Postmortem changes in the levels and localization of microtubule‐associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus

Hippocampus

Volumn 4, Issue 2, 1994, Pages 210-225

  Schwab, Claudia ^a   Bondada, Vimala ^a   Sparks, D Larry ^a,b   Cahan, Leslie D ^b   Geddes, James W ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c KAISER PERMANENTE   (United States)

Author keywords

cytoskeleton; immunoblots; immunohistochemistry

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 2; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DEATH; ELECTROPHORETIC MOBILITY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NERVE DEGENERATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; SUBICULUM;

ADOLESCENT; ADULT; ANIMAL; COMPARATIVE STUDY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HIPPOCAMPUS; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGE; POSTMORTEM CHANGES; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TAU PROTEINS;

EID: 0027981303     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.450040212     Document Type: Article

References (47)

1. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
2. Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer's disease
3. Hippocampal region
4. Light and electron microscopic studies of the distribution of microtubule‐associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons
5. The switch of tau protein to an Alzheimer‐like state includes the phosphorylation of two serine‐proline motifs upstream of the microtubule binding region
6. The distribution of tau in the mammalian central nervous system
7. Microtubule‐associated protein 1B: identification of a major component of the neuronal cytoskeleton
8. Microheterogeneity of microtubule‐associated tau proteins is due to differences in phosphorylation
9. Distribution of microtubule‐associated protein 2 in the nervous system of the rat studied by immunofluorescence
10. Calpain‐mediated proteolysis of microtubule associated proteins MAP1B and MAP2 in developing brain
11. Microtubule‐associated proteins MAP5 and MAP1x: closely related components of the neuronal cytoskeleton with different cytoplasmic distributions in the developing brain
12. Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease
13. Aberrant localization of MAP5 immunoreactivity in the hippocampal formation in Alzheimer's disease
14. Calcium and the aging nervous system
15. Abnormal phosphorylation of the microtubule‐associated protein tau (tau) in Alzheimer cytoskeletal pathology
16. Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease
17. Differences in the cellular distributions of two microtubule‐associated proteins, MAP1 and MAP2, in rat brain
18. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease
19. Alzheimer's disease: from cytoskeletal protein pathology to neuronal degeneration
20. Tau epitopes are incorporated into a range of lesions in Alzheimer's disease
21. Proteolysis of tau by calpain
22. Degradation of microtubule‐associated protein 2 and brain spectrin by calpain: a comparative study
23. Selective neuronal vulnerability following transient global cerebral ischemia in the rat and gerbil
24. The role of calcium regulation in brain aging: reexamination of a hypothesis
25. Microtubule‐associated protein 2 as a sensitive marker for cerebral ischemic damage–immunohistochemical investigation of dendritic damage
26. Tau protein and Alzheimer's disease
27. Epitopes that span the tau molecule are shared with paired helical filaments
28. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. The disordered neuronal cytoskeleton in Alzheimer's disease
31. Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and calcium influx in cultured hippocampal neurons
32. Possible involvement of calcium and inositol phospholipid signaling pathways in neurofibrillary degeneration
33. β‐amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitoxicity
34. Microtubular reorganization and dendritic growth response in Alzheimer's disease
35. Phosphorylation determines two distinct species of Tau in the central nervous system
36. 2+)‐calmodulin regulated effectors of microtubule stability in neuronal tissues
37. Sequestration of tubulin in neurons in Alzheimer's disease
38. MAP 5: a novel brain microtubule‐associated protein under strong developmental regulation
39. Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus
40. Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease
41. Postmortem stability of dopamine, glutamate decarboxylase and choline acetyltransferase in the mouse brain under conditions simulating the handling of human autopsy material
42. Selective expression of epitopes in multiphosphorylation repeats of the high and middle molecular weight neurofilament proteins in Alzheimer neurofibrillary tangles
43. Distribution of phosphate‐independent MAP2 epitopes revealed with monoclonal antibodies in microwave‐dentured human nervous system tissues
44. Distribution of tau proteins in the normal human central and peripheral nervous system
45. Neuronal microtubule‐associated proteins in the embryonic avian spinal cord
46. The sequential appearence of low‐and high‐molecular weight forms of MAP2 in the developing cerebellum
47. Differential vulnerability of microtubule components in cerebral ischemia