Oxidative damage and mitochondrial decay in aging

Proceedings of the National Academy of Sciences of the United States of America

Volumn 91, Issue 23, 1994, Pages 10771-10778

  Shigenaga, Mark K ^a   Hagen, Tory M ^a   Ames, Bruce N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

acetyl L carnitine; bioenergetics; cardiolipin; mitochondrial DNA; neurodegeneration

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ASCORBIC ACID; CARDIOLIPIN; CARNITINE; CAROTENOID; CELL NUCLEUS DNA; CYTOCHROME C OXIDASE; CYTOCHROME P450; DEOXYGUANOSINE DERIVATIVE; EXCITATORY AMINO ACID; FATTY ACID; GLUTATHIONE; HISTONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LEVACECARNINE; LIPID; LIPOFUSCIN; MITOCHONDRIAL DNA; NITRIC OXIDE; OXIDIZING AGENT; OXIDOREDUCTASE; PHOSPHOLIPASE A2; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RECEPTOR; SUPEROXIDE; TOCOPHEROL; UNINDEXED DRUG;

AGING; BIOENERGY; CALORIC RESTRICTION; ELECTRON TRANSPORT; ENZYME ACTIVITY; FATTY ACID OXIDATION; HIBERNATION; HUMAN; LIPID PEROXIDATION; MEMBRANE FLUIDITY; METABOLIC RATE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MITOGENESIS; MUTATION; NONHUMAN; OXIDATIVE STRESS; PHYLOGENY; PRIORITY JOURNAL; REVIEW;

AGING; ANIMAL; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ENERGY METABOLISM; HUMAN; HYDROGEN PEROXIDE; IMMUNE SYSTEM; INTRACELLULAR MEMBRANES; LIPIDS; LONGEVITY; MITOCHONDRIA; MUTATION; NEURONS; OXIDATION-REDUCTION; PHYLOGENY; PROTEINS; SUPEROXIDES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027949202     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.91.23.10771     Document Type: Review

References (133)