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Volumn 30, Issue 8, 1994, Pages 1138-1144

Inhibiting intracellular signalling as a strategy for cancer chemoprevention

Author keywords

chemoprevention; growth factors; intracellular signalling; oncogenes

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; AMLODIPINE; ANTINEOPLASTIC AGENT; BRYOSTATIN 1; CARBACHOL; DILTIAZEM; EDELFOSINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE INHIBITOR; RETINOIC ACID; RETINOID; TAMOXIFEN; VERAPAMIL;

EID: 0027981240     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(94)90473-1     Document Type: Article
Times cited : (18)

References (128)
  • 2
  • 4
    • 0028069064 scopus 로고
    • Signalling pathways as targets for anticancer drug development.
    • in press
    • (1994) Pharmacol Ther
    • Powis1
  • 9
  • 11
    • 0026661584 scopus 로고
    • Control of transcription factors by signal transduction pathways: the beginning of the end
    • (1992) Trends Biochem Sci , vol.17 , pp. 418-422
    • Karin1    Smeal2
  • 12
    • 84908825888 scopus 로고
    • Phospholipases C and D in mitogenic signal transduction
    • (1992) Science , vol.119 , pp. 14-38
    • Cook1    Wakelam2
  • 13
    • 84908864413 scopus 로고
    • EGF increases sn-1,2-diglyceride levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol lipid hydrolysis
    • (1992) Biochem J , vol.281 , pp. 597-600
    • Cook1    Wakelam2
  • 16
    • 0019974977 scopus 로고
    • Platelet-derived growth factor stimulates tyrosine specific protein kinase activity in Swiss mouse 3T3 cell membranes
    • 3rd ed.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 4303-4307
    • Nishimura1    Huang2    Deuel3
  • 17
    • 0026451688 scopus 로고
    • Protein with SH2 domains: transducers in the tyrosine kinase signalling pathway
    • (1992) Cell Growth Differ , vol.3 , pp. 73-80
    • Margolis1
  • 19
    • 0026340995 scopus 로고
    • Phosphoinositide 3-kinase: a new effector in signal transduction?
    • (1991) Cell Signal , vol.3 , pp. 501-507
    • Downes1    Carter2
  • 22
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday1    Downward2
  • 23
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • (1992) Science , vol.258 , pp. 478-480
    • Crews1    Alessandrini2    Erikson3
  • 24
    • 0026585231 scopus 로고
    • MAP kinase by any other name smells just as sweet
    • (1992) Cell , vol.68 , pp. 3-6
    • Thomas1
  • 27
    • 0026523559 scopus 로고
    • ras mediates nerve growth factor receptor modulation of three signal transducing protein kinases: Map kinase, Raf-1 and RSK
    • (1992) Cell , vol.68 , pp. 1041-1048
    • Wood1    Sarnecki2    Roberts3    Blenis4
  • 28
    • 0027322679 scopus 로고
    • Protein kinase C isoenzymes: divergence in signal transduction?
    • (1993) Biochem J , vol.291 , pp. 329-343
    • Hug1    Sarre2
  • 29
    • 0025871767 scopus 로고
    • Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase
    • (1991) J Biol Chem , vol.266 , pp. 15277-15285
    • Alvarez1    Northwood2    Gonzalez3
  • 31
    • 0026067787 scopus 로고
    • Selective translocation of β protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells
    • (1991) J Biol Chem , vol.266 , pp. 28-33
    • Hocevar1    Fields2
  • 33
    • 0026049244 scopus 로고
    • c-myc gene induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation
    • (1991) Cancer Res , vol.51 , pp. 5514-5519
    • Barr1    Mabry2    Nelkin3    Tyrler4    May5    Baylin6
  • 35
    • 0024284828 scopus 로고
    • Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
    • (1988) Cell , vol.52 , pp. 343-354
    • Housey1    Johnson2    Hsiao3
  • 36
    • 0024284812 scopus 로고
    • Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-1 cDNA
    • (1988) Cell , vol.52 , pp. 447-458
    • Persons1    Wilkison2    Bell3    Finn4
  • 37
    • 0027418816 scopus 로고
    • Overexpression of protein kinase C-δ and -ϵ in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
    • (1993) J Biol Chem , vol.268 , pp. 6090-6096
    • Mischak1    Goodnight2    Kolch3
  • 38
    • 0027271956 scopus 로고
    • The role of tamoxifin in the prevention and treatment of benign and malignant breast lesions: a chemopreventive
    • (1993) Int Surg , vol.78 , pp. 176-182
    • Leis1
  • 39
    • 0025376021 scopus 로고
