Fibroblasts, myofibroblasts, and wound contraction

Journal of Cell Biology

Volumn 124, Issue 4, 1994, Pages 401-404

  Grinnell, Frederick ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CYTOSKELETON; EPITHELIZATION; EXTRACELLULAR MATRIX; GRANULATION TISSUE; MYOFIBROBLAST; PRIORITY JOURNAL; SCAR FORMATION; SHORT SURVEY; SKIN FIBROBLAST; WOUND CLOSURE; WOUND CONTRACTION;

EID: 0027955331     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.124.4.401     Document Type: Short Survey

References (74)

1. Abercrombie, M., M. H. Flint, and D. W. James. 1956. Wound contraction in relation to collagen formation in scorbutic guinea pigs. J. Embryol. Exp. Morphol. 4:167-175.
2. Arem, A. J., and J. W. Madden. 1976. Effects of stress on healing wounds. I. Interminent noncyclical tension. J. Surg. Res. 20:93-102.
3. Bell, E., B. Ivarsson, and C. Merrill. 1979. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc. Natl. Acad. Sci. USA. 76:1274-1278.
4. Bellows, C. G., A. H. Melcher, and J. E. Aubin. 1981. Contraction and organization of collagen gels by cell cultured from periodontal ligament, gingiva, and bone suggest functional differences between cell types. J. Cell Sci. 50:299-314.
5. Bellows, C. G., A. H. Melcher, and J. E. Aubin. 1982. Association between tension and orientation of periodontal ligament fibroblasts and exogenous collagen fibres in collagen gels in vitro. J. Cell Sci. 58:125-138.
6. Billingham, R. E., and P. S. Russell. 1956. Studies on wound healing, with special reference to the phenomenon of contracture in experimental wounds in rabbits' skin. Ann. Surg. 144:961-981.
7. Burgess, L. P. A., G. V. Morin, M. Rand, J. Vossoughi, and J. O. Hollinger. 1990. Wound healing: relationship of wound closing tension to scar width in rats. Arch. Otolaryngol. Head & Neck Surg. 116:798-802.
8. Clark, R. A. F. 1988. Overview and general considerations of wound repair. In The Molecular and Cellular Biology of Wound Repair. R. A. F. Clark and P. M. Henson, editors. Plenum Press, New York. 3-33.
9. Clark, R. A. F. 1993. Regulation of fibroplasia in cutaneous wound repair. Am. J. Med. Sci. 306:42-48.
10. Clark, R. A. F., J. M. Folkvord, C. E. Hart, M. J. Murray, and J. M. McPherson. 1989. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J. Clin. Invest. 84:1036-1040.
11. Danowski, B. A., and A. K. Harris. 1988. Changes in fibroblast contractility, morphology, and adhesion in response to a phorbol ester tumor promoter. Exp. Cell Res. 177:47-59.
12. Darby, I., and G. Gabbiani. 1990. α-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Invest. 63:21-29.
13. Delvoye P., R. Wiliquet, J.-L. Leveque, B. V. Nusgens, and C. M. Lapiere. 1991. Measurement of mechanical forces generated by skin fibroblasts embedded in the three-dimensional collagen gel. J. Invest. Dermatol. 97: 898-902.
14. Desmouli, A., A. Geinoz, F. Gabbiani, and G. Gabbiani. 1993. Transforming growth factor beta-1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 122:103-111.
15. Dubertret, L., F. Brunner-Ferber, J. Misiti, K. A. Thomas, and M.-L. Dubertret. 1991. Activities of human acidic fibroblast growth factor in an in vitro dermal equivalent model. J. Invest. Dermatol. 97:793-798.
16. Eckes, B., C. Mauch, G. Huppe, and T. Krieg. 1993. Downregulation of collagen synthesis in fibroblasts within three-dimensional collagen lattices involves transcriptional and posttranscriptional mechanisms. FEBS (Fed. Eur. Biochem. Soc.) Lett. 318:129-133.
