Investigation of the role of signal transduction in attachment of ocular melanoma cells to matrix proteins: inhibition of attachment by calmodulin antagonists including tamoxifen

Clinical & Experimental Metastasis

Volumn 12, Issue 6, 1994, Pages 375-384

  Neil, S Mac ^a   Wagner, M ^a   Rennie, I G ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

calmodulin antagonists; ocular melanoma; signal transduction

Indexed keywords

2',3' DIDEOXYADENOSINE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; ARGININE; ASPARTIC ACID; CALCIUM; CALMODULIN INHIBITOR; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CYCLIC AMP; FIBRONECTIN; FORSKOLIN; GELATIN; GENISTEIN; GLYCINE; IONOMYCIN; LAMININ; MATRIX PROTEIN; NAPHTHALENESULFONAMIDE DERIVATIVE; PLASTIC; POLYLYSINE; PROTEIN KINASE C; STAUROSPORINE; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; EYE CANCER; HUMAN; HUMAN CELL; MELANOMA; METASTASIS; SIGNAL TRANSDUCTION;

CALCIUM; CALMODULIN; CELL ADHESION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EXTRACELLULAR MATRIX PROTEINS; EYE NEOPLASMS; IN VITRO; MELANOMA; PROTEIN BINDING; PROTEIN KINASE C; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TAMOXIFEN; TUMOR CELLS, CULTURED; UVEAL NEOPLASMS;

EID: 0027970961     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/BF01755881     Document Type: Article

References (17)

1. From adhesion to signalling: Roles of integrins in the biology of human melanoma
2. Protein kinase C involvement in focal adhesion formation
3. Intracellular regulation of cell adhesion to extracellular matrix components in murine B16 melanoma cells of differing metastatic potential
4. Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase
5. Ca2+-dependent binding of tamoxifen to calmodulin isolated from bovine brain
6. Inhibition of melanoma cell/matrix interaction by tamoxifen
7. Distribution of tamoxifen and its metabolites in rat and human tissues during steady state treatment
8. Calmodulin antagonists of improved potency and specificity for use in the study of calmodulin biochemistry
9. Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells and retinal epithelial cells
10. ESTA: a bioassay system for the determination of the potencies of hormones and antibodies which mimic their action
11. Evidence for a calcium/calmodulin involvement in density-dependent melanogenesis in murine B16 melanoma cells
12. Integrins: versatility, modulation and signalling in cell adhesion
13. Focal adhesions and cell/matrix interactions
14. Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity
15. A comparative study of the antiproliferative effects of calmodulin antagonists in cultured cells-W7 derivatives of improved cytostatic potential
16. Treatment of metastatic malignant melanoma with dacarbazine plus tamoxifen