    • Establishment and characterization of UM-EC-2, a tamoxifen-sensitive, estrogen receptor-negative human endometrial carcinoma cell line
    • (1990) Gynecol Oncol , vol.37 , pp. 188-199
    • Grenman1    Worsham2    Van Dyke3
  • 42
  • 44
    • 0026786645 scopus 로고
    • Tamoxifen supresses tumor promoter-induced hydrogen peroxide formation by human neutrophils
    • (1992) Cancer Res , vol.52 , pp. 4872-4969
    • Lim1    Frenkel2    Troll3
  • 45
    • 0026706541 scopus 로고
    • The roles of calmodulin and protein kinase C in histamine secretion from mast cells
    • (1992) Agents Act , vol.36 , pp. 183-191
    • Chakravarty1
  • 46
    • 0026697265 scopus 로고
    • Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells
    • (1992) Mol Cell Endocrin , vol.85 , pp. 215-225
    • Patel1    Schrey2
  • 48
    • 0020608781 scopus 로고
    • Characterization of cystolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells
    • (1983) J Biol Chem , vol.158 , pp. 9178-9183
    • Kraft1    Anderson2
  • 49
    • 0024392010 scopus 로고
    • Induction of protein Kinase C in mouse melanoma cells by retinoic acid
    • (1989) Cancer Res , vol.49 , pp. 4483-4487
    • Niles1    Loewy2
  • 50
    • 0023833753 scopus 로고
    • Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid
    • (1988) J Biol Chem , vol.263 , pp. 3402-3410
    • Makowske1    Ballester2    Cayres3    Rosen4
  • 55
    • 0021995182 scopus 로고
    • Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme
    • (1985) J Neurochem , vol.44 , pp. 175-182
    • Ghalayini1    Eichberg2
  • 57
    • 0027518643 scopus 로고
    • Regression of oral leukoplakia with alpha tocopherol: a community clinical oncology program chemoprevention study
    • (1993) J Natl Cancer Inst , vol.85 , pp. 44-47
    • Benner1    Winn2    Lippman3
  • 59
    • 0027286003 scopus 로고
    • d-α-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells
    • (1993) FEBS Letters , vol.322 , pp. 307-310
    • Ozer1    Palozza2    Boscoboinik3    Azzi4
  • 61
    • 0000503498 scopus 로고
    • Ether lipids in experimental cancer chemotherapy
    • J.A. Hickman, T.R. Tritton, Blackwell Sci, Oxford
    • (1993) Cancer Chemotherapy , pp. 146-177
    • Daniel1
  • 63
    • 0025296440 scopus 로고
    • Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues
    • (1990) Cancer Res , vol.50 , pp. 3025-3031
    • Zheng1    Oishi2    Shoji3
  • 64
    • 0020645583 scopus 로고
    • 2+ dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid
    • (1983) Cancer Res , vol.43 , pp. 2955-2961
    • Helfman1    Barnes2    Kinkade3    Vogler4    Shoji5    Kuo6
  • 65
    • 0025233636 scopus 로고
    • Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C
    • (1990) J Med Chem , vol.33 , pp. 985-991
    • Marasco1    Piantadosi2    Ishaq3
  • 66
    • 0024272358 scopus 로고
    • Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells
    • (1988) Cancer Res , vol.48 , pp. 6669-6673
    • Shoji1    Raynor2    Berdel3    Vogler4    Kuo5
  • 68
  • 69
    • 0025169805 scopus 로고
    • Inhibition of Na, K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid
    • (1990) J Biol Chem , vol.265 , pp. 70-75
    • Oishi1    Zheng2    Kuo3
  • 75
    • 0023518618 scopus 로고
    • Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids
    • (1987) Lipids , vol.77 , pp. 935-942
    • Berger1    Schmähl2
  • 76
    • 0026561844 scopus 로고
    • Suppression of malignancy targeting cyclic AMP signal transducing proteins
    • (1992) Biochem Soc Trans , vol.20 , pp. 425-430
    • Cho-Chung1
  • 77
    • 0019308712 scopus 로고
    • Retinoic acid increases cyclic AMP dependent protein kinase activity in murine melanoma cells
    • (1980) J Biol Chem , vol.255 , pp. 5999-6002
    • Ludwig1    Loewy2    Niles3
  • 78
    • 84908861680 scopus 로고    scopus 로고
    • Abou-Issa H, Duruibe V. In vitro and in vivo inhibition of breast cancer growth by retinoids via cyclic AMP-dependent protein kinase. FASEB J 2, A859.
  • 79
    • 0020957654 scopus 로고
    • Role of retinoids in differentiation and carcinogenesis
    • (1983) Cancer Res , vol.43 , pp. 3034-3040
    • Sporn1    Roberts2
  • 80
    • 0026591799 scopus 로고
    • Tyrosine-phosphorylated proteins: mediators of signal transduction from the tyrosine kinases
    • (1992) Biochim Biophys Acta , vol.1134 , pp. 113-127
    • Glenney1
  • 81
    • 0026578427 scopus 로고
    • Protein-tyrosine kinase inhibitors
