Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

Journal of the American College of Cardiology

Volumn 24, Issue 7, 1994, Pages 1611-1617

  Gilligan, David M ^a   Sack, Michael N ^a   Guetta, Victor ^a   Casino, Philip R ^a   Quyyumi, Arshed A ^a   Rader, Daniel J ^a   Panza, Julio A ^a   Cannon III, Richard O ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; NITROPRUSSIDE SODIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; FOREARM BLOOD FLOW; HUMAN; HYPERCHOLESTEROLEMIA; INTRAARTERIAL DRUG ADMINISTRATION; MALE; OXIDATION; PRIORITY JOURNAL; VASODILATATION;

ACETYLCHOLINE; ADOLESCENT; ADULT; AGED; ANTIOXIDANTS; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; NITROPRUSSIDE; OXIDATION-REDUCTION; VASODILATION; VITAMINS;

EID: 0027943213     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0735-1097(94)90164-3     Document Type: Article

References (41)

1. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
2. Control of coronary vascular tone by nitric oxide
3. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
4. Endothelial function in human coronary arteries in vivo: focus on hypercholesterolemia
5. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis
6. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans
7. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease
8. Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolemia
9. The role of nitric oxide in the endothelium-dependent vasodilation of hypercholesterolemic patients
10. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
11. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta
12. Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries
13. Antioxidant vitamins and coronary heart disease
14. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension
15. The distribution and chemical composition of ultracentrif gally seperated lipoproteins in human serum
16. Measurement of protein using bicinchonic acid
17. Continuous monitoring of in vitro oxidation of human low density lipoprotein
18. A fluorometric micromethod for serum vitamins A and E
19. Repeated measures
20. Auto-oxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes
21. α-Tocopherol consumption during low-density-lipoprotein oxidation
22. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and α-tocopherol content
23. Antioxidants in relation to lipid peroxidation
24. Low-dose α-tocopherol improves and high-dose α-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits
25. Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking
26. Effect of combined supplementation with α-tocopherol, ascorbate, and beta-carotene on low-density lipoprotien oxidation
27. The effect of dietary supplementation with alphatocopherol on the oxidative modification of low density lipoprotein
28. Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking
29. Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy
30. Correction of endothelial dysfunction in the coronary microcirculation of hypercholesterolemic patients by L-arginine
31. Effects of L-arginine into the left anterior descending artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries
32. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans
33. Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients
34. Coronary endothelial responses are improved with aggressive lipid lowering therapy in patients with coronary atherosclerosis [abstract]
35. Cholesterol lowering therapy improves endothelial function in patients with coronary atherosclerosis [abstract]
36. Cholesterol lowering therapy restores small artery endothelial function in hypercholesterolemic subjects [abstract]
37. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomation in patients with hypercholestorolemia
38. Hypercholesterolemia increases endothelial superoxide anion production
39. Superoxide anion is an endothelium-derived contracting factor
40. Diet-induced atherosclerosis mereases the reiease of nitrogen oxides from rabbit aorta