-
1
-
-
0025945012
-
Insulin resistance—mechanisms, syndromes, and implications
-
Moller DE, Flier JS 1991 Insulin resistance—mechanisms, syndromes, and implications. N Engl J Med 325:938-948
-
(1991)
N Engl J Med
, vol.325
, pp. 938-948
-
-
Moller, D.E.1
Flier, J.S.2
-
2
-
-
0025115342
-
Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects
-
Thies RS, Molina JM, Ciaraldi TP, Freidenberg GR, Olef-sky JM 1990 Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes 39:250-259
-
(1990)
Diabetes
, vol.39
, pp. 250-259
-
-
Thies, R.S.1
Molina, J.M.2
Ciaraldi, T.P.3
Freidenberg, G.R.4
Olef-Sky, J.M.5
-
3
-
-
0025746299
-
The insulin receptor: Signalling mechanism and contribution to the pathogenesis of insulin resistance
-
Haring HU 1991 The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance. Diabetologia 34:848-861
-
(1991)
Diabetologia
, vol.34
, pp. 848-861
-
-
Haring, H.U.1
-
4
-
-
0026656320
-
Lilly lecture: Molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene
-
Taylor SI 1992 Lilly lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene. Diabetes 41:1473-1490
-
(1992)
Diabetes
, vol.41
, pp. 1473-1490
-
-
Taylor, S.I.1
-
5
-
-
7144237021
-
Insulin regulation of protein phosphorylation
-
Cuatrecasas P, Jacobs S (eds, Springer-Verlag, Berlin/Heidelberg
-
Avruch J, Tornqvist HE, Gunsalus JR, Yurkow EJ, Kyriakis JM, Price DJ 1990 Insulin regulation of protein phosphorylation. In: Cuatrecasas P, Jacobs S (eds) Handbook of Experimental Pharmacology: Insulin. Springer-Verlag, Berlin/Heidelberg, vol 92:313-366
-
(1990)
Handbook of Experimental Pharmacology: Insulin
, vol.92
, pp. 313-366
-
-
Avruch, J.1
Tornqvist, H.E.2
Gunsalus, J.R.3
Yurkow, E.J.4
Kyriakis, J.M.5
Price, D.J.6
-
6
-
-
0025870736
-
Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells
-
Pillay TS, Whittaker J, Lammers R, Ullrich A, Siddle K 1991 Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells. FEBS Lett 288:206-211
-
(1991)
FEBS Lett
, vol.288
, pp. 206-211
-
-
Pillay, T.S.1
Whittaker, J.2
Lammers, R.3
Ullrich, A.4
Siddle, K.5
-
7
-
-
0027157576
-
Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamem-brane sites
-
Kohanski RA 1993 Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamem-brane sites. Biochemistry 32:5773-5780
-
(1993)
Biochemistry
, vol.32
, pp. 5773-5780
-
-
Kohanski, R.A.1
-
8
-
-
0023835955
-
Two systems in vitro that show insulin-stimulated serine kinase activity towards the insulin receptor
-
Smith DM, King MJ, Sale GJ 1988 Two systems in vitro that show insulin-stimulated serine kinase activity towards the insulin receptor. Biochem J 250:509-519
-
(1988)
Biochem J
, vol.250
, pp. 509-519
-
-
Smith, D.M.1
King, M.J.2
Sale, G.J.3
-
9
-
-
0025157186
-
Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase
-
Lewis RE, Wu GP, MacDonald RG, Czech MP 1990 Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase. J Biol Chem 265:947-954
-
(1990)
J Biol Chem
, vol.265
, pp. 947-954
-
-
Lewis, R.E.1
Wu, G.P.2
Macdonald, R.G.3
Czech, M.P.4
-
10
-
-
0021068997
-
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C
-
Jacobs S, Sahyoun NE, Saltiel AR, Cuatrecasas P 1983 Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci USA 80:6211-6213
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 6211-6213
-
-
Jacobs, S.1
Sahyoun, N.E.2
Saltiel, A.R.3
Cuatrecasas, P.4
-
11
-
-
0141434860
-
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyro-sine kinase activity
-
