Contribution of endogenous generation of endothelin-1 to basal vascular tone

The Lancet

Volumn 344, Issue 8926, 1994, Pages 852-854

  Haynes, W G ^a   Webb, D J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; PHOSPHORAMIDON; VASODILATOR AGENT;

ADULT; ARTICLE; BLOOD VESSEL TONE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; VASODILATATION;

EID: 0027983753     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(94)92827-4     Document Type: Article

References (15)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. Phosphoramidon inhibits the generation of endothelin-1 from exogenously applied big endothelin-1 in cultured vascular endothelial cells and smooth muscle cells
3. Phosphoramidon blocks the pressor activity of big endothelin [1-39] and lowers blood pressure in spontaneously hypertensive rats
4. The endothelin family of peptides: local hormones with diverse roles in health and disease?
5. Endothelins come of age
6. Local inhibition of converting enzyme and vascular responses to angiotensin and bradykinin in the human forearm
7. Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor
8. Some practical problems in medical research: serial measurements.
9. Is big endothelin converted to endothelin-1 in circulating blood?
10. Specific inhibitors of endopeptidase 2411 inhibit the metabolism of atrial peptides in vitro and in vivo
11. A receptor subtype in the anaethetised rat: effect of BQ-123 on systemic haemodynamic responses
12. A) receptor antagonist in conscious rats
13. Antihypertensive effect of a newly synthetised endothelin antagonist, BQ-123, in a genetic hypertensive model
14. A receptor activation
15. Pathophysiological role of endothelin revealed by the first orally endothelin receptor antagonist