Intragenomic heterogeneity of DNA damage formation and repair: A review of cellular responses to covalent drug DNA interaction

Critical Reviews in Toxicology

Volumn 24, Issue 4, 1994, Pages 281-322

  Wassermann, Karsten ^a,b  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b NONE   (Denmark)

Author keywords

Cell cycle; DNA fragmentation; Gene specific repair; Mammalian cells; Morpholinyl anthracyclines; N alkylpurines; Nitrogen mustard; Transcription

Indexed keywords

3' (3 CYANOMORPHOLINO) 3' DEAMINODOXORUBICIN; 3' DEAMINO 3' MORPHOLINODOXORUBICIN; ANTHRACYCLINE DERIVATIVE; CHLORMETHINE; DNA FRAGMENT; DOXORUBICIN;

COVALENT BOND; DNA DAMAGE; DNA REPAIR; DRUG DNA INTERACTION; GENOME; HUMAN; HUMAN CELL; REVIEW; RNA SYNTHESIS;

ALKYLATING AGENTS; ANIMAL; ANTIBIOTICS, ANTHRACYCLINE; BACTERIAL PROTEINS; DNA; DNA DAMAGE; DNA REPAIR; DRUG INTERACTIONS; GENOME; HUMAN; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS;

EID: 0027942531     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.3109/10408449409017921     Document Type: Article

References (215)

