Venous ischemia in skin flaps: Microcirculatory intravascular thrombosis

Plastic and Reconstructive Surgery

Volumn 93, Issue 2, 1994, Pages 366-374

  Hjortdal, Vibeke E ^a   Sinclair, Tom ^a   Kerrigan, Carolyn L ^a   Solymoss, Susan ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; FIBRINOGEN; VON WILLEBRAND FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; ISCHEMIA; LATISSIMUS DORSI FLAP; MICROCIRCULATION; MYOCUTANEOUS FLAP; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN FLAP SURVIVAL; SWINE; THROMBOCYTE ACTIVATION; THROMBOGENESIS; VEIN BLOOD FLOW;

ANIMAL; BLOOD FLOW VELOCITY; FEMALE; FIBRINOGEN; HEMATOCRIT; MICROCIRCULATION; MICROSCOPY, ELECTRON; PILOT PROJECTS; PLATELET COUNT; REPERFUSION INJURY; SKIN; SURGICAL FLAPS; SWINE; THROMBOPHLEBITIS; VEINS;

EID: 0027954668     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199402000-00023     Document Type: Article

References (25)

1. Strock, P. A., and Majno, G. Microvascular changes in acutely ischemic rat muscle. Surg. Gynecol. Obstet. 129: 1213, 1969.
2. Hartsock, L. A., Seaber, A. V., and Urbaniak, J. R. Intravascular thrombosis in skeletal muscle microcirculation after ischemia. Microsurgery 10: 161, 1989.
3. Wizman, P., and Kerrigan, C. L. Acute venous injury: Comparison o f secondary venous and arterial occlusion (Abstract). Reconstr. Microsurg. 7: 281, 1991.
4. Angel, M. F., Mellow, C. G., Knight, K. R., and O ’Brien, B. C. Secondary ischemia time in rodents: Contrasting complete pedicle interruption with venous obstruction. Plast. Reconstr. Surg. 85: 789, 1990.
5. Hergrueter, C. A., Handren, J., Kersh, R., and May, J. W., Jr. Human recombinant tissue type plasminogen activator and its effect on microvascular thrombosis in the rabbit. Plast. Reconstr. Surg. 81: 418, 1988.
6. Cooley, B. C., and Gould, J. S. Experimental models for evaluating antithrombotic therapies in replantation microsurgery. Microsurgery 8: 230, 1987.
7. Khouri, R. A., Cooley, B. C., Kenna, D. M., and Edstrom, L. E. Thrombosis of microvascular anastomoses in traumatized vessels: Fibrin versus platelets. Plast. Reconstr. Surg. 86: 110, 1990.
8. Hayden, R. E., McLear, P. W., Phillips, J. G., and Dawson, S. M. Thrombolysis with systemically administered i-PA in a new venous thrombosis model. Laryngoscope 99: 100, 1989.
9. Hayden, R. E., Phillips, J. G., and McLear, P. W. Leeches: Objective monitoring o f altered perfusion in congested flaps. Arch. Otolaryngol. Head Neck Surg. 114: 1395, 1988.
10. Clauss, A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 17: 237, 1957.
11. Wizman, P., Kerrigan, C. L., and Hjortdal, V. E. Acute skin flap injury: A comparison between global arterial and venous ischemia. Plast. Reconstr. Surg. (in press).
12. Hjortdal, V. E., Hansen, E. S., and Hauge, E. Myocutaneous flap ischemia: Flow dynamics following venous and arterial obstruction. Plast. Reconstr. Surg. 89: 1083, 1992.
13. Hjortdal, V. E., Hauge, E., and Hansen, E. S. Differential effects o f venous stasis and arterial insufficiency on tissue oxygenation in myocutaneous island flaps: An experimental study in pigs. Plast. Reconstr. Surg. 89: 521, 1992.
14. Dormandy, J. A. Clinical significance o f blood viscosity. Ann. R. Coll. Surg. (Engl.) 47: 211, 1970.
15. Vanhoutte, P. M., and Houston, D. S. Platelets, endothelium, and vasospasm. Circulation 72: 728, 1985.
16. Moneada, S., and Vane, J. R. Arachidonic acid metabolites and the interactions between platelets and bloodvessel walls. N. Engl. J. Med. 300: 1142, 1979.
17. Hjortdal, V. E., Solymoss, S., and Kerrigan, C. L. Alteration in Coagulation Status in Skin Flaps Designed Too Long for Their Inherent Vascular Supply. Paper presented at the Annual Meeting o f the American Society for Reconstructive Microsurgery, Orlando, Fla., 1991.
18. Johnson, P. C. Platelet-mediated thrombosis in microvascular surgery: New knowledge and strategies. Plast. Reconstr. Surg. 86: 359, 1990.
19. Hjortdal, V. E., Sinclair, T., Kerrigan, C. L., and Solymoss, S. Arterial ischemia in skin flaps: Microcirculatory intravascular thrombosis. Plast. Reconstr. Surg. 93: 375, 1994.
20. Morris, S. F. Pathogenesis and Treatment o f Ischemia- Induced Tissue Injury in the Latissimus Dorsi Myocutaneous Flap in Pigs. Thesis, Institute o f Medical Science, University o f Toronto, 1988.
21. Barker, J. H., Gu, J. M., Anderson, G. L., Acland, R. D., Derr, J. W., O’Shaughnessy, M., and White, S. The effects o f heparin and dietary fish oil on embolic events and the microcirculation downstream from a small artery repair. Plast. Reconstr. Surg. (in press).
22. Cange, S., Laberge, L. C., Rivard, G. E., and Garel, L. Streptokinase in the management o f limb arterial thrombosis following free-flap surgery. Plast. Reconstr. Surg. 79: 974, 1987.
23. Jacobs, G. R., Reinisch, J. F., and Puckett, C. L. Microvascular fibrinolysis after ischemia: Its relation to vascular patency and tissue survival. Plast. Reconstr. Surg. 68: 737, 1981.
24. Lipton, H. A., and Jupiter, J. B. Streptokinase salvage of a free-tissue transfer: Case report and review of the literature. Plast. Reconstr. Surg. 79: 977, 1987.
25. Schubert, W., Hunter, D. W., Guzman-Stein, G., Ahrenholz, D. H., Solem, L. D., Dressei, T. D., and Cunningham, B. L. Use o f streptokinase for the salvage of a free flap: Case report and review o f the use of thrombolytic therapy. Microsurgery 8: 117, 1987.