Effects of P‐glycoprotein expression on cyclic AMP and volume‐activated ion fluxes and conductances in HT‐29 colon adenocarcinoma cells

Journal of Cellular Physiology

Volumn 161, Issue 3, 1994, Pages 393-406

  Kunzelmann, K ^a   Slotki, I N ^b,c   Klein, P ^a   Koslowsky, T ^a   Ausiello, D A ^d   Greger, R ^a   Cabantchik, Z I ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,9 DIDEOXYFORSKOLIN; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; BARIUM; CYCLIC AMP; GLYCOPROTEIN P; TRANSMEMBRANE CONDUCTANCE REGULATOR; VERAPAMIL;

ARTICLE; CARCINOMA CELL; CELL VOLUME; CHLORIDE CONDUCTANCE; COLON ADENOCARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PATCH CLAMP; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ADENOCARCINOMA; CHLORIDES; COLONIC NEOPLASMS; CYCLIC AMP; FORSKOLIN; HUMAN; IN VITRO; ION CHANNEL GATING; OSMOLAR CONCENTRATION; P-GLYCOPROTEIN; POTASSIUM; RHODAMINE 123; RHODAMINES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0027967523     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.1041610302     Document Type: Article

References (56)

1. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity
2. Nucleotide triphosphates are required to open the CFTR channel
3. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus
4. Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus
5. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator
6. Quantitative expression patterns of multidrug‐resistance P‐glycoprotein (MDR1) and differentially spliced cystic fibrosis transmembrane conductance regulator mRNA transcripts in human epithelia
7. Induction of expression of the cystic fibrosis transmembrane conductance regulator
8. Protein kinase C mediates down‐regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells
9. Induction of multidrug resistance (MDR) down‐regulates the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in colon epithelial cells
10. Phosphorylation of the R domain by cAMP‐dependent protein kinase regulates the CFTR chloride channel
11. Immunocytochemical localization of the cystic fibrosis gene product CFTR
12. A model for computer simulation of P‐glycoprotein and transmembrane delta pH mediated anthracycline transport in multidrug resistant tumor cells
13. The Biochemistry of P‐glycoprotein‐mediated multidrug resistance
14. New human tumor cell lines
15. Pharmacology of drugs that alter multidrug resistance in cancer
16. + current in human tacheal cells
17. Separation of drug transport and chloride channel functions of the human multidrug resistance P‐glycoprotein
18. Resistance to multiple chemotherapeutic agents in human cancer cells
19. The multidrug transporter, a double‐edged sword
20. Chloride transporting epithelia
21. Regions involved in the opening of ClC‐2 chloride channel by voltage and cell volume
22. Plasma and mitochondrial transmembrane potentials in adriamycin resistant and sensitive Friend leukemia cells as determined by flow cytometry
23. + channels in the larval frog skin
24. Membrane mechanisms in volume and pH regulation in vertebrate cells
25. Fluorescent cellular indicators are extruded by the multidrug resistance protein
26. Structural model of ATP‐binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
27. The function of GP‐170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
28. Increased cytosolic pH in multidrug resistant human lung tumor cells: Effect of verapamil
29. Expression of the cystic fibrosis gene in non‐epithelial invertebrate cells produces a regulated anion conductance
30. Possible link between the intrinsic drug resistance of colon tumors and a detoxification mechanism of intestinal cells
31. 29 cells: Ion selectivity, additivity and stilbene sensitivity
32. cAMP dependent activation of small conductance Cl‐channels in HT29 colon carcinoma cells
33. 2+, hypotonic cell swelling and 8‐Br‐cGMP
34. Identification of P‐glycoprotein in renal brush border membranes
35. Tight‐seal whole cell recording
36. Calcium signalling in volume regulation
37. Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the multidrug resistance P‐glycoprotein
38. P‐glycoprotein as multidrug transporter: A critical review of current multidrug resistant lines
39. 2+ activated cell volume recovery mechanism
40. Cystic fibrosis: A disease in electrolyte transport
41. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
42. Volume activated chloride transport
43. Increase in non‐specific adsorptive endocytosis in anthracycline‐ and Vinca alkaloid‐resistant Ehrlich ascites tumor cells
44. Transport of digoxin by human P‐glycoprotein expressed in a porcine kidney epithelial cell line
45. Cross‐resistance to rhodamine 123 in adriamycin‐ and daunorubicin‐resistant Friend leukemia cell variants
46. Cellular localization of the multidrug‐resistance gene product P‐glycoprotein in normal human tissues
47. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and cross‐reactivity of one antibody with a muscle protein
48. A chloride channel widely expressed in epithelial and non‐epithelial cells
49. Different types of blockers of the intermediate conductance outwardly rectifying chloride channel (ICOR) in epithelia
50. Down‐regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester
51. In vivo cell‐specific expression of the cystic fibrosis transmembrane conductance regulator
52. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression
53. Volume regulated chloride channels associated with the human multidrug resistance P‐glycoprotein
54. Correction of altered plasma membrane potentials. A possible mechanism of cyclosporin A and verapamil reversal of pleiotropic drug resistance in neoplasia
55. Partial reversal of multidrug resistance by forskolin and 1,9‐dideoxyforskolin in murine sarcoma S180 variants
56. Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation