1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2- phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Antimicrobial Agents and Chemotherapy

Volumn 38, Issue 10, 1994, Pages 2387-2391

  Bischofberger, N ^a   Hitchcock, M J M ^a   Chen, M S ^a   Barkhimer, D B ^a   Cundy, K C ^a   Kent, K M ^a   Lacy, S A ^a   Lee, W A ^a   Li, Z H ^a   Mendel, D B ^a   Smee, D F ^a   Smith, J L ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 HYDROXY 2 OXO 1,4,2 DIOXAPHOSPHORINAN 5 YL)METHYL]CYTOSINE; ACICLOVIR; CIDOFOVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG SAFETY; DRUG STABILITY; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN TISSUE; MAXIMUM ALLOWABLE CONCENTRATION; NEPHROTOXICITY; PRIORITY JOURNAL; VIRUS ENCEPHALITIS; VIRUS INFECTION;

EID: 0027980318     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.38.10.2387     Document Type: Article

References (0)