Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat

Life Sciences

Volumn 55, Issue 16, 1994, Pages 1285-1291

  Fujita, Katsuya ^a   Matsumura, Yasou ^a   Kita, Satomi ^a   Hisaki, Kazuhiro ^a   Takaoka, Masanori ^a   Morimoto, Shiro ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

big endothelin 1; endothelin 1; kidney; phosphoramidon; vasoconstriction

Indexed keywords

BIG ENDOTHELIN 1; ENDOTHELIN 1; ENDOTHELIN CONVERTING ENZYME; PHOSPHORAMIDON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; ISOLATED KIDNEY; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; KIDNEY VASCULAR RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; RAT;

ANIMAL; BLOOD PRESSURE; COMPARATIVE STUDY; ENDOTHELINS; GLYCOPEPTIDES; IN VITRO; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION; SUPPORT, NON-U.S. GOV'T; VASCULAR RESISTANCE; VASOCONSTRICTION;

ANIMALIA;

EID: 0027938703     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(94)90067-1     Document Type: Article

References (21)

1. Y. MATSUMURA, M. TAKAOKA, K. HISAKI and S. MORIMOTO, Endothelin converting enzyme and its inhibitors: Pathophysiological significance. In Endothelin: Role in health and disease, edited by A. Gulati, in press, Switzerland: Harwood Academic Publishers gmbh.
2. Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.