IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease

Journal of Immunology

Volumn 153, Issue 9, 1994, Pages 4040-4047

  Via, Charles S ^a   Rus, Violetta ^a   Cately, Maurice K ^b   Finkelman, Fred D ^c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYTOKINE; DNA ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G3; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ACUTE DISEASE; ANIMAL CELL; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL TRANSFER; CHRONIC DISEASE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HUMORAL IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD3; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CELLS, CULTURED; CHRONIC DISEASE; CYTOTOXICITY TESTS, IMMUNOLOGIC; FLOW CYTOMETRY; GRAFT VS HOST DISEASE; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0027971672     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
2. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, M. P. Beckmann, L. S. Park, R. L. Coffman, K. A. Schooley, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
3. Murray, H. W., G. L. Spitalny, and C. F. Nathan. 1985. Activation of mouse peritoneal macrophages in vitro and in vivo by IFN-γ. J. Immunol. 134:1619.
4. Svetic, A., K. B. Madden, X. di Zhou, P. Lu, I. M. Katona, F. D. Finkelman, J. F. Urban, and W, C. Gause. 1993. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J. Immunol. 150:3434.
5. Stevens, T. L., A. Bossie, M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, and E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255.
6. Madden, K. B., J. F. Urban, H. J. Ziltener, J. W. Schrader, F. D. Finkelman, and I. M. Katona. 1991. Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J. Immunol. 147: 1387.
7. Gleichmann, E., S. T. Pals, A. G. Rolink, T. Radaszkiewicz, and H. Gleichmann. 1984. Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases. Immunol. Today 5:324.
8. De Wit, D., M. Van Mechelen, C. Zanin, J. Doutrelepont, T. Velu, C. Gerard, D. Abramowicz, J. Scheerlinck, P. De Baetselier, J. Urbain, O, Leo, M. Goldman, and M. Moser. 1993. Preferential activation of Th2 cells in chronic graft-versus-host reaction. J. Immunol. 150:361.
9. Doutrelepont, J. M., M. Moser, O. Leo, D. Abramowicz, M. L. Vanderhaegen, J. Urbain, and M. Goldman. 1991. Hyper IgE in stimulatory graft-versus-host disease: role of interleukin-4. Clin. Exp. Immunol. 83:133.
10. Claman, H. N., and H. L. Spiegelberg. 1990. Immunoglobulin dysregulation in murine graft-vs-host disease: a hyper-IgE syndrome. Clin. Immunol. Immunopathol. 56:46.
11. Via, C. S., S. O. Sharrow, and G. M. Shearer. 1987. Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease. J. Immunol. 139:1840.
12. Via, C. S., and G. M. Shearer. 1988. T-cell interactions in autoimmunity: insights from a murine model of graft-versus-host disease. Immunol. Today 9:207.
13. Umland, S. P., S. Razac, D. K. Nahrebne, and B. W. Seymour. 1992. Effects of in vivo administration of interferon (IFN)-γ, anti-IFN-γ, or anti-interleukin-4 monoclonal antibodies in chronic autoimmune graft-versus-host disease. Clin. Immunol. Immunopathol. 63:66.
14. Via, C. S., and F. D. Finkelman. 1993. Critical role of interleukin-2 in the development of acute graft-versus-host disease. Int. Immunol. 5:565.
15. Manetti, R. P., P. Parronchi, M. G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12) induces T helper type 1-specific immune responses and inhibits the development of IL-4 producing cells. J. Exp. Med. 177:1199.
16. Stern, A. S., F. J. Podalski, J. D. Hulmes, Y. E. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Truitt, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
17. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
18. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, and G. Trinchieri. 1991. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
19. Gately, M. K., A. G. Wolitzky, P. M. Quinn, and R. Chizzonite. 1992. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell. Immunol. 143:127.
20. + T lymphocytes. J. Immunol. 151:2444.
21. Gately, M. K., R. R. Warrier, S. Honsago, D. M. Carvajal, D. A. Faherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R. Hubbard, and M. Murphy. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. In press.
22. Cherwinski, H. M., J. H. Schumacher, K. D. Brown, and T. R. Mosmann. 1987. Two types of mouse T helper clone. III. Further differences in Iymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally non-specific bioassays and monoclonal antibodies. J. Exp. Med. 166:1229.
23. Malek, T. R., R. J. Robb, and E. M. Shevach. 1983. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proc. Natl. Acad. Sci. USA 80:5684.
24. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J, A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
25. Unkeless, J. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
26. Finkelman, F. D., C. M. Snapper, J. D. Mountz, and I. M. Katona. 1987. Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response. J. Immunol. 138:2826.
27. Rozendaal, L., S. T. Pals, M. Schilham, C. J. M. Melief, and E. Gleichmann. 1989. Allosuppression of B cells in vitro by graftvs-host reaction-derived T cells is caused by cytotoxic T lymphocytes. Eur. J. Immunol. 19:1669.
28. Allen, R. D., T. A. Staley, and C. L. Sidman. 1993. Differential cytokine expression in acute and chronic murine graft-versus-host disease. Eur. J. Immunol. 23:333.
29. Via, C. S., A. Svetic, F. D. Finkelman, and W. C. Gause. 1992. Early cytokine production in a murine model of lupus. FASEB J. 6:A1447 (Abstr.).
30. Oehen, S., H. Hengartner, and R. M. Zinkernagel. 1991. Vaccination for disease. Science 251:195.
31. Finkelman, F. D., I. M. Katona, T. R. Mosmann, and R. L. Coffman. 1988. IFN-γ regulates the isotypes of Ig secreted during in vivo humoral immune responses. J. Immunol. 140:1022.
32. Finkelman, F. D., K. B. Madden, A. W. Cheever, I. M. Katona, S. C. Morris, M. K. Gately, B. R. Hubbard, W. C. Gause, and J. F. Urban. 1994. Effects of interleukin-12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179:1563.
33. Graham, M. B., D. K. Dalton, D. Giltinan, V. L. Braciale, T. A. Stewart, and T. J. Braciale. 1993. Response to influenza infection in mice with a targeted disruption in the interferon-γ gene. J. Exp. Med. 178:1725.