma. Int. J. Cancer 37:61-65
69. Kashima HK, Kutcher M, Kessis T, Levin LS, de Villiers E-M, Shah K. 1990. Human papillomavirus in squamous cell carcinoma, leukoplakia, lichen planus, and clinically normal epithelium of the oral cavity. Ann. Otol. Rhinol. Laryngol. 99:55-61
70. Kemp CJ, Donehower LA, Bradley A, Balmain A. 1993. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74:813-22
71. Kessis TD, Slebos RJ, Nelson WG, Kastan MB, Plunkett BS, et al. 1993. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc. Natl. Acad. Sci. USA 90:3988-92
72. Kiviat NB, Critschlow CW, Holmes KK, Kuypers J, Sayer J, et al. 1993. Association of anal dysplasia and human papillomavirus with immunosuppression and HIV infection among homosexual men. AIDS 7:43-49
73. Lewandowsky T, Lutz W. 1922. Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis). Arch. Dermatol. Syphilol. 141:193-203
74. Ley C, Bauer HM, Reingold A, Schiffman MH, Chambers C, et al. 1991. Determinants of genital human papillomavirus infection in young women. J. Natl. Cancer Inst. 83:997-1003
75. Lutz W. 1946. A propos de Lépidermodysplasie verruciforme. Dermatologica 92:30-43
76. McDougall JK. 1994. Immortalization and transformation of human cells by human papillomavirus. Curr. Top. Microbiol. Immunol. 86:101-19
77. Meijer CJLM, van den Brule AJC, Snijders PJF, Heimerhorst T, Kenemans P, Walboomers JMM. 1992. Detection of human papillomavirus in cervical scrapes by the polymerase chain reaction in relation to cytology: possible implications for cervical cancer screening. In The Epidemiology of Cervical Cancer and Human Papillomavirus, ed. N Munoz, FX Bosch, KV Shah, A Meheus, pp. 271-81. Lyon: Int. Agency Res. Cancer
78. Morrison EAB, Ho GYF, Vermund SH, Goldberg FI, Kadish AS, et al. 1991. Human papillomavirus infection and other risk factors for cervical neoplasia: a case-control study. Int. J. Cancer 49:6-13
79. Murray RF, Hobbs J, Payne B. 1971. Possible clonal origin of common warts (verruca vulgaris). Nature 232:51-52
80. Niedobitek G, Pitteroff S, Herbst H, Shepherd P, Finn T, et al. 1990. Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil. J. Clin. Pathol. 43:918-21
81. Nuovo GJ, Delvenne P, MacConnell P, Chalas E, Neto C, Mann WJ. 1991. Correlation of histology and detection of human papillomavirus DNA in vulvar cancers. Gynecol. Oncol. 43:275-80
82. Obalek S, Favre M, Szymanczuk J, Misiwiecz J, Jablonska S, Orth G. 1992. Human papillomavirus (HPV) types specific of epidermodysplasia verruciformis induced by HPV 3 or HPV 3-related types in immunosuppressed patients. J. Invest. Dermatol. 98:936-41
83. Ogura H, Watanabe S, Fukushima K, Masuda Y, Fujiwara T, Yabe Y. 1991. Presence of human papillomavirus type 18 DNA in a pharyngeal and a laryngeal carcinoma. Jpn. J. Cancer Res. 82:1184-86
84. Orth G, Favre M, Croissant O. 1977. Characterization of a new type of human papillomavirus that causes skin warts. J. Virol. 24:108-20
85. cdc2 and cyclin A levels by SV-40 large T antigen. Oncogene 8:2987-93
86. Parkin DM, Pisani P, Ferlay J. 1993. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int. J. Cancer 54:594-606
87. Pecoraro G, Lee M, Morgan D, Defendi V. 1991. Evolution of in vitro transformation and tumorigenesis of HPV 16 and HPV 18 immortalized primary cervical epithelial cells. Am. J. Pathol. 138:1-8
88. Pei XF, Meck JM, Greenhalgh D, Schlegel R. 1993. Cotransfection of HPV-18 and v-fos DNA induces tumorigenicity of primary human keratinocytes. Virology 196:855-60
89. Pereira-Smith OM, Smith JR. 1981. Expression of SV40 antigen in finite lifespan hybrids of normal and SV40-transformed fibroblasts. Somatic Cell Genet. 7:411-21
90. Pereira-Smith OM, Smith JR. 1988. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc. Natl. Acad. Sci. USA 85:6042-46
91. Pfister H, zur Hausen H. 1978. Seroepidemiological studies of human papilloma virus (HPV-1) infections. Int. J. Cancer 21:161-65
92. Pirisi L, Yasumoto S, Fellery M, Doninger JK, DiPaolo JA. 1987. Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol. 61:1061-66
93. Praetorius-Clausen F. 1973. Geographical aspects of oral epithelial hyperplasia. Pathol. Microbiol. 39:204-13
94. Premoli-De-Percoco G, Cistemas, Ramírez JP, Galindo I. 1993. Focal epithelial hyperplasia: human-papillomavirus-induced disease with a genetic predisposition in a Venezuelan family. Hum. Genet. 91:386-88
95. Rigoni-Stern D. 1842. Fatti statistici relativialle malatia cancerose. G. Serv. Prog. Pathol. Therap. 2:507-17
96. Rösl F, Lengert M, Albrecht J, Kleine K, Zawatzky R, et al. 1994. Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids. J. Virol. 68:2142-50
