Suppression of the constitutive microsomal cytochrome P450 2C11 in male rat liver during dietary vitamin A deficiency

Biochemical Pharmacology

Volumn 48, Issue 6, 1994, Pages 1305-1309

  Martini, Robert ^a   Murray, Michael ^a  

^a WESTMEAD HOSPITAL   (Australia)

Author keywords

hepatic oxidoreductases; micronutrient regulation; microsomal steroid hydroxylation; retinoids

Indexed keywords

ALPHA TOCOPHEROL; ANDROSTENEDIONE; CYTOCHROME P450 ISOENZYME; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; HYDROXYLATION; IMMUNOCHEMISTRY; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINOL DEFICIENCY; STEROID METABOLISM; TISSUE LEVEL;

ANDROSTENEDIONE; ANIMAL; CYTOCHROME P-450 ENZYME SYSTEM; DIET; DOWN-REGULATION; GENE EXPRESSION; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; STEROID HYDROXYLASES; SUPPORT, NON-U.S. GOV'T; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 0027981260     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90170-8     Document Type: Article

References (28)

1. Enzymatic conversion of all-trans-β-carotene to retinal by a cytosolic enzyme from rabbit and rat intestinal mucosa
2. Vitamin A metabolism: new perspectives on absorption, transport and storage
3. Interactions of hepatic cytochromes P450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P450 enzyme expression
4. Growth hormone (GH) regulation of cytochrome P450 IIC12, insulin-like growth factor-I (IGF-I), and GH receptor messenger RNA expression in primary rat hepatocytes: A hormonal interplay with insulin, IGF-I, and thyroid hormone
5. Enzyme induction in the cytochrome P450 system
6. Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes
7. Downregulation of the male-specific hepatic micro-somal steroid 16α-hydroxylase, cytochrome P450 UT-A, in rats with portal bypass: relevance to estradiol accumulation and impaired drug metabolism in hepatic cirrhosis
8. Impaired expression of microsomal cytochrome P450 2C11 in choline-deficient rat liver during the development of cirrhosis
9. Role of nutrition in the drug-metabolizing enzyme system
10. Increased expression of cytochrome P450 IIIA2 in male rat liver after dietary vitamin A supplementation
11. Dietary effects on cytochrome P450, xenobiotic metabolism, and toxicity
12. The differential effects of chemical carcinogens on vitamin A status and on microsomal drug metabolism in normal and vitamin A-deficient rats
13. Hepatic cytochrome P-450-dependent metabolism and enzymatic conjugation of foreign compounds in vitamin A-deficient rats
14. Vitamin A levels in regenerating rat liver. Effects on microsomal drug metabolism
15. Effects of dihydrosafrole on cytochrome P450 and drug oxidation in hepatic microsomes from control and induced rats
16. Participation of P450 3A enzymes in rat hepatic microsomal retinoic acid 4-hydroxylation
17. Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from pheno-barbital-induced rat liver
18. A time-course investigation of vitamin A levels and drug metabolizing enzyme activities in rats following a single treatment with prototypic polychlorinated biphenyls and DDT
19. Drug metabolism in cirrhosis: selective changes in cytochrome P-450 isozymes in the choline-deficient rat model
20. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
21. Protein measurement with the Folin phenol reagent
22. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
23. Regulation of retinol-binding protein metabolism by vitamin A status in the rat
24. Vitamin A status and hepatic drug metabolism in the rat
25. Regioselective progesterone hydroxylation catalyzed by eleven rat hepatic cytochrome P450 isozymes
26. Effects of retinoic acid on hepatic cytochrome P-450 dependent enzymes in rats under different vitamin A status
27. Evidence of a role for retinoic acid (vitamin A acid) in the maintenance of testosterone production in male rats
28. Effects of high dietary vitamin A on drug-metabolizing enzyme activities in guinea pig and rabbit.