Heparan sulfate fibroblast growth factor receptor complex: Structure‐function relationships

Molecular Reproduction and Development

Volumn 39, Issue 1, 1994, Pages 69-82

  McKeehan, Wallace L ^a   Kan, Mikio ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Cancer; Cytokines; Signal transduction

Indexed keywords

CYTOKINE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARAN SULFATE; MEMBRANE ENZYME; PHOSPHOLIPASE; PROTEIN TYROSINE KINASE;

AMINO TERMINAL SEQUENCE; BINDING SITE; CANCER GENETICS; CONFERENCE PAPER; DIMERIZATION; LIGAND BINDING; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR BINDING; RNA SPLICING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; CONSERVED SEQUENCE; HEPARITIN SULFATE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASE C; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, FIBROBLAST GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027940213     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.1080390112     Document Type: Article

References (23)

1. Receptor‐ and heparin‐binding domains of basic fibroblast growth factor
2. Three‐dimensional structure of human basic fibroblast growth factor
3. Expression of human tyrosine kinase‐negative epidermal growth factor receptor amplifies signaling through endogenous murine epidermal growth factor receptor
4. Fibroblast growth factor receptors from liver vary in three structural domains
5. Substitution of a putative half‐cystine residue in heparin‐binding fibroblast growth factor receptors. Loss of activity in both two and three loop isoforms
6. Identification of tyrosines 154 and 307 in the extracellular domain and 653 and 766 in the intracellular domain as phoshorylation sites in the heparin‐binding fibroblast growth factor receptor tyrosine kinase (fig)
7. Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction
8. The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain
9. Fibronectin, not laminin, mediates heparin‐dependent heparin‐binding growth factor type 1 binding to substrata and stimulation of endothelial cell growth
10. An essential heparin‐binding domain in the fibroblast growth factor receptor kinase
11. A tyrosine‐phosphorylated carboxyl‐terminal peptide of the fibroblast growth factor receptor flg is a binding site for the SH2 domain of phospholipase
12. Requirement of heparan sulfate for bFGF‐mediated fibroblast growth and myoblast differentiation
13. Direct linkage of heparin binding (fibroblast) growth factor type one to a fragment of its receptor extracellular domain after receptor‐dependent internalization
14. 16‐kilodalton heparin binding (fibroblast) growth factor type one appears in a stable 40‐kilodalton complex after receptor‐dependent internalization
15. Control of FGF receptor kinase signal transduction by heterodimerization
16. Signal transduction by receptors with tyrosine kinase activity
17. Expression and immunochemical analysis of rat prostate and human heparin‐binding fibroblast growth factor receptor flg isoforms
18. Expression and transforming activity of a variant of the heparin‐binding fibroblast growth factor receptor flg gene resulting from splicing of the alpha exon at an alternate 3′‐acceptor site
19. Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)‐FGF receptor genes in prostate epithelial cells accompanies stromal independence and malignancy
20. Exon skipping causes alteration of the COOH‐terminus and deletion of the phospholipase Cγ1 interaction site in the FGF receptor 2 kinase in normal epithelial cells
21. Cell surface, heparin‐like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor