Structures of active conformations of Giα1 and the mechanism of GTP hydrolysis

Science

Volumn 265, Issue 5177, 1994, Pages 1405-1412

  Coleman, David E ^a   Berghuis, Albert M ^a   Lee, Ethan ^b   Linder, Maurine E ^b,c   Gilman, Alfred G ^b   Sprang, Stephen R ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; PROTEIN SUBUNIT;

ARTICLE; ENZYME MECHANISM; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALUMINUM COMPOUNDS; ARGININE; BINDING SITES; CATALYSIS; COMPUTER GRAPHICS; CRYSTALLOGRAPHY, X-RAY; FLUORIDES; GLUTAMINE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HELIX-LOOP-HELIX MOTIFS; HYDROGEN BONDING; HYDROLYSIS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027965652     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.8073283     Document Type: Article

References (55)