Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction

Journal of Urology

Volumn 151, Issue 1, 1994, Pages 198-205

  Kim, J H ^a   Klyachkin, M L ^a   Svendsen, E ^a   Davies, M G ^a   Hagen, P O ^a   Carson III, C C ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

atherosclerosis; hypercholesterolemia; impotence; penile erection

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; IMPOTENCE; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; RISK FACTOR; SEXUAL DYSFUNCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER;

EID: 0027958541     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(17)34916-9     Document Type: Article

References (29)

1. R. Virag P. Bouilly D. Frydman Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men Lancet 1 1985 181
2. R.J. Krane I. Goldstein I. Saenz de Tejada Impotence N. Engl. J. Med. 321 1989 1648
3. Y. Vardi H. Padma-Nathan M.B. Siroky Hemodynamics of canine penile erection: direct measurement of venous outflow Surg. Forum 38 1987 649
4. K. Azadzoi I. Goldstein Atherosclerosis-induced corporeal leakage impotence Surg. Forum 38 1987 647
5. F.C. Tanner G. Noll C.M. Boulanger T.F. Lüscher Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries Circulation 83 1991 2012
6. M.E. Rosenfeld Oxidized LDL affects multiple atherogenic cellular responses Circulation 83 1991 2137
7. K. Kugiyama S.A. Kerns J.D. Morrisett R. Roberts P.D. Henry Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins Nature 344 1990 160
8. K.R. Bruckdorfer M. Jacobs C. Rice-Evans Endothelium-derived relaxing factor (nitric oxide), lipoprotein oxidation and atherosclerosis Biochem. Soc. Trans. 18 1990 1061
9. T.Y. Ahn I. Saenz de Tejada Effects of hypercholesterolemia and nitric oxide synthesis inhibition on rabbit corpus cavernosum tissue Int. J. Impot. Res. 4 suppl 2 1992 A5
10. K. Azadzoi I. Saenz de Tejada Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle J. Urol. 146 1991 238
11. D.J. Finney Quantal responses and the tolerance distribution D.J. Finney Statistical Method in Biological Assay 2nd ed. 1978 Charles Griffin and Co., Ltd. London 349 369 chapt. 17
12. N. Chiamori R. Henry Study of the ferric chloride method for determination of total cholesterol and cholesterol esters Am. J. Clin. Path. 31 1959 305
13. R.P. Cody J.K. Smith Applied Statistics and the SAS Programming Language 2nd ed. 1987 North-Holland New York 106 177
14. E. Svendsen Focal endothelial cell injury in rabbit aorta, aggravation of injury by 2 days of cholesterol feeding Acta. Path. Microbiol. Scand. 87 1979 123
15. D. Steinberg S. Parthasarathy T.E. Carew J.C. Khoo J.L. Witzum Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity N. Engl. J. Med. 320 1989 915
16. U.P. Steinbrecher Role of lipoprotein peroxidation in the pathogenesis of atherosclerosis Clin. Cardiol. 14 1991 865
17. T.A. Ahn K.M. Azadzoi I. Saenz de Tejada Oxidized low density lipoproteins elicit contraction of rabbit corpus cavernosum smooth muscle J. Urol. 147 1992 455A
18. R.H.A. Becker G. Wiemer W. Linz Preservation of endothelial function by ramipril in rabbits on a long-term atherogenic diet J. Cardiovasc. Pharm. 18 suppl. 2 1991 S110
19. R.A. Cohen R.M. Weisbrod Endothelium inhibits norepinephrine release from adrenergic nerves of rabbit carotid artery Am. J. Physiol. 254 1988 H871
20. 1 and beta adrenoreceptors in rabbits: effects of dietary sodium and cholesterol Cardiovasc. Res. 21 1987 39
21. Y.-C. Tong G. Broderick J. Hypolite R.M. Levin Correlations of purinergic, cholinergic and adrenergic functions in rabbit corporal tissue Pharmacology 45 1992 241
22. I. Saenz de Tejada N. Kim I. Lagan R.J. Krane I. Goldstein Regulation of adrenergic activity in penile corpus cavernosum J. Urol. 142 1989 1117
23. R.M. Levin J.A. Hypolite G. Broderick Correlation of contraction of the rabbit corpus cavernosum with calcium movements Surg. Forum 42 1991 682
24. J.A. Osborne P.H. Lento M.R. Siegfried G.L. Stahl B. Fusman A.M. Lefer Cardiovascular effects of acute hypercholesterolemia in rabbits: reversal with Lovastatin treatment J. Clin. Invest. 83 1989 465
25. B.M. Rifkind Cholesterol redux J.A.M.A. 264 1990 3060
26. A. Mersdorf P.C. Goldsmith W. Diederichs C.A. Padula T.F. Lue I.J. Fishman E.A. Tanagho Ultrastructural changes in impotent penile tissue: a comparison of 65 patients J. Urol. 145 1991 749
27. M.J. Jevtich N.Y. Khawand B. Vidic Clinical significance of ultrastructural findings in the corpora cavernosa of normal and impotent men J. Urol. 143 1990 289
28. K.-P. Jünemann J. Aufenanger T. Konrad J. Pill B. Berle C. Persson-Jünemann P. Alken The effect of impaired lipid metabolism on the smooth muscle cells of rabbits Urol. Res. 19 1991 271
29. D.G. Harrison R.L. Minor R. Guerra J.E. Quillen W. Selke Endothelial dysfunction in atherosclerosis G.M. Rubanyi Cardiovascular Significance of Endothelium-Derived Vasoactive Factors 1991 Futura Publishing Company, Inc. Mount Kisco, N.Y. 263 280 chapt. 12