17. Eddy, R. J., J. A. Petro, and J. J. Tomasek. 1988. Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertrophic scar. Am. J. Pathol. 130:252-260.
18. Ehrlich, H. P., and T. R. Griswold. 1984. Epidermolysis bullosa dystrophica recessive fibroblasts produce increased concentrations of cAMP within a collagen matrix. J. Invest Dermatol. 83:230-233.
19. Ehrlich, H. P., W. B. Rockwell, T. L. Cornwell, and J. B. M. Rajaratnam. 1991. Demonstration of a direct role for myosin light chain kinase in fibroblast-populated collagen lattice contraction. J. Cell Physiol. 146:1-7.
20. Elsdale, T., and J. Bard. 1972 Collagen substrata for studies on cell behavior. J. Cell Biol. 54:626-637.
21. Farsi, J. M. A., and J. E. Aubin. 1984. Microfilament rearrangements during fibroblast induced contraction of three-dimensional hydrated collagen gels. Cell Motil. 4:29-40.
22. Finesmith, T. H., K. N. Broadley, and J. M. Davidson. 1990. Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors. J. Cell Physiol. 144:99-107.
23. Fukamizu, H., and F. Grinnell. 1990. Spatial organization of extracellular matrix and fibroblast activity: Effects of serum, transforming growth factor b, and fibronectin. Exp. Cell Res. 190:276-282.
24. Gabbiani, G., B. J. Hirschel, G. B. Ryan, P. R. Statkov, and G. Majno. 1972. Granulation tissue as a contractile organ: a study of structure and function. J. Exp. Med. 135:719-733.
25. Gillery, P., H. Serpier, M. Polette, G. Bellon, C. Clavel, Y. Wegrowski, P. Birembaut, B. Kalis, R. Cariou, and F.-X. Maquart. 1992b. Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts. Eur. J. Cell Biol. 57:244-253.
26. Grinnell, F., and C. R. Lamke. 1984. Reorganization of hydrated collagen lattices by human skin fibroblasts. J. Cell Sci. 66:51-63.
27. Guidry, C. 1992. Extracellular matrix contraction by fibroblasts: peptide promoters and second messengers. Canc. Metastasis Rev. 11:45-54.
28. Guidry, C., and F. Grinnell. 1985. Studies on the mechanism of hydrated collagen gel reorganization by human skin fibroblasts. J. Cell Sci. 79:67-81.
29. Guidry, C., and F. Grinnell. 1987. Heparin modulates the organization of hydrated collagen gels and inhibits gel contraction by fibroblasts. J. Cell Biol. 104:1097-1103.
30. Harris, A. K., D. Stopak, and P. Wild. 1981. Fibroblast traction as a mechanism for collagen morphogenesis. Nature (Lond.). 290:249-251.
31. Hunt, T. K., and J. E. Dunphy. 1979. Fundementals of Wound Management. Appleton-Century-Crofts, New York.
32. Iwig, M., D. Glaesser, and M. Bethge. 1981. Cell shape-mediated growth control of lens epithelial cells grown in culture. Exp. Cell Res. 131:47-55.
33. Jain, M. K., R. A. Berg, and G. P. Tandon. 1990. Mechanical stress and cellular metabolism in living soft tissue composites. Biomaterials. 11:465-472.
34. Kasugai, S., S. Suzuki, S. Shibata, S. Yasui, H. Amano, and H. Ogura. 1990. Measurements of the isometric contractile forces generated by dog periodontal ligament fibroblasts in vitro. Arch. Oral Biol. 35:597-601.
35. Klein, C. E., D. Dressel, T. Steinmayer, C. Mauch, B. Eckes, T. Krieg, R. B. Bankert, and L. Weber. 1991. Integrin α2β1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils. J. Cell Biol. 115: 1427-1436.
36. Kolodney, M. S., and R. B. Wysolmerski. 1992. Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study. J. Cell Biol. 117:73-82.
37. Kolodney, M. S., and E. L. Elson. 1993. Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts. J. Biol. Chem. 268:23850-23855.