1. Molecular electrostatic potential of the nucleic acids
2. Heterogeneous DNA damage and repair in the mammalian genome
3. Formation of blocking lesions at identical DNA sequences by the nitrosourea and platinum classes of anticancer drugs
4. Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase
5. Transcription-terminating lesions induced by bifunctional alkylating agents in vitro
6. In vitro transcription analysis of DNA alkylation by nitrogen mustard
7. Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements
8. Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin
9. Cancer-prone hereditary diseases with DNA processing abnormalities
10. DNA repair and aging in basal cell carcinoma: a molecular epidemiology study
11. Do chemo- and radiotherapy affect the DNA repair ability of lymphocytes?
12. DNA repair in lymphocytes from patients with secondary leukemia as measured by strand rejoining and unscheduled DNA synthesis
13. Cellular resistance to cancer chemotherapy
14. Genetical implications of the structure of deoxyribonucleic acid
15. Subunit structure of chromatin
16. Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromation
17. Size-dependence of a stable higher-order structure of chromatin
18. The structure of histone-depleted metaphase chromosomes
19. Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster
20. Chromatin
21. Topoisomerase II is a structural component of mitotic chromosome scaffolds
22. DNA topoisomerase poisons as antitumor drugs
23. Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA
24. Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription
25. Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome
26. Sites of topoisomerase I action on X. laevis ribosomal chromatin: transcriptionally active rDNA has an approximately 200 bp repeating structure
27. Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies
28. The nucleoskeleton and the topology of transcription
29. Analysis of the attachment of replicating DNA to a nuclear matrix in mammalian interphase nuclei
30. Sequence-specific DNA-binding proteins are components of a nuclear matrix-attachment site
31. Nuclear structure and the three-dimensional organization of DNA
32. Actively transcribed genes are associated with the nuclear matrix
33. The organisation of chromatin loops: characterization of a scaffold attachment site
34. Nuclease hypersensitive sites in chromatin
35. Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly
36. Nucleosome core displacement in vitro via a metastable transcription factor-nucleosome complex
37. Transcriptionally active chromatin
38. Sequence and organization of the human mitochondrial genome
39. Transcription of the mammalian mitochondrial genome
40. Intensely potent morpholinyl anthracyclines
41. Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog
42. 3′-(3-Cyano-4-morpholinyl)-3′-deaminoadriamycin: a new anthracycline with intense potency
43. Comparative cytotoxicities of various morpholinyl anthracyclines
44. Effects of 3′-deamino-3′-(3-cyano-4-morpholinyl)doxorubicinand doxorubicin on the survival, DNA integrity, and nucleolar morphology of human leukemia cells in vitro
45. DNA cross-linking and cytotoxicity of the alkylating cyanomorpholino derivative of doxorubicin in multidrug-resistant cells
46. Novel DNA groove binding alkylators: design, synthesis, and biological evaluation
47. Selective DNA interaction of the novel distamycin derivative FCE 24517
48. Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumour cells
49. DNA crosslinking by3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin in HT-29 human colon carcinoma cells in vitro
50. Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and resistant P388 cells
51. Cellular pharmacology of 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin and structural analogues in human colon carcinoma HT-29 cells in vitro
52. Uptake and binding of 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin and 3′-(4-morpholinyl)-3′-deaminoadriamycin in L5178Y lymphoblasts in vitro
53. Molecular mechanisms of binding and single-strand scission of deoxyribonucleic acid by the antitumor antibiotic saframycins A and C
54. Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumor antibiotics: morpholinyldaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin
55. Effects of 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin and structural analogues on DNA in HT-29 human colon carcinoma cells
56. Characterization of the DNA-DNA cross-linking activity of 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin
57. Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerase I and II
58. Morpholinyl anthracyclines
59. Association of DNA crosslinking with potentiation of the morpholino derivative of doxorubicin by human liver microsomes
60. Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes
61. The alkylating agents
62. Cyanoethylation of DNA in vivo by 3-(methylnitro-samino)propionitrile and Areca-derived carcinogen
63. The generation of potentially toxic, reactive iminium ions from the oxidative metabolism of xenobiotic N-alkyl compounds
64. Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of 1-benzylpyrrolidine
65. Metabolism of the nigrostriatal toxin l-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine by liver homogenate fractions
66. The DNA sequence specificity of cyanomorpholinoadriamycin
67. Transcriptional analysis of multisites drug-DNA dissociation kinetics: delayed termination of transcription by actinomycin D
68. Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards
69. DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards
70. DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells
71. Interstrand crosslinking of DNA by nitrogen mustard
72. Interstrand cross-linking of DNA by difunctional alkylating agents
73. Intrastrand bifunctional alkylation of DNA in mammalian cells treated with mustard gas
74. Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards
75. Characterization of DNA-protein cross-links formed by treatment of L1210 cells and nuclei withbis (2-chloroethyl)methylamine (nitrogen mustard)
76. Effect of ionic strength and cationic DNA affinity binders on the DNA sequence alkylation of guanine N7-positions by nitrogen mustards
77. DNA sequence selectivity of guanine-N7 alkylation by three antitumor chlorethylating agents
78. Use of an indicator sequence of human DNA to study DNA damage by methylbis(2-chloroethyl)amine
79. Gene distribution and nucleotide sequence organization in the human genome
80. GC-rich regions in genomes as targets for DNA alkylation
81. Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5′ region of the CHOdhfr gene
82. Variation among human 28S ribosomal RNA genes
83. Human 28S ribosomal RNA sequence heterogeneity
84. Selective repair of methylated purines in regions of chromatin DNA
85. Non-random alkylation of DNA sequences induced in vivo by chemical mutagens
86. Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation
87. Assessment of preferential cleavage of an actively transcribed retroviral hybrid gene in murine cells by deoxyribo-nuclease I, bleomycin, neocarzinostatin, or ionizing radiation
88. Two expressed human genes sustain slightly more DNA damage after alkylating agent treatment than an inactive gene
89. Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells
90. Overexpression of metallothionein in Chinese hamster ovary cells and its effect on nitrogen mustard-induced cytotoxicity: role of gene-specific damage and repair
91. Gene-specific DNA repair of interstrand cross-links induced by chemotherapeutic agents can be preferential
92. Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin
93. Differential introduction and repair of psoralen photoadducts to DNA in specific human genes
94. Gene-specific DNA interstrand crosslinks produced by nitrogen mustard in the human tumor cell line colo320HSR
95. Alkylation of individual genes in rat liver by the carcinogen N-nitrosodimethylamine
96. Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene
97. Preferential DNA repair of alkali-labile sites within the active insulin gene
98. Transcriptionally active and inactive genes are similarly modified by chemical carcinogens or X-ray in normal fibroblasts
99. Enhanced antitumor properties of 3′-(4-morpholinyl) and 3′-(4-methoxy-l-piperidinyl) derivatives of 3′-deaminodaunorubicin
100. N-alkylation of anthracyclines
101. Pharmacological studies of 3′-(4-morpholinyl)-3′-deaminodaunorubicin in human colon carcinoma cells in vitro
102. Cellular pharmacology of 3′-(4-morpholinyl) and 3′-(4-methoxy-l-piperidinyl) derivatives of 3′-deaminodaunorubicin in human colon carcinoma cells in vitro
103. Effects of actinomycin D on the association of newly formed ribonucleoproteins with the cistrons of ribosomal RNA in triturus oocytes
104. Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry
105. Selective inhibition of human ribosomal gene transcription by the morpholinyl anthracyclines cyanomoipholinyl- and morpholinyldoxorubicin
106. Ongoing activity of RNA polymerase II confers preferential repair of nitrogen mustard-induced N-alkylpurines in the hamster dihydrofolate reductase gene
107. Repair of ribosomal RNA genes in hamster cells after UV irradiation, or treatment with cisplatin or alkylating agents
108. Differential inhibition of the DNA binding of transcription factors NFxB and OTF-1 by nitrogen mustard and quinacrine mustard: transcriptional implications
109. Gene and transcription mapping by radiation effects
110. Transcription preferentially inhibits nucleotide excision repair of the template DNA strand in vitro
111. The effects of covalent additions of psoralen on transcription by E. coli RNA polymerase
112. Interaction of Escherichia coli RNA polymerase with DNA in an elongation complex arrested at a specific psoralen crosslink site
113. Mechanism of aflatoxin B1 inhibition of rat hepatic nuclear RNA synthesis
114. Topoisomerase II inhibition by antitumor intercalators and dimethyl-epipodophyllotoxins
115. Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG)
116. Protein-associated DNA breaks in cells treated with adriamycin or ellipticine
117. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase n
118. Transcription generates positively and negatively supercoiled domains in the template
119. A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin
120. Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes
121. DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1, 3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas
122. Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard
123. Nitrogen mustard induces apoptosis in the Colo320HSR cell line containing an amplified c-myc oncogene
124. Induction and disappearance of DNA single-strand breaks in human B and T lymphocytes after exposure to ethyl-nitrosourea
125. Paradoxical increase in DNA cross-linking in a human ovarian carcinoma cell line resistant to cyano-morpholinio doxorubicin
126. N-(5, 5-Diacetoxypentyl)doxorubicin: a novel anthracycline producing DNA interstrand cross-linking and rapid endonucleolytic cleavage in human leukemia cells
127. Correlation between anthracycline structure and human DNA ligase inhibition
128. Post-repair DNA damage in X-irradiated cultured human tumour cells
129. Induction of apoptosis in Chinese hamster ovary cells by α-amanitin
130. Different drugs arrest cells at a number of distinct stages in G2
131. The molecular basis of drug-induced G2 arrest in mammalian cells
132. G2 block induced by DNA crosslinking agents and its possible consequences
133. Checkpoints: control that ensures the order of cell cycle events
134. Mechanism of cis-diaminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and double-strand breaks
135. Cell cycle arrest and DNA damage after melphalan treatment of the human myeloma cell line RPMI 8226
136. Relationships between cdc2 kinase, DNA cross-linking, and cell cycle perturbations induced by nitrogen mustard
137. Participation of p53 protein in the cellular response to DNA damage
138. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
139. Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines
140. In vitro repair of single-strand breaks in irradiated DNA by polynucleotide ligase
141. Classification of chemical agents as to their ability to induce long- or short-patch DNA repair in human cells
142. Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5′ and the 6th phospho-diester bond 3′ to the photodimer
143. Bleomycin-induced DNA repair synthesis in permeable human fibroblasts: mediation of long-patch and short-patch repair by distinct DNA polymerases
