Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes

Journal of Experimental Medicine

Volumn 179, Issue 3, 1994, Pages 921-930

  Gaugler, Béatrice ^a,b   Van Den Eynde, Benoit ^a,b   Van Der Bruggen, Pierre ^a,b   Romero, Pedro ^b,c   Gaforio, Jose Juan ^a,b,d   De Plaen, Etienne ^a,b   Lethé, Bernard ^a,b   Brasseur, Francis ^a,b   Boon, Thierry ^a,b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; BREAST CARCINOMA; CELL CLONE; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LUNG CARCINOMA; MELANOMA; MULTIGENE FAMILY; OPEN READING FRAME; PRIORITY JOURNAL; RNA ANALYSIS; SQUAMOUS CELL CARCINOMA;

EID: 0027980103     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.179.3.921     Document Type: Article

References (41)

1. Mukherji, B., and T. J. MacAlister. 1983. Clonal analysis of cytotoxic T cell response against human melanoma. J. Exp. Med. 158:240.
2. Knuth, A., B. Danowski, H.F. Oettgen, and L. Old. 1984. T-cell mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin-2-dependent T-cell cultures. Proc. Natl. Acad. Sci. USA. 81:3511.
3. Hérin, M., C. Lemoine, P. Weynants, F. Vessière, A. Van Pel, A. Knuth, R. Devos, and T. Boon. 1987. Production of stable cytolytic T-cell clones directed against autologous human melanoma. Int. J. Cancer. 39:390.
4. Topalian, S.L., D. Solomon, and S.A. Rosenberg. 1989. Tumor-specific cytolysis by lymphocytes infiltrating human melanomas. J. Immunol. 142:3714.
5. Van den Eynde, B., P. Hainaut, M. Hérin, A. Knuth, C. Lemoine, P. Weynants, P. van der Bruggen, R. Fauchet, and T. Boon. 1989. Presence on a human melanoma of multiple antigens recognized by autologous CTL. Int. J. Cancer. 44:634.
6. van der Bruggen, P., C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, B. Van den Eynde, A. Knuth, and T. Boon. 1991. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science (Wash. DC). 254:1643.
7. De Smet, C., C. Lurquin, P. van der Bruggen, E. De Plaen, F. Brasseur, and T. Boon. 1994. Sequence and pattern of expression of human gene MAGE-2, Immunogenetics. 39:121.
8. Traversari, C., P. van der Bruggen, I.F. Luescher, C. Lurquin, P. Chomez, A. Van Pel, E. De Plaen, A. Amar-Costesec, and T. Boon. 1992. A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E. J. Exp. Med. 176:1453.
9. Yang, S.Y., E. Milford, U. Hämmerling, and B. Dupont. 1989. Description of the reference panel of B-lymphoblastoid cell lines for factors of the HLA system: the B-cell line panel designed for the Tenth International Histocompatibility workshop. In Immunobiology of HLA. B. Dupont, editor. Springer-Verlag, New York. 11.
10. - mutation. Proc. Natl Acad. Sci. USA. 85:2274.
11. - transplantation antigen P91A. A peptide encoded by the mutated exon is recognized with Ld by cytolytic T cells. Cell. 58:293.
12. Seed, B., and A. Aruffo. 1987. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc. Natl. Acad. Sci. USA. 84:3365.
13. Espevik, T., and J. Nissen-Meyer. 1986. A highly sensitive cell line WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods. 95:99.
14. Traversari, C., P. van der Bruggen, B. Van den Eynde P. Hainaut, C. Lemoine, N. Ohta, L. Old, and T. Boon. 1992. Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes. Immunogenetics. 35:145.
15. Atherton, E., C.J. Logan, and R.C. Sheppard. 1981. Peptide synthesis. Part 2. Procedures for solid phase synthesis using Nα-fluorenylmethysoxycarbamylamino-acid on polymide supports. Synthesis of substance P and of acyl carrier protein 65-74 decapeptide. J. Chem. Soc. Lond. Perkin Trans. 1:538.
16. Boon, T., J. Van Snick, A. Van Pel, C. Uyttenhove, and M. Marchand. 1980. Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. II. T lymphocyte-mediated cytolysis. J. Exp. Med. 152:1184.
17. Davis, L.G., M.D. Dibner, and J.F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier, New York., pp. 130-135.
18. Brasseur, F., M. Marchand, R. Vanwijck, M. Hérin, B. Lethé, P. Chomez, and T. Boon. 1992. Human gene MAGE-1, which codes for a tumor rejection antigen, is expressed by some breast tumors. Int. J. Cancer. 52:839.
