Synaptotagmin can cause an immune‐mediated model of Lambert‐Eaton myasthenic syndrome in rats

Annals of Neurology

Volumn 35, Issue 1, 1994, Pages 74-80

  Takamori, Masaharu ^a   Hamada, Toshio ^a   Komai, Kiyonobu ^a   Takahashi, Masami ^b   Yoshida, Akira ^b  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^b MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CALCIUM CHANNEL; CALCIUM ION; CELL SURFACE PROTEIN; SYNAPTOTAGMIN;

ANIMAL CELL; ANIMAL MODEL; ANTIGENICITY; ARTICLE; CHO CELL; CONTROLLED STUDY; EATON LAMBERT SYNDROME; ENDPLATE POTENTIAL; EXOCYTOSIS; FACILITATION; FEMALE; IMMUNOBLOTTING; MINIATURE ENDPLATE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMAL; CHO CELLS; CRICETULUS; DISEASE MODELS, ANIMAL; FEMALE; HAMSTERS; IMMUNIZATION; LAMBERT-EATON MYASTHENIC SYNDROME; MEMBRANE GLYCOPROTEINS; MICROELECTRODES; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; RATS; RATS, INBRED LEW; SUPPORT, NON-U.S. GOV'T; SYNAPTIC TRANSMISSION;

EID: 0027976873     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410350112     Document Type: Article

References (42)

1. Quantal components of end‐plate potentials in the myasthenic syndrome
2. The Lambert‐Eaton myasthenic syndrome. A review of 50 cases
3. The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse
4. 2+ flux in a human small cell carcinoma line
5. Autoimmunity to the voltage‐gated calcium channels underlies the Lambert‐Eaton my‐asthenic syndrome, a paraneoplastic disorder
6. Autoantibodies bind solubilized calcium channel‐ω‐conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert‐Eaton myasthenic syndrome
7. Specificity of calcium channel autoantibodies in Lambert‐Eaton myasthenic syndrome
8. Calcium channel autoantibodies in the Lambert‐Eaton myasthenic syndrome
9. Calcium channel antagonist: ω‐conotoxin defines a new high affinity site
10. Selective action of myasthenic syndrome antibodies on calcium channels in a rodent neuroblastoma × glioma cell line
11. IgG from patients with Lambert‐Eaton syndrome blocks voltage‐dependent calcium channels
12. Immunoglobulins of Lambert‐Eaton myasthenic syndrome inhibit rat pituitary hormone release
13. P‐type voltage‐dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses
14. Molecular diversity of neuronal‐type calcium channels identified in small cell lung carcinoma
15. Monoclonal antibodies against calcium channels
16. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
17. Domain structure of synaptotagmin (p65)
18. Neurotransmitter release from synaptotagmin‐deficient clonal variants of PC12 cells
19. Automated synthesis of peptides. Solid‐phase peptide synthesis, a simple and rapid synthesis method, has now been automated
20. Empirical predictions of protein conformation
21. A simple method for displaying the hydropathic character of a protein
22. A sequence pattern common to T cell epitopes
23. Myasthenogenicity in the main immunogenic region of acetylcholine receptor as modified by conformational design: an approach to antigenic synthetic peptides
24. + currents of muscarinic acetylcholine receptor subtypes in NG108‐15 cells
25. 2+/calmodulin‐dependent protein kinase II phosphorylate: a novel 58‐kDa protein in synaptic vesicles
26. The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert‐Eaton myasthenic syndrome antigen
27. Selected IgG rapidly induces Lambert‐Eaton myasthenic syndrome in mice: complement independence and EMG abnormalities
28. On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end‐plates
29. Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouse
30. Conformational modification enhances myasthenogenicity in synthetic peptide of acetylcholine receptor α‐subunit
31. Synthetic peptides used to locate the α‐bungarotoxin binding site and immunogenic regions on α subunits of the nicotinic acetylcholine receptor
32. Presynaptic receptors in the neuromuscular junction
33. Does curare affect transmitter release?
34. Chemistry of antibody binding to a protein
35. The immunodominant site of a synthetic immunogen has a conformational preference in water for a type‐II reverse turn
36. T‐cell antigenic sites tend to be amphipathic structures
37. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
38. Cloning and characterization of a Lambert‐Eaton myasthenic syndrome antigen
39. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
40. Primary structure of the b subunit of the DHP‐sensitive calcium channel from skeletal muscle
41. High‐resolution epitope mapping and fine antigenic characterization of the main immunogenic region of the acetylcholine receptor. Improving the binding activity of synthetic analogues of the region