Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

Journal of Clinical Investigation

Volumn 94, Issue 2, 1994, Pages 749-760

  Cope, A P ^a   Londei, M ^a   Chu, N R ^a   Cohen, S B A ^a   Elliott, M J ^a   Brennan, F M ^a   Maini, R N ^a   Feldmann, M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell mediated immunity; immunosuppression; rheumatoid arthritis; T lymphocytes; tumor necrosis factor

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LYMPHOTOXIN; MONOCLONAL ANTIBODY; OKT 3; PHYTOHEMAGGLUTININ; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY DISEASE; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION;

EID: 0027978457     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117394     Document Type: Article

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