Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptormediated phosphoinositide (PI) turnover by clozapine in the rat: A comparison to other antipsychotics

Neuroscience Letters

Volumn 181, Issue 1-2, 1994, Pages 65-68

  Canton, Hervé ^a   Verrièle, Laurence ^a   Millan, Mark J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

5 HT2A; 5 HT2C; Antipsychotic; Clozapine; Cortex; Haloperidol; Phosphoinositide; Serotonin

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; FLUPHENAZINE; HALOPERIDOL; NEUROLEPTIC AGENT; RACLOPRIDE; RECEPTOR SUBTYPE; RISPERIDONE; RITANSERIN; SEROTONIN 2 RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN ANTAGONIST; SPIPERONE; SULPIRIDE; THIORIDAZINE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; FEMALE; MALE; NEWBORN; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT;

ANIMAL; ANTIPSYCHOTIC AGENTS; BINDING, COMPETITIVE; CHOROID PLEXUS; CLOZAPINE; COMPARATIVE STUDY; FEMALE; FRONTAL LOBE; MALE; PHOSPHATIDYLINOSITOLS; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN;

EID: 0027985591     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(94)90561-4     Document Type: Article

References (33)

1. Do central antiadrenergic actions contribute to the atypical properties of clozapine?
2. 2C receptors reveal novel inverse agonist activity of receptor ligands
3. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
4. 1C sites
5. Pharmacological characterization of serotonin-stimulated PI turnover in brain regions of the immature rat
6. 2 binding site in rat cerebral cortex but not in subcortical regions
7. A unique serotonin receptor in choriod plexus is linked to phosphatidylinositol turnover
8. Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins
9. Mechanisms of action of atypical antipsychotic drugs
10. Clozapine blocks disruptive and discriminative stimulus effects of quipazine
11. Serotonin receptors: clinical implications
12. Serotonin receptors and their ligands: a lack of selective agents
13. 2 antagonist, in electrophysiological tests predictive of antipsychotic activity
14. Chronic clozapine treatment down-regulates serotonin 5-HT-1C receptors in rat brain
15. 2 receptors
16. 5-HT receptors: subtypes and second messengers
17. 2 recognition sites
18. A proposed new nomenclature for 5-HT receptors
19. 2 antagonistic properties
20. Clozapine for the treatment-resistant schizophrenic
21. 1C receptors
22. 1C receptor antagonists
23. 1A receptors
24. Receptor-binding properties in vitro and in vivo of ritanserin
25. i values
26. Effects of antipsychotic drugs on serotonin receptors
27. 1C/2 antagonists as therapeutic agents
28. 1C/2 receptors
29. 1C receptor is a prominent serotonin receptor subtype in the central nervous system
30. Inability of an opioid antagonist lacking negative intrinsic activity to induce opioid receptor upregulation in vivo
31. 1C receptors
32. Reverse intrinsic activity of antagonists on G protein-coupled receptors.
33. 4 receptor with high affinity for the antipsychotic clozapine