Mechanism of cisplatin nephrotoxicity in rat renal proximal tubule suspensions

Toxicology in Vitro

Volumn 8, Issue 6, 1994, Pages 1203-1212

  McGuinness, S J ^a   Ryan, M P ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; ANTINEOPLASTIC AGENT; CISPLATIN; IODOACETIC ACID; N ACETYL BETA GLUCOSAMINIDASE; POTASSIUM CYANIDE; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; KIDNEY PROXIMAL TUBULE; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; RAT;

ANIMALIA; STROPHANTHUS GRATUS;

EID: 0027970318     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/0887-2333(94)90110-4     Document Type: Article

References (49)

1. Ultrastructural effects of cisplatin
2. Primary cultures of rat and rabbit renal proximal epithelium as models for nephrotoxicity investigations
3. Protective effect of organic cation transport inhibitors on cis-diamminedichloroplatinum-induced nephrotoxicity
4. Cisplatin nephrotoxicity and platinum-metallothioneins: uptake and toxicity in proximal tubular cells from rat kidney
5. Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules.
6. Microsomal lipid peroxidation
7. Plasma platinum levels: relationship to cisplatin dose and nephrotoxicity
8. Cis-Platin cytotoxicity in human and rat tubular cell cultures
9. The respiratory chain and oxidative phosphorylation
10. Subcellular localisation of cis-dichlorodiammineplatinum (II) in rat kidney and liver
11. Acute and chronic cisplatin nephropathy in rats.
12. Cis-diamminedichlorplatinum-induced acute renal failure in the rat
13. The inhibition of renal ATPase by cisplatin and some biotransformation products
14. Long term effect of cis-diamminedichloride platinum (CDDP) on renal function and structure in man
15. Long-term consequences of cis-platinum-induced renal injury: a structural and functional study
16. Mechanism of cis-platinum nephrotoxicity: II. Morphologic observations
17. Model independent pharmacokinetic study of cis-dichlorodiammineplatinum (II)
18. Use of cultured renal epithelial cells for the study of cisplatin toxicity
19. Evaluation of cisplatin-induced lipid peroxidation in rat renal tissues by means of slice technique
20. Improved separation method for rat proximal and distal renal tubules.
21. The renal pathology in clinical trials of cis-platinum (II) diamminedichloride
22. Mitochondrial alterations in cisplatin-induced acute renal failure.
23. Platinate toxicity. Past, present and prospects
24. Cisplatin-induced lipid peroxidation and decrease in gluconeogenesis in rat kidney cortex: different effects of antioxidants and radical scavengers
25. +-dependent adenosine triphosphatase-mediated ion transport in the intact renal cell
26. Cis-Diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations
27. Tissue injury and proliferative response induced in rat kidney by cis-diamminedichloroplatinum (II)
28. Studies on glucosaminidase 4. The fluorimetric assay of N-acetyl-β-glucosaminidase
29. Diagnosis and treatment. Drugs five years later. Cisplatin
30. Protein measurement with the Folin phenol reagent
31. Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase)
32. Effect of cisplatin on isolated rat kidney proximal tubule fragments: an in vitro model for nephrotoxicity studies
33. Investigation of cisplatin toxicity in rat renal proximal tubular fragments
34. Platinum nephrotoxicity
35. Potentiation of cisplatin-induced lipid peroxidation in kidney cortical slices by glutathione depletion
36. Characteristics of inhibition of human renal adenosine triphosphatases by cisplatin and chloroplatinic acid
37. Cisplatin and analogues: a new class of anticancer drugs
38. Reduction of the renal toxicity of cis-dichlorodiammineplatinum (II) by probenecid
39. Uptake and metabolism of cisplatin by rat kidney
40. Effects of cis-diamminedichloroplatinum (Cis-P) on renal cortical mitochondrial respiration: a primary pathogenic event in Cis-P nephrotoxicity
41. Free-radical mechanisms in tissue injury
42. Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues
43. Interaction of cis-diamminedichloroplatinum (II) with mitochondrial phosphate carrier
44. The effect of cisplatin on renal ATPase activity in vivo and in vitro
45. The role of lipid peroxidation in the nephrotoxocity of cisplatin
46. Isolation of a pure suspension of rat proximal tubules
47. The nephrotoxic effects of cis-diammine-dichloroplatinum (II) (NSC 119875) in male F344 rats
48. Effect of cisplatin on organic ion transport in membrane vesicles from rat kidney cortex
49. Role of mitochondria in cisplatin-induced oxidative damage exhibited by rat renal cortical slices