38. Kono, T., T. Tanii, M. Furukawa, N. Mizuno, J.-I. Katajima, M. Ishii, T. Hamada, and K. Yoshizato. 1990. Cell cycle analysis of human dermal fibroblasts cultured on or in hydrated type I collagen lattices. Arch. Dermatol. Res. 282:258-262.
39. Lambert, C. A., E. P. Soudant, B. V. Nusgens, and C. M. Lapiere. 1992. Pretranslational regulation of extracellular matrix molecules and collagenase expression in fibroblasts by mechanical forces. Lab. Invest. 66:444-451.
40. Larson, D. L., S. Abston, E. B. Evans, M. Dobrkovsky, and H. A. Linares. 1971. Techniques for decreasing scar formation and contractures in the burned patient. J. Trauma. 11:807-823.
41. Lee, T.-L., Y.-C. Lin, K. Mochitate, and F. Grinnell. 1993. Stress-relaxation of fibroblasts in collagen matrices triggers ectocytosis of plasma membrane vesicles containing actin, annexins II and VI, and bl integrin receptors. J. Cell Sci. 105:165-177.
42. Lin, Y.-C., and F. Grinnell. 1993. Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices. J. Cell Biol. 122:663-672.
43. Majno, G. 1975. The Healing Hand. Harvard University Press, Cambridge, MA.
44. Mast, B. A. 1992. Repair of specific tissues: The skin. In Wound Healing: Biochemical and Clinical Aspects, I. K. Cohen, R. F. Diegelmann, and W. J. Lindblad, editors. W.B. Saunders Co., Philadelphia, PA. 344-355.
45. Mauch, C., A. Hatamochi, K. Scharffetter, and T. Krieg. 1988. Regulation of collagen synthesis in fibroblasts within a three-dimensional collagen gel. Exp. Cell Res. 178:493-503.
46. Mochitate, K., P. Pawelek, and F. Grinnell. 1991. Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down regulation of DNA and protein synthesis. Exp. Cell Res. 193:198-207.
47. Montesano, R., and L. Orci. 1988. Transforming growth factor β stimulates collagen-matrix contraction by fibroblasts: Implications for wound healing. Proc. Natl. Acad. Sci. USA. 85:4894-4897.
48. Nakagawa, S., P. Pawelek, and F. Grinnell. 1989a. Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness. Exp. Cell Res. 182:572-582.
49. Nakagawa, S., P. Pawelek, and F. Grinnell. 1989b. Long term culture of fibroblasts in contracted collagen gels: effects on cell growth and biosynthetic activity. J. Invest. Dermatol. 93:792-798.
50. Niewiarowski, S., and S. Goldstein. 1973. Interaction of cultured human fibroblasts with fibrin: modification by drugs and aging in vitro. J. Lab. Clin. Med. 82:605-610.
51. Nishiyama, T., M. Tsunenaga, Y. Nakayama, E. Adachi, and T. Hayashi. 1989. Growth rate of human fibroblasts is repressed by the culture within reconstituted collagen matrix but not by the culture on the matrix. Matrix 9:193-199.
52. Nishiyama, T., I. Horii, Y. Nakayama, T. Ozawa, and T. Hayashi. 1990. A distinct characteristic of the quiescent state of human dermal fibroblasts in contracted collagen gel as revealed by no response to epidermal growth factor alone, but a positive growth response to a combination of the factor and saikosaponin b. Matrix. 10:412-419.
53. Nishiyama, T., N. Akutsu, I. Horii, Y. Nakayama, T. Ozawa, and T. Hayashi. 1991. Response to growth factors of human dermal fibroblasts in a quiescent state owing to cell-matrix contact inhibition. Matrix. 11:71-75.
54. Nusgens, B., C. Merrill, C. Lapiere, and E. Bell. 1984. Collagen biosynthesis by cells in a tissue equivalent matrix in vitro. Collagen Relat. Res 4: 351-363.
55. Paye, M., B. V. Nusgens, and C. M. Lapiere. 1987. Modulation of cellular biosynthetic activity in the retracting collagen lattice. Eur. J. Cell Biol. 45:44-50.
