Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues

Cancer Chemotherapy and Pharmacology

Volumn 34, Issue 5, 1994, Pages 434-438

  Oblong, John E ^a   Chantler, Edmundo L ^a   Gallegos, Alfred ^a   Lyn Kirkpatrick, D ^b   Chen, Tao ^b   Marshall, Nicole ^b   Powis, Garth ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF REGINA   (Canada)

Author keywords

Disulphides; Growth inhibition; Thioredoxin; Thioredoxin reductase

Indexed keywords

1 METHYLPROPYL 2 IMIDAZOLYL DISULFIDE; 5,5' DITHIOBIS(2 NITROBENZOIC ACID); ALKYL 2 IMIDAZOLYL DISULFIDE DERIVATIVE; CYTOTOXIC AGENT; GLUTATHIONE; N BUTYL 2 IMIDAZOLYL DISULFIDE; N DECYL 2 IMIDAZOLYL DISULFIDE; PLACENTA ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CELL DIVISION; CELL LINE; DISULFIDES; FEMALE; FIBROBLASTS; HUMAN; IMIDAZOLES; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIOREDOXIN; THIOREDOXIN REDUCTASE (NADPH);

EID: 0027977906     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/BF00685570     Document Type: Article

References (19)

1. Thioredoxin
2. Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity
3. ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin: possible involvement of dithiol-reduction in the IL-2 receptor induction
4. Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin
5. Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin
6. Redox regulation of fos and jun DNA-binding activity in vitro
7. In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes
8. Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bond involving cysteine 62
9. Reduction of ribonucleotides
10. Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin
11. Rat liver thioredoxin and thioredoxin reductase: purification and characterization
12. Purification of human thioredoxin reductase: properties and characterization by absorption and circular dichroism spectroscopy
13. Synthesis and evaluation of imidazolyl disulfides for selective cytotoxicity to hypoxic EMT6 tumor cells in vitro
14. Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells
15. Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds
16. The mechanism of action of the nitrosoureas anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase
17. The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid
18. Free radical reduction by thioredoxin reductase at the surface of normal and vitiliginous human keratinocytes