Bromobenzofuran-Based Non-peptide Antagonists of Angiotensin II: GR138950, a Potent Antihypertensive Agent with High Oral Bioavailability

Journal of Medicinal Chemistry

Volumn 37, Issue 19, 1994, Pages 3108-3120

  Judd, Duncan B ^a   Dowle, Michael D ^a   Middlemiss, David ^a   Scopes, David I C ^a   Ross, Barry C ^a   Jack, Torquil I ^a   Pass, Martin ^a   Tranquillini, Elvira ^a   Hobson, Julie E ^a   Panchal, Terry A ^a   Stuart, Peter G ^a   Paton, John M S ^a   Hubbard, Tania ^a   Hilditch, Anthony ^a,b   Drew, Geoffrey M ^a,b   Robertson, Mark J ^a,a,b   Clark, Kenneth L ^a,a,b   Travers, Alison ^a,b   Hunt, Anthony A E ^a,a,b   Polley, Joanne ^a,b   Eddershaw, Peter J ^a,c   Bayliss, Martin K ^a,c   Manchee, Garry R ^a,c   Donnelly, Mary D ^a,a,c   Walker, David G ^a,a,c   Richards, Stephen A ^a,a,d   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b Departments of Pharmacology 2 ^*  (United Kingdom)

^c Departments of Drug Metabolism ^*  (United Kingdom)

^d Departments of Spectroscopy ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II ANTAGONIST; ANTIHYPERTENSIVE AGENT; BENZOFURAN DERIVATIVE; SAPRISARTAN; ZOLASARTAN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA CLEARANCE; PLASMA HALF LIFE; RABBIT; RAT; RENOVASCULAR HYPERTENSION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMAL; ANTIHYPERTENSIVE AGENTS; BENZOFURANS; BIOLOGICAL AVAILABILITY; DISEASE MODELS, ANIMAL; DOGS; HYPERTENSION; IN VITRO; KINETICS; MOLECULAR SEQUENCE DATA; RABBITS; RATS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027946227     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00045a016     Document Type: Article

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