19. Maryanski, J.L., P. Romero, A. Van Pel, T. Boon F.R. Salemme, J.-C. Cerottini, and G. Corradin. 1991. The identification of tyrosine as a common key residue in unrelated H-2Kd restricted antigenic peptides. Int. Immunol. 3:1035.
20. Falk, K., O. Rötzschke, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature (Lond.). 351-290.
21. Hill, A.V.S., J. Elvin, A.C. Willis, M. Aidoo, C.E.M. Allsopp, F.M. Gotch, X.M. Gao, M. Takiguchi, B.M. Greenwood A.R.M. Townsend, and A.J. McMichael. 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature (Lond.). 360:434.
22. Townsend, A., J. Rothbard, F. Gotch, G. Bahadur, D. Wraith, and A. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell. 44:959.
23. McMichael, A.J., F.M. Gotch, and J. Rothbard. 1986. HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. J. Exp. Med. 164:1397.
24. Robbins, P.A., L.A. Lettice, P. Rota, J. Santos-Aguado, J. Rothbard, A.J. McMichael, and J.L. Strominger. 1989. Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. J. Immunol. 143:4098.
25. Pazmani, L., S. Rowland-Jones, S. Huet, A. Hill, J. Sutton, R. Murray, J. Brooks, and A. McMichael. 1992. Genetic modulation of antigen presentation by HLA-B27 molecules. J. Exp. Med. 175:361.
26. Silver, M.L., H.-C. Guo, J.L. Strominger, and D.C. Wiley. 1992. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature (Lond.). 360:367.
27. Jardetzky, T.S., W.S. Lane, R.A. Robinson, D.R. Madden, and D.C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature (Lond.). 353:326.
28. DiBrino, M., K.C. Parker, J. Shiloach, M. Knierman, J. Lukszo, R.V. Turner, W.E. Biddison, and J.E. Coligan. 1993. Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides. Proc. Natl. Acad. Sci. USA. 90:1508.
29. Falk, K., O. Rötzschke, B. Grahovac, D. Schendel, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1993. Peptide motifs of HLA-B35 and -B37 molecules. Immunogenetics. 38:161.
30. Zhang, Q.-J., R. Gavioli, G. Klein, and M.G. Masucci. 1993. An HLA-A11-specific motif in nonamer peptides derived from viral and cellular proteins. Proc. Natl. Acad. Sci. USA. 90:2217.
31. Townsend, A., T. Elliott, V. Cerundolo, L. Foster, B. Barber, and A. Tse. 1990. Assembly of MHC class I molecules analyzed in vitro. Cell. 62:285.
32. Elvin, J., V. Cerundolo, T. Elliott, and A. Townsend. 1991. A quantitative assay of peptide-dependent class I assembly. Eur. J. Immunol. 21:2025.
33. Parker, K.C., M.A. Bednarek, L.K. Hull, U. Utz, B. Cunningham, H.J. Zweerink, W.E. Biddison, and J.E. Coligan. 1992. Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2. J. Immunol. 149:3580.
34. Macatonia, S.E., P.M. Taylor, S.C. Knight, and B.A. Askonas. 1989. Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J. Exp. Med. 169:1255.
35. De Bruijn, M.L.H., J.D. Nieland, T.N.M. Schumacher, H.L. Ploegh, W.M. Kast, and C.J.M. Melief. 1992. Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses. Eur. J. Immunol. 22:3013.
36. Houbiers, J.G.A., H.W. Nijman, S.H. van der Burg, J.W. Drijfhout, P. Kenemans, C.J.H. van de Velde, A. Brand, F. Momburg, M.W. Kast, and C.J.M. Melief. 1993. In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53. Eur. J. Immunol. 23:2072.
37. Weynants, P., B. Lethé, F. Brasseur, M. Marchand, and T. Boon. 1994. Expression of MAGE genes by non-small cell lung carcinomas. Int. J. Cancer. In press.
38. Schild, H., K. Deres, K.H. Wiesmuller, G. Jung, and H.G. Rammensee. 1991. Efficiency of peptides and lipopeptides for in vivo priming of virus-specific cytotoxic T cells. Eur. J. Immunol. 21:2649.
39. Romero, P., G. Eberl, J.L. Casanova, A.S. Cordey, C. Widmann, I.F. Luescher, G. Corradin, and J.L. Maryanski. 1992. Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule. J. Immunol. 148:1871.
40. Feltkamp, M.C.W., H.L. Smits, M.P.M. Vierboom, R.P. Minnaar, B.M. de Jongh, J.W. Drijfhout, J. ter Schegget, C.J.M. Melief, and W.M. Kast. 1993. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by Human Papillomavirus type 16-transformed cells. Eur. J. Immunol. 23:2242.
41. 2-microglobulin as an adjuvant. J. Immunol. 150:1244.