Metabolic disposition of imipramine in oriental subjects: Relation to metoprolol α-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes

Journal of Pharmacology and Experimental Therapeutics

Volumn 271, Issue 2, 1994, Pages 860-867

  Koyama, E ^a   Sohn, D R ^a   Shin, S G ^a   Chiba, K ^a   Shin, J G ^a   Kim, Y H ^a   Echizen, H ^a   Ishizaki, T ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYDESIPRAMINE; 2 HYDROXYIMIPRAMINE; 4' HYDROXYMEPHENYTOIN; ALPHA HYDROXYMETOPROLOL; CYTOCHROME P450; DEBRISOQUINE; DESIPRAMINE; IMIPRAMINE; MEPHENYTOIN; METOPROLOL; N DEMETHYLASE; PHENYTOIN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; JAPAN; KOREA; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL;

ADULT; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; FEMALE; HUMAN; HYDROXYLATION; IMIPRAMINE; ISOENZYMES; MALE; MEPHENYTOIN; METOPROLOL; MIXED FUNCTION OXYGENASES; MONGOLOID RACE; PHENOTYPE; SUPPORT, NON-U.S. GOV'T;

EID: 0027945112     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)