    • (1992) Drugs Future , vol.17 , pp. 119-131
    • Burke1
  • 82
    • 0026021498 scopus 로고
    • Combination of blocking agents and suppressing agents in cancer prevention
    • (1991) Carcinogenesis , vol.12 , pp. 365-367
    • Ip1    Ganther2
  • 85
    • 0026624967 scopus 로고
    • Inhibition of cancer cell growth by calcium channel antagonists in the athymic mouse
    • (1992) Cancer Res , vol.52 , pp. 2413-2418
    • Taylor1    Simpson2
  • 88
    • 0026740712 scopus 로고
    • In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates
    • (1992) Cancer Res , vol.52 , pp. 3208-3212
    • Kohn1    Sandeen2    Liotta3
  • 89
    • 0025772585 scopus 로고
    • The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 967-971
    • Felder1    Ma2    Liotta3    Kohn4
  • 90
    • 0025912644 scopus 로고
    • The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651, 582
    • (1991) J Biol Chem , vol.266 , pp. 10136-10142
    • Hupe1    Boltz2    Cohen3
  • 91
    • 0025043173 scopus 로고
    • Anti-proliferative activity of L-651, 582 correlates with calcium-mediated regulation of nucleotide metabolism at phosphoribosyl pyrophosphate synthetase
    • (1990) J Cell Physiol , vol.144 , pp. 457-466
    • Hupe1    Behrens2    Boltz3
  • 92
    • 0028009848 scopus 로고
    • Calcium-mediated signal transduction: biology, biochemistry and therapy
    • (1994) Cancer Metast Rev , vol.13 , pp. 31-44
    • Cole1    Kohn2
  • 95
    • 0023129529 scopus 로고
    • Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line
    • (1987) Cancer Res , vol.47 , pp. 70-74
    • Greenberg1    Carpenter2    Messing3
  • 97
    • 0028144440 scopus 로고
    • Effect of tamoxifen on carbachol-triggered intracellular calcium responses in chicken granulosa cells
    • (1994) Cancer Res , vol.54 , pp. 69-74
    • Morley1    Whitfield2
  • 98
    • 0025193824 scopus 로고
    • 2+-dependent binding of tamoxifen to calmodulin isolated from bovine brain
    • (1990) Cancer Res , vol.50 , pp. 2753-2758
    • Lopes1    Vale2    Carvalho3
  • 101
  • 103
    • 0021141476 scopus 로고
    • A comparison of two doses of tamoxifen (Nolvadex) in postmentrual women with advanced breast cancer: 10 mg bd versus 20 mg bd
    • (1984) Br J Cancer , vol.50 , pp. 199-205
    • Bratherton1    Brown2    Buchanan3
  • 105
    • 0025877861 scopus 로고
    • Ras C-terminal processing enzymes—new drug targets?
    • (1991) Cell , vol.65 , pp. 1-4
    • Gibbs1
  • 107
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21–26-kDa proteins by the anticarcinogen d-limonene and its metabolites
    • (1991) J Biol Chem , vol.266 , pp. 17679-17685
    • Crowell1    Chang2    Ren3    Elson4    Gould5
  • 111
    • 0040208441 scopus 로고
    • 2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bom-besin and vasopressin
    • (1988) EMBO J , vol.9 , pp. 2741-2747
    • Nånberg1    Rozengurt2
  • 114
    • 84908848599 scopus 로고
    • Oncogenic forms of the neu/HER2 tyrosine kinqase are permanently coupled to phospholipase C-γ
    • (1991) EMBO J , vol.10 , pp. 20778-22086
    • Peles1    Levy2    Or3    Ullrich4    Yarden5
  • 115
    • 0027211693 scopus 로고
    • Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
    • (1993) Cell , vol.73 , pp. 321-334
    • Valius1    Kazlauska2
  • 116
    • 0018651505 scopus 로고
    • Use of hepatic cell cultures to detect and evaluate the mechanism of action of toxic chemicals
    • (1979) Int Rev Exp Pathol , vol.20 , pp. 123-209
    • Grisham1
  • 118
    • 0005356220 scopus 로고
    • Increased phospholipase C(PLC)-γ, activity in human non-small cell lung (NSCLC) and renal cell (RCC) carcinomas correlates with elevated EGF receptor levels
    • 3rd ed.
    • (1992) Proc Am Assoc Cancer Res , vol.33 , pp. 89
    • Robertson1    Hurd2    Koch3    Arteaga4
  • 121
    • 0027530795 scopus 로고
    • Inhibition of phospholipase Cδ by hexadecylphosphorylcholine and lysophospholipids with antitumor activity
    • (1993) Biochem Pharmacol , vol.45 , pp. 493-497
    • Pawelczyk1    Lowenstein2
  • 126
    • 0026021294 scopus 로고
    • The differentiating agent, retinoic acid, causes an early inhibition of inositol lipid-specific phospholipase C activity in HL-60 cells
    • (1991) Cell Signal , vol.3 , pp. 11-23
    • Geny1    Cost2    Barreau3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.