Bollag GE, Roth RA, Beaudoin J, Mochly-Rosen D, Koshland DEJ 1986 Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyro-sine kinase activity. Proc Natl Acad Sci USA 83:5822-5824
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 5822-5824
-
-
Bollag, G.E.1
Roth, R.A.2
Beaudoin, J.3
Mochly-Rosen, D.4
Koshland, D.5
-
12
-
-
0024439518
-
Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell
-
Koshio I, Akanuma Y, Kasuga M 1989 Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell. FEBS Lett 254:2224
-
(1989)
FEBS Lett
, vol.254
, pp. 2224
-
-
Koshio, I.1
Akanuma, Y.2
Kasuga, M.3
-
13
-
-
0025054967
-
Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C
-
Lewis RE, Cao L, Perregaux D, Czech MP 1990 Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C. Biochemistry 29:1807-1813
-
(1990)
Biochemistry
, vol.29
, pp. 1807-1813
-
-
Lewis, R.E.1
Cao, L.2
Perregaux, D.3
Czech, M.P.4
-
14
-
-
0027418067
-
Over-expression of protein kinase C iosenzymes α, β1, γ, and ϵ in cells overexpressing the insulin receptor
-
Chin JE, Dickens M, Tavare JM, Roth RA 1993 Over-expression of protein kinase C iosenzymes α, β1, γ, and ϵ in cells overexpressing the insulin receptor. J Biol Chem 268:6338-6347
-
(1993)
J Biol Chem
, vol.268
, pp. 6338-6347
-
-
Chin, J.E.1
Dickens, M.2
Tavare, J.M.3
Roth, R.A.4
-
15
-
-
0027408363
-
Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system
-
Ahn J, Donner DB, Rosen OM 1993 Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system. J Biol Chem 268:7571-7576
-
(1993)
J Biol Chem
, vol.268
, pp. 7571-7576
-
-
Ahn, J.1
Donner, D.B.2
Rosen, O.M.3
-
16
-
-
0024550280
-
Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphos-phate breakdown in liver from humans with and without type II diabetes
-
Thakker JK, DeMarchi R, MacDonald K, Caro JF 1989 Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphos-phate breakdown in liver from humans with and without type II diabetes. J Biol Chem 264:7169-7175
-
(1989)
J Biol Chem
, vol.264
, pp. 7169-7175
-
-
Thakker, J.K.1
Demarchi, R.2
Macdonald, K.3
Caro, J.F.4
-
17
-
-
0026015007
-
Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells
-
Muller HK, Kellerer M, Ermel B, Muhlhofer A, Obermaier-Kusser B, Vogt B, Haring HU 1991 Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells. Diabetes 40:1440-1448
-
(1991)
Diabetes
, vol.40
, pp. 1440-1448
-
-
Muller, H.K.1
Kellerer, M.2
Ermel, B.3
Muhlhofer, A.4
Obermaier-Kusser, B.5
Vogt, B.6
Haring, H.U.7
-
18
-
-
0026489335
-
Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
-
Inoguchi T, Battan R, Handler E, Sportsman R, Heath W, King GL 1992 Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89:11059-11063
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 11059-11063
-
-
Inoguchi, T.1
Battan, R.2
Handler, E.3
Sportsman, R.4
Heath, W.5
King, G.L.6
-
19
-
-
0023834876
-
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
-
Takayama S, White MF, Kahn CR 1988 Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem 263:3440-3447
-
(1988)
J Biol Chem
, vol.263
, pp. 3440-3447
-
-
Takayama, S.1
White, M.F.2
Kahn, C.R.3
-
20
-
-
0021733501
-
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells
-
Takayama S, White MF, Lauris V, Kahn CR 1984 Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci USA 81:7797-7801
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 7797-7801
-
-
Takayama, S.1
White, M.F.2
Lauris, V.3
Kahn, C.R.4
-
21
-
-
0025292249
-