56. Peacock, E. E. 1984. Wound Repair (3rd edition). W.B. Saunders Co., Philadelphia, PA.
57. Petroll, W. M., H. D. Cavanagh, P. Barry, P. Andrews, and J. V. Jester. 1993. Quantitative analysis of stress fiber orientation during corneal wound contraction. J. Cell Sci. 104:353-363.
58. Rockwell, W. B., I. K. Cohen, and H. P. Ehrlich. 1989. Keloids and hypertrophic scars: A comprehensive review. Plast. Reconstr. Surg. 84:827-837.
59. Ronnov-Jessen, L., and O. W. Petersen. 1993. Induction of α-smooth muscle actin by transforming growth factor-β1 in quiescent human breast gland fibroblasts. Lab. Invest. 68:696-707.
60. Rudolph, R., J. V. Berg, and H. P. Ehrlich. 1992. Wound contraction and scar contracture. In Wound Healing: Biochemical and Clinical Aspects. I. K. Cohen, R. F. Diegelmann, and W. J. Lindblad, editors. W.B. Saunders, Philadelphia, PA. 96:114.
61. Sappino, A. P., W. Schurch, and G. Gabbiani. 1990. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab. Invest. 63:144-161.
62. Sarber, R., B. Hull, C. Merrill, T. Soranno, and E. Bell. 1981. Regulation of proliferation of fibroblasts of low and high population doubling levels grown in collagen lattices. Mech. Ageing Dev. 17:107-117.
63. Schiro, J. A., B. M. C. Chan, W. T. Roswit, P. D. Kassner, A. P. Pentland, M. E. Hemler, A. Z. Eisen, and T. S. Kupper. 1991. Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 67:403-410.
64. Singer, I. I., D. W. Kawka, D. M. Kazazis, and R. A. F. Clark. 1984. The in vivo codistribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscopic studies of the fibronexus at the myofibroblast surface. J. Cell Biol. 98:2091-2106.
65. Skalli, O., and G. Gabbiani. 1988. The biology of the myofibroblast relationship to wound contraction and fibrocontractive disease. In The Molecular and Cellular Biology of Wound Repair. R. A. F. Clark and P. M. Henson, editors. Plenum Press, New York. 373-402.
66. Steinberg, B. M., K. Smith, M. Colozzo, and R. Pollack. 1980. Establishment and transformation diminish the ability of fibroblasts to contract a native collagen gel. J. Cell Biol. 87:304-308.
67. Stopak, D., and A. K. Harris. 1982. Connective tissue morphogenesis by fibroblast traction. I. Tissue culture observations. Dev. Biol. 90:383-398.
68. Tingstrom, A., C.-H. Heldin, and K. Rubin. 1992. Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1a and transforming growth factor-β1. J. Cell Sci. 102:315-322.
69. Tomasek, J. J., and C. J. Haaksma. 1991. Fibronectin filaments and actin microfilaments are organized into a fibronexus in Depuytren's diseased tissue. Anat. Rec. 230:175-182.
70. Tomasek, J. J., C. J. Haaksma, R. J. Eddy, and M. B. Vaughan. 1992. Fibroblast contraction occurs on release of tension in attached collagen lattices: dependency on an organized actin cytoskeleton and serum. Anat. Rec. 232:359-368.
71. Unemori, E. N., and Z. Werb. 1986. Reorganization of polymerized actin: A possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels. J. Cell Biol. 103:1021-1031.
72. Van Bockxmeer, F. M., C. E. Martin, and I. J. Constable. 1984. Effect of cyclic AMP on cellular contractility and DNA synthesis in chorioretinal fibroblasts maintained in collagen matrices. Exp. Cell Res. 155:413-421.
73. Watts, G. T., H. C. Grillo, and J. Gross. 1958. Studies in wound healing: II. The role of granulation tissue in contraction. Annals of Surgery 148(2): 153-160.
74. Welch, M. P., G. F. Odland, and R. A. F. Clark. 1990. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J. Cell Biol. 110:133-145.