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Volumn 35, Issue 52, 1994, Pages 9689-9692

Aspartimide formation in base-driven 9-fluorenylmethoxycarbonyl chemistry

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID DERIVATIVE; ASPARTIMIDE; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

EID: 0027973175     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(94)88360-2     Document Type: Article
Times cited : (64)

References (19)
  • 1
    • 0001926444 scopus 로고
    • Solid-phase peptide synthesis
    • E. Gross, J. Meienhofer, Academic Press, New York
    • (1979) The Peptides , vol.2 , pp. 193-196
    • Barany1    Merrifield2
  • 6
    • 84912979723 scopus 로고    scopus 로고
    • There is only one previous mention of this side reaction in Fmoc chemistry. See reference 15.
  • 7
    • 84913011487 scopus 로고    scopus 로고
    • 2-terminal Fmoc protecting group with 20% piperidine in DMF (v/v) was typically carried out for 20 min.
  • 9
    • 84912972361 scopus 로고    scopus 로고
    • 2O and 9.5 ml TFA.
  • 10
    • 84912967565 scopus 로고    scopus 로고
    • 2O in 0.045% TFA. Buffer B contained 60% acetonitrile in 0.037% TFA. the model peptides were eluted with 100% buffer A for 3 minutes and 0–22% buffer B linear gradient over 22 min at 1.5 ml/min, monitored at 220 nm.
  • 11
    • 84912996025 scopus 로고    scopus 로고
    • The extent of formation of aspartimide and piperidine adduct between Asp and Asn (or between Asp and Gly) is less pronounced in the model peptide studies than in the synthesis of EGF-like peptide containing -Asp-Asn-.
  • 19
    • 84913014623 scopus 로고    scopus 로고
    • Yang, Y; Sweeney, W.V.; Thörnqvist, S.; Schneider, K.; Chait, B.T.; Tam, J.P. In Techniques in Protein Chemistry VI. Crabb, J. Eds.; Academic Press: New York, In press


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.