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats
-
Karasik A, Rothenberg PL, Yamada K, White MF, Kahn CR 1990 Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. J Biol Chem 265:10226-10231
-
(1990)
J Biol Chem
, vol.265
, pp. 10226-10231
-
-
Karasik, A.1
Rothenberg, P.L.2
Yamada, K.3
White, M.F.4
Kahn, C.R.5
-
22
-
-
0027282090
-
Human insulin receptor mutated at Threonine 1336 functions normally in Chinese hamster ovary cells
-
Ahn J, Rosen OM, Donner DB 1993 Human insulin receptor mutated at Threonine 1336 functions normally in Chinese hamster ovary cells. J Biol Chem 268:16839-16844
-
(1993)
J Biol Chem
, vol.268
, pp. 16839-16844
-
-
Ahn, J.1
Rosen, O.M.2
Donner, D.B.3
-
23
-
-
0027241369
-
Phorbol esters induce insulin receptor phosphorylation in transfected fibroblasts without affecting tyrosine kinase activity
-
Coghlan MP, Siddle K 1993 Phorbol esters induce insulin receptor phosphorylation in transfected fibroblasts without affecting tyrosine kinase activity. Biochem Biophys Res Commun 193:371-377
-
(1993)
Biochem Biophys Res Commun
, vol.193
, pp. 371-377
-
-
Coghlan, M.P.1
Siddle, K.2
-
24
-
-
0027212268
-
The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains
-
Myers Jr MG, White MF 1993 The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes 42:643-650
-
(1993)
Diabetes
, vol.42
, pp. 643-650
-
-
Myers, M.G.1
White, M.F.2
-
25
-
-
0026438979
-
Regulation of insulin receptor sub-strate-1 in liver and muscle of animal models of insulin resistance
-
Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR 1992 Regulation of insulin receptor sub-strate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90:1839-1849
-
(1992)
J Clin Invest
, vol.90
, pp. 1839-1849
-
-
Saad, M.J.1
Araki, E.2
Miralpeix, M.3
Rothenberg, P.L.4
White, M.F.5
Kahn, C.R.6
-
26
-
-
0027190677
-
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice
-
Heydrick SJ, Jullien D, Gautier N, Tanti J-F, Giorgetti S, Van Obberghen E, Le Marchand-Brustel Y 1993 Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice. J Clin Invest 91:1358-1366
-
(1993)
J Clin Invest
, vol.91
, pp. 1358-1366
-
-
Heydrick, S.J.1
Jullien, D.2
Gautier, N.3
Tanti, J.-F.4
Giorgetti, S.5
Van Obberghen, E.6
Le Marchand-Brustel, Y.7
-
27
-
-
0026935518
-
Alterations in insulin receptor and substrate phosphorylation in hypertensive rats
-
Kahn CR, Saad MJ 1992 Alterations in insulin receptor and substrate phosphorylation in hypertensive rats. J Am Soc Nephrol 3:S69-S77
-
(1992)
J am Soc Nephrol
, vol.3
, pp. S69-S77
-
-
Kahn, C.R.1
Saad, M.J.2
-
28
-
-
0026660653
-
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation
-
Backer JM, Meyers Jr MG, Shoelson SE, Chin DJ, Sun Z-J, Miralpeix M, Hu P, flargolis B, Skolnik EY, Schlessinger J, White MF 1992 Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11:3469-3479
-
(1992)
EMBO J
, vol.11
, pp. 3469-3479
-
-
Backer, J.M.1
Meyers, M.G.2
Shoelson, S.E.3
Chin, D.J.4
Sun, Z.-J.5
Miralpeix, M.6
Hu, P.7
Flargolis, B.8
Skolnik, E.Y.9
Schlessinger, J.10
White, M.F.11
-
29
-
-
0026595373
-
Expression and function of IRS-1 in insulin signal transmission
-
Sun XJ, Miralpeix M, Myers MGJ, Glasheen EM, Backer JM, Kahn CR, White MF 1992 Expression and function of IRS-1 in insulin signal transmission. J Biol Chem 267:22662-22672
-
(1992)
J Biol Chem
, vol.267
, pp. 22662-22672
-
-
Sun, X.J.1
Miralpeix, M.2
Myers, M.3
Glasheen, E.M.4
Backer, J.M.5
Kahn, C.R.6
White, M.F.7
-
30
-
-
0027177288
-