144. Genes and proteins of saccharomyces cerevisiae that function in postreplication repair
145. Expression of DNA repair genes in mammalian cells
146. Deficient repair of chemical ad-ducts in α DNA of monkey cells
147. Preferential repair of nuclear matrix associated DNA in xeroderma pigmentosum complementation group
148. Nuclear matrix associated DNA is preferentially repaired in normal human fibroblasts, exposed to a low dose of ultraviolet light but not in Cockayne's syndrome fibroblasts
149. Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xerodermia pigmentosum
150. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
151. Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos
152. Processing of psoralen adducts in an active human gene: repair and replication of DNA containing monoadducts and interstrand cross-links
153. Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes
154. Measurement of the pyrimidine dimer content of DNA in permeabilized bacterial or mammalian cells with endonuclease V of bacteriophage T4
155. Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene
156. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
157. Preferential DNA repair of an active gene in human cells
158. Preferential repair of DNA damage on the transcribed strand of the human metallothionein genes requires RNA polymerase II
159. Deoxyribonucleic acid excision repair in chromatin after ultraviolet irradiation of human fibroblasts in culture
160. Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting
161. Studies on the stability of trialkyl phosphates and di-(2′-deoxythymidine) phosphotriesters in alkaline and neutral solution. A model study for hydrolysis of phosphotriesters in DNA and on the influence of a β-hydroxyethyl ester group
162. Mechanism of DNA strand breakage by piperidine at sites of N7-alkylguanines
163. Differences in the in vivo alkylation and cross-linking of nitrogen mustard-sensitive and -resistant lines of Lettré-Ehrlich ascites tumors
164. A comparison of the effects of alkylation on the DNA of sensitive and resistant Lettré-Ehrlich cells following in vivo exposure to nitrogen mustard
165. Reaction of apurinc acid with aldehyde reagents
166. Reaction of apurinic/apyrimidinic sites with [14C]methoxyamine. A method for the quantitative assay of AP sites in DNA
167. Induction of fos RNA by DNA-damaging agents
168. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand
169. Gene- and strand-specific repair in vitro: partial purification of a transcription-repair coupling factor
170. Animal DNA-dependent RNA polymerases. Mechanism of the inhibitors of RNA polymerases B by amatoxins
171. Formation of a single phosphodiester bond by RNA polymerase B from calf thymus is not inhibited by α-amanitin
172. Localized torsional tension in the DNA of human cells
173. Inhibition of transcription and strand-specific DNA repair by α-amanitin in Chinese hamster ovary cells
174. DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor
175. Escherichia coli mfd mutant deficient in “mutation frequency decline” lacks strand-specific repair: in vitro complementation with purified coupling factor
176. Molecular mechanism of transcription-repair coupling
177. Coordinate expression of amplified metallothionein I and II genes in cadmium-resistant Chinese hamster cells
178. Nuclease sensitivity of α-fetoprotein, metallothionein-1, and immunoglobulin gene sequences in mouse during development, Dev
179. Transcription-independent repair of nitrogen mustard-induced N-alkylpurines in the c-myc gene in Burkitt's lymphoma CA46 cells
180. Oncogene activation by chromosome translocation in human malignancy
181. Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma
182. Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells
183. Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives
184. DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice
185. Transcription affects the rate but not the extent of repair of cyclobutane pyrimidine dimers in the human adenosine deaminase gene
186. Identification of a nuclear matrix-associated region of the c-myc protooncogene and its recognition by a nuclear protein in the human leukemia HL-60 cell line
187. Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma
188. Differential introduction of DNA damage and repair in mammalian genes transcribed by RNA polymerases I and II
189. Differential repair and replication of damaged DNA in ribosomal RNA genes in different CHO cell lines
190. The unexpected structures of eukaryotic genomes
191. Heterogeneous repair of methyl-nitrosourea-induced alkali-labile sites in different DNA sequences
192. Effects of N-methyl-N-nitrosourea on transcriptionally active and inactive nucleosomes: macromolecular damage and DNA repair
193. Use of fluorescently tagged DNA and a automated DNA sequencer for the comparison of the sequence selectivity of SN1 and SN2 alkylating agents
194. Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells
195. Purification and properties of mitochondrial uracil-DNA glycosylase from rat liver
196. Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA
197. Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin
198. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells
199. Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cells
200. An altered apurinic DNA endonuclease activity in group A and group D xeroderma pigmentosum fibroblasts
201. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
202. Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines
203. DNA topoisomerases: enzymes that control DNA conformation
204. 5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity
205. Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells
206. Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells
207. Novobiocin enhances alkylating agents cytotoxicity and DNA interstrand crosslinks in a murine model
208. A phase I clinical trial of novobiocin, a modulator of alkylating agent cytotoxicity
209. Radiotherapy- and chemotherapy-induced myelodysplasia and acute myeloid leukemia. A review
210. DNA topoisomerases
211. Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells
212. Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in die HPRT gene of diploid human fibroblasts
213. Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylamino-fluorene and dimenthyl sulfate in vitro