97. Rous P, Beard JW. 1934. Carcinomatous changes in virus-induced papillomas of the skin of the rabbit. Proc. Soc. Exp. Biol. Med. 32:578-80
98. Shamanin V, Delius H, de Villiers E-M. 1994. Development of a broad spectrum PCR assay for papillomaviruses and its application in screening lung cancer biopsies. J. Gen. Virol. In press
99. Scheffner M, Romanczuk H, Munger K, Huibregtse JM, Mietz JA, Howley PM. 1994. Functions of human papillomavirus proteins. Curr. Top. Microbiol. Immunol. 86:83-99
100. Scheurlen W, Stremlau A, Gissmann L, Höhn D, Zenner HP, zur Hausen H. 1986. Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma. Int. J. Cancer 38:671-76
101. Schiffman MH. 1994. Epidemiology of cervical human papillomavirus infections. Curr. Top. Microbiol. Immunol. 86:56-81
102. Schlehofer JR, Gissmann L, Matz B, zur Hausen H. 1983. Herpes simplex virus-induced amplification of SV40 sequences in transformed Chinese hamster embryo cells. Int. J. Cancer 32:99-103
103. Schlehofer JR, zur Hausen H. 1982. Induction of mutations within the host cell genome by partially inactivated herpes simplex virus type 1. Virology 122:471-75
104. Smits PHM, Smits HL, Minnaar R, Hemmings BA, Mayer-Jaekel RE, et al. 1992. The trans-activation of the HPV 16 long control region in human cells with a deletion in the short arm of chromosome 11 is mediated by the 55kDa regulatory subunit of protein phosphatase 2A. EMBO J. 11:4601-6
105. Snijders PJF, Meijer CJLM, van den Brule AJC, Walboomers JMM. 1994. Papillomaviruses and cancer of the upper digestive and respiratory tracts. Curr. Top. Microbiol. Immunol. 86:177-98
106. Soneira A, Fonseca N. 1964. Sobre una lesion de la mucosa oral en los ninos de la Mision los Angeles del Tokuko. Venezela Odont. 29:109
107. Stoler MH, Rhodes CR, Whitbeck A, Wolinsky SM, Chow LT, Broker TR. 1992. Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Hum. Pathol. 23:117-28
108. Strauss MJ, Shaw EW, Bunting H, Melnick JL. 1949. "Crystalline" virus-like particles from skin papillomas characterized by intranuclear inclusion bodies. Proc. Soc. Exp. Biol. Med. 72:46
109. Stremlau A, Gissmann L, Ikenberg H., Stark M, Bannasch P, zur Hausen H. 1985. Human papilloma virus type 16 related DNA in an anaplastic carcinoma of the lung. Cancer 55:1737-40
110. Ter Meulen J, Schweigler AC, Eberhardt HC, Luande J, Mgaya HN, et al. 1993. Sequence variation in the E7 gene of human papillomavirus type 18 in tumor and non-tumor patients and antibody response to a conserved seroactive epitope. Int. J. Cancer 53:257-59
111. Tindle RW, Frazer IH. 1994. Immune response to human papillomaviruses and the prospects for human papillomavirus-specific immunization. Curr. Top. Microbiol. Immunol. 86:218-52
112. van den Brule AJ, Walboomers JMM, du Maine M, Kenemans P, Meijer CJLM. 1991. Difference in prevalence of human papillomavirus genotypes in cytomorphologically normal cervical smears is associated with a history of cervical intraepithelial neoplasia. Int. J. Cancer 48:404-8
113. van Wyk CW, Staz J, Farmon AG. 1977. Focal epithelial hyperplasia in a group of South Africans. Its ultrastructural features. J. Oral Pathol. 6:14-24
114. Wank R, Schendel DJ, Thomssen C. 1992. HLA antigens and cervical carcinoma. Nature 356:22-23
115. Wank R, Thomssen C. 1991. High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3. Nature 352:723-25
116. Whitaker NJ, Kidston EL, Reddel RR. 1992. Finite lifespan of hybrids formed by fusion of different simian virus 40-immortalized human cell lines. J. Virol. 66:1202-6
117. Wu T-C, Trujillo JM, Kashima HK, Mounts P. 1993. Association of human papillomavirus with nasal neoplasia. Lancet 341:522-24
118. zur Hausen H. 1976. Condylomata acuminata and human genital cancer. Cancer Res. 36:794
119. zur Hausen H. 1986. Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events. Lancet 2:1370-72
120. zur Hausen H. 1989. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Res. 49:4677-81
121. zur Hausen H. 1991. Papillomavirus/host cell interactions in the pathogenesis of anogenital cancer. In Origins of Human Cancer: A Comprehensive Review, ed. J Brugge, T Curran, E Harlow, F McCormick, pp. 685-705. Cold Spring Harbor, NY: Cold Spring Harbor Lab.
122. zur Hausen H. 1994. Molecular pathogenesis of cancer of the cervix and its causation by specific HPV types. Curr. Top. Microbiol. Immunol. 86:131-56
123. zur Hausen H, Meinhof W, Schreiber W, Bornkamm GW. 1974. Attempts to detect virus-specific DNA sequences in human tumors: nucleic acid hybridizations with complementary RNA of human wart virus. Int. J. Cancer 13:650-56