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor l-stimulated maturation of Xenopus oocytes
-
Chuang L-M, Myers MGJ, Seidner GA, Birnbaum MJ, White MF, Kahn CR 1993 Insulin receptor substrate 1 mediates insulin and insulin-like growth factor l-stimulated maturation of Xenopus oocytes. Proc Natl Acad Sci USA 90:5172-5175
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 5172-5175
-
-
Chuang, L.-M.1
Myers, M.2
Seidner, G.A.3
Birnbaum, M.J.4
White, M.F.5
Kahn, C.R.6
-
31
-
-
0027158159
-
The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp
-
Kühne M, Pawson T, Lienhard GE, Feng G-S 1993 The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem 268:11479-11481
-
(1993)
J Biol Chem
, vol.268
, pp. 11479-11481
-
-
Kühne, M.1
Pawson, T.2
Lienhard, G.E.3
Feng, G.-S.4
-
32
-
-
0027311267
-
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2
-
Tobe K, Matuoka K, Tamemoto H, Ueki K, Kaburagi Y, Asai S, Noguchi T, Matsuda M, Tanaka S, Hattori S, Fukui Y, Akanuma Y, Yazaki Y, Takenawa T, Kadowaki T 1993 Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. J Biol Chem 268:11167-11171
-
(1993)
J Biol Chem
, vol.268
, pp. 11167-11171
-
-
Tobe, K.1
Matuoka, K.2
Tamemoto, H.3
Ueki, K.4
Kaburagi, Y.5
Asai, S.6
Noguchi, T.7
Matsuda, M.8
Tanaka, S.9
Hattori, S.10
Fukui, Y.11
Akanuma, Y.12
Yazaki, Y.13
Takenawa, T.14
Kadowaki, T.15
-
33
-
-
0026090241
-
Assessment of the in situ tyrosine kinase activity of mutant insulin receptors lacking tyrosine autophosphorylation sites 1162 and 1163
-
Yonezawa K, Roth RA 1991 Assessment of the in situ tyrosine kinase activity of mutant insulin receptors lacking tyrosine autophosphorylation sites 1162 and 1163. Mol Endocrinol 5:194-200
-
(1991)
Mol Endocrinol
, vol.5
, pp. 194-200
-
-
Yonezawa, K.1
Roth, R.A.2
-
34
-
-
0027450410
-
A tightly associated serine-threonine protein kinase regulates phosphoinosi-tide 3-kinase activity
-
Carpenter CL, Auger KR, Duckworth BC, Hou W-M, Schaffhausen B, Cantley LC 1993 A tightly associated serine-threonine protein kinase regulates phosphoinosi-tide 3-kinase activity. Mol Cell Biol 13:1657-1665
-
(1993)
Mol Cell Biol
, vol.13
, pp. 1657-1665
-
-
Carpenter, C.L.1
Auger, K.R.2
Duckworth, B.C.3
Hou, W.-M.4
Schaffhausen, B.5
Cantley, L.C.6
-
35
-
-
0026744181
-
Regulation of the expression of pp160, a putative insulin receptor signal protein, by insulin, dexamethasone, and 1-methyl-3-iso-butylxanthine in 3T3-L1 adipocytes
-
Rice KM, Lienhard GE, Garner CW 1992 Regulation of the expression of pp160, a putative insulin receptor signal protein, by insulin, dexamethasone, and 1-methyl-3-iso-butylxanthine in 3T3-L1 adipocytes. J Biol Chem 267:10163-10167
-
(1992)
J Biol Chem
, vol.267
, pp. 10163-10167
-
-
Rice, K.M.1
Lienhard, G.E.2
Garner, C.W.3
-
36
-
-
0025064397
-
Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase
-
Endemann G, Yonezawa K, Roth RA 1990 Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase. J Biol Chem 265:396-400
-
(1990)
J Biol Chem
, vol.265
, pp. 396-400
-
-
Endemann, G.1
Yonezawa, K.2
Roth, R.A.3
-
37
-
-
0027181695
-
Divergence of signaling pathways for insulin in PC-12 pheochromo-cytoma cells
-
Ohmichi M, Pang L, Ribon V, Saltiel AR 1993 Divergence of signaling pathways for insulin in PC-12 pheochromo-cytoma cells. Endocrinology 133:46-56
-
(1993)
Endocrinology
, vol.133
, pp. 46-56
-
-
Ohmichi, M.1
Pang, L.2
Ribon, V.3
Saltiel, A.R.4
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