In vitro modulation of the invasive and metastatic potentials of human renal cell carcinoma by interleukin‐2 and/or interferon‐alpha gene transfer

Cancer

Volumn 74, Issue 7, 1994, Pages 1904-1911

  Hathorn, Robert W ^a   Tso, Cho‐Lea ^a   Kaboo, Randhir ^a   Pang, Shen ^a   Figlin, Robert ^a   Sawyers, Charles ^a   Dekernion, Jean B ^a   Belldegrun, Arie ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

gene transfection; interferon alpha; interleukin 2; invasion; metastasis; renal cell carcinoma

Indexed keywords

ALPHA INTERFERON; COLLAGEN TYPE 4; COLLAGENASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; LAMININ; VITRONECTIN;

ADVANCED CANCER; ANTIGENIC MODULATION; ARTICLE; CANCER INVASION; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CARCINOMA; METASTASIS; ONCOGENE C MYC; PRIORITY JOURNAL; TUMOR GROWTH;

ANTIGENS, CD44; BASE SEQUENCE; CARCINOMA, RENAL CELL; CARRIER PROTEINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MEMBRANE; COLLAGENASES; DOWN-REGULATION; DRUG RESISTANCE; EXTRACELLULAR MATRIX; GELATINASE B; GENE TRANSFER TECHNIQUES; HUMAN; INTERFERON-ALPHA; INTERLEUKIN-2; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, LYMPHOCYTE HOMING; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0027964373     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19941001)74:7<1904::AID-CNCR2820740713>3.0.CO;2-B     Document Type: Article

References (27)

1. Human renal carcinoma line transfected with interleukin‐2 and/or interferon a gene(s): implications for live cancer vaccine
2. Interferon therapy for renal cell carcinoma
3. Recombinant alpha interferon in renal cell carcinoma: a random trial of two routes of administration
4. Experience with the use of high dose interleukin‐2 in the treatment of 652 cancer patients
5. Phase II trial of high‐dose intermittent interleukin‐2 in renal cell carcinoma: a Southwest Oncology Group study
6. Concomitant administration of recombinant human interleukin‐2 and recombinant interferon alpha‐2A: an active outpatient regimen in metastatic renal cell carcinoma
7. Renal cell carcinoma basic biology and current approaches to therapy
8. Renal tumors
9. Functional evidence that intercellular adhesion molecule‐1(ICAM‐1) is a ligand for LFA‐J‐dependent adhesion in T cell‐mediated cytotoxicity
10. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
11. Motility and adhesive properties of high‐ and low‐metastatic murine neoplastic cells
12. Membrane receptor for extracellular matrix molecules: relationship to cell adhesion and tumor metastasis
13. Malignantmelanoma cell line selected in vitro for increased homotypic adhesion properties have increased experimental metastasis potential
14. Type IV collagenase in tumor invasion and metastasis
15. Correlation of c‐myc expression with nuclear pleomorphism in human renal cell carcinoma
16. Effects of transforming growth factor on human pulmonary adenocarcinoma cell adhesion, motility, and invasion in vitro
17. Aberrant expression of epidermal growth factor receptor and HER‐2(erb B‐2) messenger RNAs in human renal cancer
18. Characterization of the invasive and metastatic phenotype in human renal cell carcinoma
19. Single‐step method of RNA isolated by acid guanidine thiocyanate‐phenol‐chloroform extraction
20. Adhesion molecules controlling lymphocyte migration
21. Modulation of adhesion molecules on human large granulocytes by interleukin‐2 in vivo and in vitro
22. Cell surface expression of ICAM‐1(CD54) and LFA‐3(CD58), two adhesion molecules, is up‐regulated on bone marrow leukemia blasts after in vivo administration of high dose recombinant interleukin‐2
23. T cell‐receptor engagement and tumor ICAM‐1 up‐regulation are required to by‐pass low susceptibility of melanoma cells to autologous CTL‐mediated lysis
24. De novo expression of intercellular‐adhesion molecule 1 in melanoma correlates with increased risk of metastasis
25. Expression of collagenase IV activity in Murine tumor cell hybrids that digger in metastatic potential
26. Expression of transforming growth factor‐a in normal human adult kidney and enhanced expression of transforming growth factors a and b in renal cell carcinoma
27. a‐interferon down regulates epidermal growth factor receptors on renal carcinoma cells: relation to cellular responsiveness to the antiproliferative action of a‐interferon