Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.

British Journal of Clinical Pharmacology

Volumn 38, Issue 2, 1994, Pages 147-150

  Van der Ven, AJ ^a   Mantel, MA ^a   Vree, TB ^a   Koopmans, PP ^a   Van der Meer, JW ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; HYDROXYLAMINE; SULFAMETHOXAZOLE; SULFAMETHOXAZOLE HYDROXYLAMINE; UNCLASSIFIED DRUG;

ACETYLATOR PHENOTYPE; ADULT; ARTICLE; CLINICAL TRIAL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; URINARY EXCRETION;

ACETYLATION; ADMINISTRATION, ORAL; ADULT; CAUCASOID RACE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HALF-LIFE; HUMAN; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGE; PHENOTYPE; SULFAMETHOXAZOLE;

EID: 0027939552     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1994.tb04339.x     Document Type: Article

References (16)

1. Adverse reactions to trimethoprim‐sulfamethoxazole in patients with the acquired immunodeficiency syndrome
2. Synthesis and in vitro toxicity of hydroxylamine metabolites of sulfonamides
3. Diagnosis of sulfonamide hypersensitivity reactions by in vitro‘rechallenge’ with hydroxylamine metabolites
4. In vitro evaluation of a toxic metabolite of sulfadiazine
5. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity
6. Sulfamethoxazole is metabolized to the hydroxylamine in humans
7. Adverse reactions to cotrimoxazole in HIV infection
8. Systemic glutathione deficiency in symptom‐free HIV‐infected individuals
9. The hydroxylamine of sulfamethoxazole is associated with toxicity in patients with AIDS
10. The putative mechanism of side‐effects of sulfonamides in HIV seropositive patients and an option for treatment modification
11. Clinical pharmacokinetics of sulfonamides and their metabolites. An encyclopedia
12. Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions
13. Determination of the acetylator phenotype and pharmacokinetics of some sulfonamides in man
14. MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring
15. Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione
16. Pharmacokinetics of sulfamethoxazole in man: Effects of urinary pH and urine flow on metabolism and renal excretion of sulfamethoxazole and its metabolite N4‐acetylsulfamethoxazole