Evaluation of cold-adapted, reassortant influenza b virus vaccines in elderly and chronically iii adults

Journal of Infectious Diseases

Volumn 169, Issue 2, 1994, Pages 402-407

  Treanor, John ^a   Dumyati, Ghinwa ^a   O’brien, Diane ^a   Riley, Mary Ann ^a   Riley, Gregory ^a   Erb, Shirley ^a   Betts, Robert ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INACTIVATED VACCINE; INFLUENZA VACCINE; LIVE VACCINE;

AGED; ANTIBODY RESPONSE; ARTICLE; CHRONIC DISEASE; CLINICAL TRIAL; DRUG SAFETY; ELDERLY CARE; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INFLUENZA VACCINATION; INFLUENZA VIRUS B; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS INFECTION;

AGED; AGING; ANTIBODIES, VIRAL; CHRONIC DISEASE; COLD; DOUBLE-BLIND METHOD; HUMAN; INFLUENZA B VIRUS; INFLUENZA VACCINE; SUPPORT, U.S. GOV'T, P.H.S.; VACCINATION; VACCINES, ATTENUATED;

EID: 0027980199     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/169.2.402     Document Type: Article

References (15)

1. Barker WH. Excess pneumonia and influenza associated hospitalization during influenza epidemics in the United States, 1970-1978. Am J Public Health 1986:76:761-5.
2. Centers for Disease Control and Prevention. Prevention and control ofinfluenza: Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR 1992;41:1-17.
3. Johnson PR, Feldman S, Thompson JM, et al. Immunity to influenza A virus infection in young children: A comparison of natural infection, live cold-adapted vaccine, and inactivated vaccine. J Infect Dis 1986;154:121-7.
4. Maassab HF, DeBorde DC. Development and characterization of cold- adapted viruses for use as live virus vaccines. Vaccine 1985:3:335-69.
5. Keitel WA, Couch RB, Cate TR, et al. Cold-recombinant influenza B/Texas/1/84 virus vaccine: Attenuation, immunogenicity, and efficacy against homotypic challenge. J Infect Dis 1990;161:22-6.
6. Clements ML, Snyder MH, Sears SD, et al. Evaluation of the infectivity, immunogenicity, and efficacy of live cold-adapted influenza B/Ann Arbor/1/86 reassortant virus in adult volunteers. J Infect Dis 1990:161:869-77.
7. Edwards KM, King JC, Steinhoff MC, et al. Safety and immunogenicity of live attenuated cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in infants and children. J Infect Dis 1991; 163:740-5.
8. Anderson EL, Newman FK, Maassab HF, et al. Evaluation of a cold-adapted influenza B/Texas/84 reassortant virus (CRB-87) vaccine in young children. J Clin Microbiol 1992;30:2230-4.
9. Treanor JJ, Betts RF. Evaluation of live attenuated cold-adapted influenza B/Yamagata/16/88 reassortant virus vaccine in healthy adults. J Infect Dis 1993;168:455-9.
10. Frank AL, Puck J, Hughes BJ, et al. Microneutralization test for influenza A and B and parainfluenza I and 2 viruses that uses continuous cell lines and fresh serum enhancement. J Clin Microbiol 1980; 12:426-32.
11. Gorse GJ, Belshe RB, Munn NJ. Local and systemic antibody responses in high-risk adults given live attenuated and inactivated influenza A virus vaccines. J Clin Microbiol 1988;26:911-8.
12. Powers DC, Sears SD, Murphy BR, et al. Systemic and local antibody responses in elderly subjects given live or inactivated influenza A virus vaccines. J Clin Microbiol 1989;27:2666-71.
13. Powers DC, Fries LF, Murphy BR, et al. In elderly persons live attenuated influenza A virus vaccines do not offer an advantage over inactivated virus vaccine in inducing serum or secretory antibodies or local immunologic memory. J Clin Microbiol 1991;29:498-505.
14. Powers DC, Murphy BR, Fries L, et al. Reduced infectivity of cold- adapted influenza A H1N1 viruses in the elderly: Correlation with serum and local antibodies. J Am Geriatr Soc 1992;40:163-7.
15. Treanor JJ, Mattison HR, Dumyati G, et al. Protective efficacy of combined live intranasal and inactivated influenza A virus vaccines in the elderly. Ann Intern Med 1992;! 17:625-33.