Synthesis and Biological Activity of 3-[2-(Dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and Analogs: Agonists for the 5-HT1D Receptor

Journal of Medicinal Chemistry

Volumn 37, Issue 19, 1994, Pages 3023-3032

  Castro, José L ^a,b   Baker, Raymond ^a,b   Guiblin, Alexander R ^a,b   Hobbs, Sarah C ^a,b   Jenkins, Matthew R ^a,b   Russell, Michael G N ^a,b   Beer, Margaret S ^a,c   Stanton, Josephine A ^a,c   Scholey, Kate ^a,d   Hargreaves, Richard J ^a,d   Graham, Michael I ^a,e   Matassa, Victor G ^a,b  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b Merck Sharp & Dohme Research Laboratories ^*  (United Kingdom)

^c Chemistry Departments ^*  (United Kingdom)

^d Biochemistry Departments ^*  (United Kingdom)

^e Pharmacology Departments ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (DIMETHYLAMINO)ETHYL] 5 [(1,1 DIOXO 5 METHYL 1,2,5 THIADIAZOLIDIN 2 YL)METHYL] 1H INDOLE; SEROTONIN ANTAGONIST; SUMATRIPTAN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; RECEPTOR BINDING; SEROTONINERGIC SYSTEM; STRUCTURE ACTIVITY RELATION;

ANIMAL; COMPARATIVE STUDY; DRUG STABILITY; IN VITRO; INDOLES; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; RABBITS; SAPHENOUS VEIN; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRYPTAMINES;

EID: 0027973162     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00045a006     Document Type: Article

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